Short-term stress significantly decreases morphine analgesia in trigeminal but not in spinal innervated areas in rats

Bagüés, Ana; Girón, Rocı́o; Abalo, Raquel; Goicoechea, Carlos; Martín‐Fontelles, Ma Isabel; Sánchez, Esteban Fernández

doi:10.1016/j.bbr.2022.114046

Cited by 3 publications

(7 citation statements)

References 58 publications

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“…There have been consistent results identifying the presence of anxiety-like behavior associated with the model in mirror-chamber assessments as well [115,117,120]. Among more commonly investigated anxiety-like behaviors, there are mixed results in measures of EPM, with prominence leading towards anxiety-like behaviors not being consistently found within the model (significance identified: [114,115]; significance not identified: [111,113,116,117,120]). In measures of OFT, results have repeatedly implied that the model does not produce anxiety-like changes in locomotion [116,118,119].…”

Section: Subchronic Swim Evaluationmentioning

confidence: 67%

“…Significant: [111-117] [118,119] Antidepressants: [113,117,120] Narcotic analgesic: [111] NMDA receptor antagonist: [113] NOS antagonist: [118,119] Organics: [115,[117][118][119] Non-significant: [118,119] --…”

Section: Subchronic Swim Stressmentioning

confidence: 99%

“…The only study highlighted in review that reported an absence of depression-like behaviors may be a result of a stark difference in experimental design, wherein the cumulative impact of inflammatory pain and swim stress was investigated [121]. However, alterations in motivational elements were also identified in review, such as increased escape behavior [113] or changes in general locomotion [111,118,119].…”

Section: Subchronic Swim Evaluationmentioning

confidence: 99%

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The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

Argenbright,

Bertlesman,

Russell

et al. 2024

Biomedicines

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Fibromyalgia is a chronic, widespread pain disorder that is strongly represented across the affective and cognitive dimensions of pain, given that the underlying pathophysiology of the disorder is yet to be identified. These affective and cognitive deficits are crucial to understanding and treating the fibromyalgia pain experience as a whole but replicating this multidimensionality on a preclinical level is challenging. To understand the underlying mechanisms, animal models are used. In this scoping review, we evaluate the current primary animal models of fibromyalgia regarding their translational relevance within the affective and cognitive pain realms, as well as summarize treatments that have been identified preclinically for attenuating these deficits.

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Section: Subchronic Swim Evaluationmentioning

confidence: 67%

Section: Subchronic Swim Stressmentioning

confidence: 99%

Section: Subchronic Swim Evaluationmentioning

confidence: 99%

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The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

Argenbright,

Bertlesman,

Russell

et al. 2024

Biomedicines

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“…It has a strong analgesic effect and is mainly used for severe pain such as advanced stage of cancer pain. At the same time, the abuse of opioid analgesics in the United States has reached the point of affecting life expectancy, and new analgesics are urgently needed in the market 34–37 . As far as costs are concerned, the cost of tanezumab fall into is divided into 3 main categories: administration, drug, and monitoring.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, the abuse of opioid analgesics in the United States has reached the point of affecting life expectancy, and new analgesics are urgently needed in the market. [34][35][36][37] As far as costs are concerned, the cost of tanezumab fall into is divided into 3 main categories: administration, drug, and monitoring. The cost of administration drugs refers to the cost associated with drug delivery and changes according to the setting (SC vs IV).…”

Section: Advantages and Disadvantage Of Tanezumab Treatmentmentioning

confidence: 99%

Different Dosage Regimens of Tanezumab for the Treatment of Chronic Low Back Pain: A Meta-analysis of Randomized Controlled Trials

Lian

Wang

et al. 2022

Clin Neuropharm

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ObjectiveThe aim of this study was to assess the efficacy of different dosage regimens of tanezumab among individuals living with chronic low back pain (CLBP).MethodsPubMed, Embase, The Cochrane Library, and other databases were searched from inception until August 2021. Randomized controlled trials investigating the efficacy and safety of tanezumab in individuals with CLBP were included. Data were extracted independently by 2 investigators and assessed the study quality by the Cochrane risk-of-bias tool. The measurements include low back pain intensity and Roland-Morris Disability Questionnaire. The incidence of adverse events and serious adverse events was set to assess the safety of tanezumab for CLBP.Results and DiscussionThree high-quality randomized controlled trials with 3414 patients were finally included in our analysis. Tanezumab, respectively, led to a notable decrease compared with placebo in low back pain intensity (mean difference, −0.62; 95% confidence interval [CI], −0.77 to −0.46; P < 0.01) and Roland-Morris Disability Questionnaire (mean difference, −0.64; 95% CI, −0.80 to −0.47; P = 0.01). In addition, no significant difference existed between tanezumab and placebo groups (risk ratio, 1.10; 95% CI, 0.81–1.49; P = 0.55) in the adverse events and (risk ratio, 1.06; 95% CI, 0.34–3.27; P = 0.93) serious adverse events.ConclusionsIntravenous and subcutaneous tanezumab injections as treatment for improving CLBP have promising clinical application as its great improvement on all efficacy and its controllable safety issues. Furthermore, intravenous and subcutaneous tanezumab injections were proved to achieve excellent and long-term curative effect on CLBP through our subgroup analysis and comparison.

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Endogenous opiates and behavior: 2022

Bodnar

2023

Peptides

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Short-term stress significantly decreases morphine analgesia in trigeminal but not in spinal innervated areas in rats

Cited by 3 publications

References 58 publications

The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

Different Dosage Regimens of Tanezumab for the Treatment of Chronic Low Back Pain: A Meta-analysis of Randomized Controlled Trials

Endogenous opiates and behavior: 2022

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