Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus

Xie, Meilan; Yan, Jie; He, Chao; Yang, Li; Tan, Gang; Li, Chao; Hu, Zhian; Wang, Jiali

doi:10.1016/j.bbr.2015.02.040

Cited by 34 publications

(38 citation statements)

References 36 publications

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“…Moreover, sleep deprivation has been shown to have a detrimental effect on certain aspects of working memory, such as filtering efficiency, whilst Stroop test scores show degradation; however, this has been evidenced to be due to deficits in reaction time rather than processing skills [5,[11][12][13][14][15][16][17]. Taken together, these data suggest that sleep deprivation may have a limited effect on cognitive ability in university students.…”

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confidence: 80%

Effects of sleep deprivation on cognitive and physical performance in university students

et al. 2017

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using paired two-tailed T tests and MANOVA. Reaction time and systolic blood pressure post-exercise were significantly increased following sleep deprivation (mean ± SD change: reaction time: 0.15 ± 0.04 s, p = 0.003; systolic BP: 6 ± 17 mmHg, p = 0.012). No significant differences were found in other variables. Reaction time and vascular response to exercise were significantly affected by sleep deprivation in university students, whilst other cognitive and cardiopulmonary measures showed no significant changes. These findings indicate that acute sleep deprivation can have an impact on physical but not cognitive ability in young healthy university students. Further research is needed to identify mechanisms of change and the impact of longer term sleep deprivation in this population.

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Effects of sleep deprivation on cognitive and physical performance in university students

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“…After the 4 h SD, the brains of animals in the SD-treated and control groups were rapidly removed and sliced at 400 μm thick. The tissue of EC used for the present study is from the same animals that were reported in our previous study [13]. The EC regions were dissected according to the rat brain atlas of Paxinos and Watson.…”

Section: Surface Biotinylation Assaysmentioning

confidence: 99%

“…The methods for surface biotinylation and western blotting assays were similar to our previous report [13]. After the 4 h SD, the brains of animals in the SD-treated and control groups were rapidly removed and sliced at 400 μm thick.…”

Section: Surface Biotinylation Assaysmentioning

confidence: 99%

“…Acute or chronic SD has been reported to affect neuronal function [6] and cause deficits in the acquisition and consolidation of spatial reference memory in Morris water maze [7][8][9][10][11]. In addition, SD impaired the spatial working memory in radial maze [12], T-maze [13] and novel arm recognition tasks [14].…”

Section: Introductionmentioning

confidence: 98%

“…In parallel with the SD-induced changes in cognitive function, AMPARs and NMDARs have been reported to be vulnerable to SD in neocortex and hippocampus. A brief or chronic SD has been reported to alter the AMPARs and NMDARs, especially their subunit expression levels, in these brain regions [13,[29][30][31].…”

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confidence: 99%

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Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory

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et al. 2016

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Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During Sleep

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et al. 2024

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High‐frequency oscillatory activity in cognition‐related neural circuits during wakefulness consistently induces the growth of dendritic spines and axonal terminals. Although these structural changes are essential for cognitive functions, it is hypothesized that if these newly expanded structures fail to establish functional connections, they may become superfluous. Sleep is believed to facilitate the reduction of such redundant structures to maintain neural homeostasis. However, the mechanisms underlying this pruning process during sleep remain poorly understood. In this study, that melatonin type 3 receptors (MT3Rs) are selectively expressed in the stellate neurons of the medial entorhinal cortex (MEC) is demonstrated, an area where high melatonin levels are detected during sleep. Activation of MT3Rs during sleep initiates the shrinkage of dendritic spines in stellate neurons by downregulating neural network activity and dephosphorylating synaptic proteins in the MEC. This process is disrupted when MT3R expression is knocked down or when MT3Rs are blocked during sleep. Notably, interference with MT3Rs in the MEC during sleep impairs the acquisition of spatial memory but does not affect object memory acquisition following sleep. These findings reveal novel molecular mechanisms involving melatonin and MT3Rs in the regulation of dendritic spine shrinkage during sleep, which is crucial for the acquisition and consolidation of spatial memory.

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Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus

Cited by 34 publications

References 36 publications

Effects of sleep deprivation on cognitive and physical performance in university students

Effects of sleep deprivation on cognitive and physical performance in university students

Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory

Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During Sleep

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