Short-term stability of T 1 and T 2 relaxation measures in multiple sclerosis normal appearing white matter

Liang, Alice L. W.; Vavasour, Irene M.; Mädler, Burkhard; Traboulsee, Anthony; Lang, Donna J.; Li, David K.B.; MacKay, Alex L.; Laule, Cornelia

doi:10.1007/s00415-011-6318-0

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…This study is one of the largest so far to report associations between any measured hippocampal integrity and cognitive ability (Adriano et al, 2012). Where previous studies have successfully applied these techniques to pathological conditions such as brain tumour or multiple sclerosis (Davies et al, 2004; Liang et al, 2012), Alzheimer’s disease (Hanyu et al, 2005; Hong et al, 2010; Ropele et al, 2012), dementia with lewy bodies (Hanyu et al, 2005) and cerebrovascular disease (Foerster et al, 2012), we have shown their usefulness in providing more sensitive measures of brain structure than volumetric analysis in detecting subtle associations with cognitive performance. Another strength of the study is the access to early life cognitive data, age 11 IQ, allowing us to control for prior ability when looking at associations between cognitive ability in later life and brain size.…”

Section: Discussionmentioning

confidence: 96%

Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects

Aribisala

Royle

Maniega

et al. 2014

Cortex

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Hippocampal structural integrity is commonly quantified using volumetric measurements derived from brain magnetic resonance imaging (MRI). Previously reported associations with cognitive decline have not been consistent. We investigate hippocampal integrity using quantitative MRI techniques and its association with cognitive abilities in older age.Participants from the Lothian Birth Cohort 1936 underwent brain MRI at mean age 73 years. Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocampus. General factors of fluid-type intelligence (g), cognitive processing speed (speed) and memory were obtained at age 73 years, as well as childhood IQ test results at age 11 years. Amongst 565 older adults, multivariate linear regression showed that, after correcting for ICV, gender and age 11 IQ, larger left hippocampal volume was significantly associated with better memory ability (β = .11, p = .003), but not with speed or g. Using quantitative MRI and after correcting for multiple testing, higher T1 and MD were significantly associated with lower scores of g (β range = −.11 to −.14, p < .001), speed (β range = −.15 to −.20, p < .001) and memory (β range = −.10 to −.12, p < .001). Higher MTR and FA in the hippocampus were also significantly associated with higher scores of g (β range = .17 to .18, p < .0001) and speed (β range = .10 to .15, p < .0001), but not memory.Quantitative multi-modal MRI assessments were more sensitive at detecting cognition-hippocampal integrity associations than volumetric measurements, resulting in stronger associations between MRI biomarkers and age-related cognition changes.

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Section: Discussionmentioning

confidence: 96%

Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects

Aribisala

Royle

Maniega

et al. 2014

Cortex

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“…Myelin water imaging was shown to have high reproducibility in healthy brains, both longitudinally and between imaging sites using the same scanner type and the same protocol [ 47 , 48 ]. Moreover, MWF in the normal appearing white matter of people with multiple sclerosis was also shown to be stable over at least six months [ 49 ]. In a guinea pig model of demyelination (experimental allergic encephalomyelitis), a decrease in the short T2 component was observed, which was consistent with histological myelin loss [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury – A Prospective Cohort Study in Collegiate Hockey Players

et al. 2016

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Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of neuroscience. Currently, the diagnosis and management of such injuries are based largely on patient-reported symptoms. An improved understanding of the underlying pathophysiology of mTBI is urgently needed in order to develop better diagnostic and management protocols. Specifically, dynamic post-injury changes to the myelin sheath in the human brain have not been examined, despite ‘compromised white matter integrity’ often being described as a consequence of mTBI. In this preliminary cohort study, myelin water imaging was used to prospectively evaluate changes in myelin water fraction, derived from the T2 decay signal, in two varsity hockey teams (45 players) over one season of athletic competition. 11 players sustained a concussion during competition, and were scanned at 72 hours, 2 weeks, and 2 months post-injury. Results demonstrated a reduction in myelin water fraction at 2 weeks post-injury in several brain areas relative to preseason scans, including the splenium of the corpus callosum, right posterior thalamic radiation, left superior corona radiata, left superior longitudinal fasciculus, and left posterior limb of the internal capsule. Myelin water fraction recovered to pre-season values by 2 months post-injury. These results may indicate transient myelin disruption following a single mTBI, with subsequent remyelination of affected neurons. Myelin disruption was not apparent in the athletes who did not experience a concussion, despite exposure to repetitive subconcussive trauma over a season of collegiate hockey. These findings may help to explain many of the metabolic and neurological deficits observed clinically following mTBI.

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“…Intra‐subject registration was performed with FLIRT (correlation ratio cost function, six degrees of freedom, trilinear interpolation) following the identification of the voxel location on the T I = 1500 ms IR‐ T 1 image and co‐registering all T I = 1500 ms IR‐ T 1 images and voxel maps to the 3D‐ T 1 of each volunteer (supplementary material). Following quality assurance, absolute metabolite concentrations, [met], were calculated based on voxel tissue composition, with corrections for water relaxation; for details please see the supplementary material. To avoid a bias in rejecting metabolite values from lower concentrations, individual metabolite measurements were only rejected if the absolute Cramér‐Rao lower bound error was greater than 30% of the median measured concentration …”

Section: Methodsmentioning

confidence: 99%

Intra‐ and inter‐site reproducibility of human brain single‐voxel proton MRS at 3 T

Graf

MacMillan

et al. 2019

NMR in Biomedicine

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Introduction Clinical trials that involve participants from multiple sites necessitate standardized and reliable quantitative MRI outcomes to detect significant group differences over time. Metabolite concentrations measured by proton MRS (1H‐MRS) provide valuable information about in vivo metabolism of the central nervous system, but can vary based on the acquisition and quantitation methods used by different MR sites. Therefore, we investigated the intra‐ and inter‐site reproducibility of metabolite concentrations measured by 1H‐MRS on MRI scanners from a single manufacturer across six sites. Methods Five healthy controls were scanned twice within 24 h at six participating 3 T MR sites with large single‐voxel PRESS (TE/TR/NSA = 36 ms/4000 ms/56) and anatomical images for voxel positioning and correction of partial volume relaxation. Absolute metabolite concentrations were calculated relative to the T1 and T2 relaxation corrected signal from water. Intra‐ and inter‐site reproducibility was assessed using Bland–Altman plots and intra‐ and inter‐site coefficient of variation (CoV) as well as intra‐ and inter‐site intra‐class correlation coefficient. Results The median intra‐site CoVs for the five major metabolite concentrations ([NAA], [tCr], [Glu], [tCho] and [Ins]) were between 2.5 and 5.3%. Inter‐site CoVs were also low, with the median CoVs for all metabolites between 3.7 and 6.4%. Metabolite concentrations were robust to small inconsistencies in voxel placement and site was not the driving factor in the variance of the measurement of any metabolite concentration. Between‐subject differences accounted for the majority of the concentration variability for creatine, choline and myo‐inositol (42–65% of the variance). Conclusion A large single‐voxel 1H‐MRS acquisition from a single manufacturer's MRI scanner is highly reproducible and reliable for multi‐site clinical trials.

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Short-term stability of T 1 and T 2 relaxation measures in multiple sclerosis normal appearing white matter

Cited by 14 publications

References 42 publications

Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects

Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects

Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury – A Prospective Cohort Study in Collegiate Hockey Players

Intra‐ and inter‐site reproducibility of human brain single‐voxel proton MRS at 3 T

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