Short-Term Stability in Refractive Status Despite Large Fluctuations in Glucose Levels in Diabetes Mellitus Type 1 and 2

Huntjens, Byki; Charman, W. N.; Workman, H.; Hosking, Sarah; O’Donnell, Clare

doi:10.1371/journal.pone.0052947

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Huntjens et al . showed that short‐term changes in blood glucose (~6 mmol/l over a few hours) had a minimal effect on central corneal thickness, anterior chamber depth, lens thickness, axial length and ocular aberrations.…”

Section: Refractionmentioning

confidence: 99%

“…Transient changes in refraction are well recognized in newly diagnosed people with diabetes, in the form of hyperopia [37,38] or myopia [39] or both, when hyperglycaemia is corrected [4] (Table 1 [4,[37][38][39][40][41][42][43][44]).…”

Section: Refractionmentioning

confidence: 99%

“…Changes in the lens refractive index are thought to be responsible for the refractive changes in people with diabetes [40]. Huntjens et al [41] showed that short-term changes in blood glucose (~6 mmol/l over a few hours) had a minimal effect on central corneal thickness, anterior chamber depth, lens thickness, axial length and ocular aberrations.…”

Section: Refractionmentioning

confidence: 99%

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Visual complications in diabetes mellitus: beyond retinopathy

et al. 2016

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Diabetic retinopathy is the most common cause of vision loss in people with diabetes mellitus; however, other causes of visual impairment/loss include other retinal and non-retinal visual problems, including glaucoma, age-related macular degeneration, non-arteritic anterior ischaemic optic neuropathy and cataracts. Additionally, when a person with diabetes complains of visual disturbance despite a visual acuity of 6/6, abnormalities in refraction, contrast sensitivity, straylight and amplitude of accommodation should be considered. We review and highlight these visual problems for physicians who manage people with diabetes to ensure timely referral and treatment to limit visual disability, which can have a significant impact on daily living, especially for those participating in sports and driving.

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Section: Refractionmentioning

confidence: 99%

Section: Refractionmentioning

confidence: 99%

Section: Refractionmentioning

confidence: 99%

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Visual complications in diabetes mellitus: beyond retinopathy

et al. 2016

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“…23 Huntjens, Charman and colleagues carried out a study to investigate how short term changes in blood glucose affect refractive components in individuals with type 1 and type 2 DM. 24 For this clinical study, 41 long-term diabetic and 20 non-diabetic (control) participants were recruited and data were collected throughout the day at broadly two-hourly intervals between 8.00 and 20.00 hours. Various clinical measurements including objective refraction, aberrations, anterior chamber depth, lens thickness and corneal thickness were collected, one eye of each participant was randomly selected for statistical analysis.…”

Section: Resultsmentioning

confidence: 99%

Auswirkungen von Diabetes mellitus und Hyperglykämie auf den refraktiven Status des Auges

Jonuscheit¹

2021

Optom Contact Lenses

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Purpose. Diabetes mellitus is a condition of considerable concern globally, which can affect the visual system in various ways, including changes to visual function, the integrity of the ocular surface and the retinal microcirculation. The aim of this article is to provide an overview on the perspectives around the relationship between diabetes and refractive status. Material and Methods. Narrative literature review. Results. The relationship between diabetes, hyperglycaemia and refractive error has been of interest to clinicians and researchers for more than a century. This review shows that research studies investigating the relationship have varied considerably in their design, methodology, their outcome measures used as well as their reported results. While some uncertainty remains, there is evidence that short-term, drastic changes in blood glucose levels affect the refractive status of human eyes leading to fluctuating and blurred vision. Conclusion. Patients starting glycaemic treatment or under- going adaptation to a new treatment regime may present with considerable refractive changes and visual complaints. Before considering the prescription of spectacle lenses, clinicians should ideally monitor patients in whom glycaemic control has been initiated or is being adjusted until a stabilisation of blood glucose levels has been confirmed. Keywords Diabetes, refraction, refractive error, variability

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“…The causes of declined visual quality in diabetic children and the factors leading to wavefront aberrations in diabetic children may be related to the cornea, tear lm, lens, or retina. For example, the more serious the injury to the paralacrimal gland cells in diabetic eyes is, the less the basic secretion of tears will be, which will further reduce the stability of the tear lm [23,24] . A long-term increase or instability in the glucose content in the aqueous humor of diabetic patients will lead to an increase in lactic acid concentration, changes in corneal glucose metabolism, metabolic acidosis of corneal stroma, and changes in corneal endothelial cell morphology and function [25] .…”

Section: Discussionmentioning

confidence: 99%

Wavefront Aberration Analysis in Diabetic Children and Adolescents with Normal Vision

Wang¹,

Jia²,

T³

et al. 2020

Preprint

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Background: To compare the differences in wavefront aberrations between healthy and diabetic children with normal central vision and to investigate the causes of declined visual quality in diabetic children.Methods: This was a case-control study. Children with or without diabetes with normal central vision were selected as case and control group. The wavefront aberration parameters, including spherical aberration, coma aberration, root mean square of total wavefront aberration, root mean square of higher-order wavefront aberration, and corneal curvature, were measured by an automatic multifunctional ophthalmoscope. Statistical analysis was performed to determine the differences in average binocular wavefront aberration between groups. The correlations between wavefront aberration and age, visual acuity, corneal endothelium, intraocular pressure, axial length, corneal diameter, central corneal thickness, crystal thickness, anterior and posterior surface curvatures, and anterior chamber depth were analyzed in the diabetic group.Results: 32 patients with diabetes and 38 age- and sex-matched individuals were enrolled. The mean total and higher-order aberrations in diabetic group were slightly higher than those in control group, with no significant difference between groups (P > .05). The root mean squares of the aberrations correlated with anterior and posterior surface curvatures (P3mm = .014, P5mm = .021; P3mm = .035, P5mm = .038, respectively), but not with age, visual acuity, corneal endothelium, intraocular pressure, axis, corneal diameter, central corneal thickness, crystal thickness, and anterior chamber depth.Conclusions: For diabetic children, subtle changes in lens may lead to changes in wavefront aberrations and this may be the causes of visual impairment. These findings indicate the need to strengthen early screening and close follow-up of wavefront aberrations in diabetic children.Trial registration: This was a case-control study based on a hospital population (NCT 03587948). Date of registration was 07/03/2018. The name of the registration is Shanghai Children and Adolescent Diabetes Eye Study.

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Short-Term Stability in Refractive Status Despite Large Fluctuations in Glucose Levels in Diabetes Mellitus Type 1 and 2

Cited by 14 publications

References 36 publications

Visual complications in diabetes mellitus: beyond retinopathy

Visual complications in diabetes mellitus: beyond retinopathy

Auswirkungen von Diabetes mellitus und Hyperglykämie auf den refraktiven Status des Auges

Wavefront Aberration Analysis in Diabetic Children and Adolescents with Normal Vision

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