Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men

Poulsen, Morten; Ørnstrup, Marie Juul; Harsløf, Torben; Jessen, Niels; Langdahl, Bente; Richelsen, Bjørn; Jørgensen, Jens Otto Lunde; Pedersen, Steen B.

doi:10.1016/j.jff.2013.10.019

Cited by 26 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Mohaved A and colleagues failed to detect a difference in alkaline phosphatase levels after high dose resveratrol (1000 mg/day) treatment for 45 days in their cohort of adults with type 2 diabetes mellitus (Mohaved et al, 2013). In contrast, Poulsen and colleagues reported significant and borderline significant increases in bone-specific and total alkaline phosphatase levels, respectively, after resveratrol treatment (1500 mg/day) in their study of obese, non-diabetic men (Poulsen et al, 2014). It is worth noting, however, that the elevations in alkaline phosphatase levels observed in our study were still within the normal range, and thus we do not believe the elevated levels of alkaline phosphatase in the high dose group are a cause for concern at the present time.…”

Section: Discussionmentioning

confidence: 88%

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

Anton

Embry²,

Marsiske

et al. 2014

Experimental Gerontology

View full text Add to dashboard Cite

Resveratrol has been found to have potent antioxidant, anti-inflammatory, and anticarcinogenic effects. The safety and efficacy of resveratrol supplementation in older adults are currently unknown. We conducted a double-blind, randomized, placebo-controlled trial to examine the safety and metabolic outcomes in 32 overweight, older adults (mean age, 73 ± 7 years). Participants were randomized into one of three treatment groups: (1) placebo, (2) moderate dose resveratrol (300 mg/day), and (3) high dose resveratrol (1000 mg/day). Both resveratrol and placebo were orally ingested in capsule form twice daily for 90 days. Blood chemistry values remained within the normal range, and there were no significant differences in the number of participants reporting adverse events across conditions. Compared to placebo, glucose levels were significantly lower at post-treatment among participants randomized to both resveratrol conditions, with and without adjustment for the corresponding baseline values (ps < 0.05). Glucose values of participants in the treatment groups, however, were not significantly different from baseline levels. These findings suggest that short-term resveratrol supplementation at doses of 300 mg/day and 1000 mg/day does not adversely affect blood chemistries and is well tolerated in overweight, older individuals. These findings support the study of resveratrol for improving cardio-metabolic health in older adults in larger clinical trials.

show abstract

Section: Discussionmentioning

confidence: 88%

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

Anton

Embry²,

Marsiske

et al. 2014

Experimental Gerontology

View full text Add to dashboard Cite

show abstract

“…Resveratrol (3,5,4′-trihydroxystilbene or 3,5,4′-stilbenetriol; MW: 228.25) is a stilbene compound, catalogued as a polyphenol, that has attracted considerable attention due to several in vitro and in vivo studies which emphasize its health benefits (Poulsen et al, 2014;Wu, Yang, Wang, & Wang, 2013). Red wines are the most notable dietary source of resveratrol and usually contain an average resveratrol concentration of 1.9 ± 1.7 mg/L (Fernández-Mar, Mateos, García-Parrilla, Puertas, & Cantos-Villar, 2012), although its concentrations may range from undetectable to 14.3 mg/L (Mark, Nikfardjam, Avar, & Ohmacht, 2005).…”

Section: Introductionmentioning

confidence: 99%

Autochthonous yeasts with β-glucosidase activity increase resveratrol concentration during the alcoholic fermentation of Vitis labrusca grape must

Gaensly

Agustini

Silva

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

Available online A B S T R A C TSince red wine is the main dietary source of resveratrol, a well-known polyphenol that reduces coronary events in humans, different strategies have been employed in winery to achieve resveratrol-enriched wines. Yeasts-endowed β-glucosidase activity enhances freeresveratrol concentration in wine without modifying its composition or sensorial properties.Current assay screened 308 autochthonous yeast strains for β-glucosidase activity employing arbutin, esculin, cellobiose and piceid as substrates. The β-glucosidase-producer yeasts were evaluated in the must of Vitis labrusca Bordô grape to quantify resveratrol concentration before and after alcoholic fermentation. Fourteen yeasts increased the resveratrol concentration up to 102% without any significant difference and nine of these yeast strains also produced high ethanol contents. Four autochthonous Hanseniaspora uvarum β-glucosidaseproducer strains showed adequate oenological characteristics and hydrolysed resveratrolglucosides during the alcoholic fermentation of V. labrusca grape must.

show abstract

“…The main features of the studies included in the current meta‐analysis are described in Table . Overall, eight effect sizes were extracted from six RCTs that included a total of 264 subjects, of which 149 subjects were in the resveratrol group and 115 belonged to the control group . The mean age of participants in these studies ranged from 49 to 73 years.…”

Section: Resultsmentioning

confidence: 99%

“…These studies were published between 2013 and 2017. The RCTs were conducted in Iran, India, Denmark, and the United States . The dose of resveratrol ranged from 150 to 1500 milligrams per day.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis

Asis

Hemmati

Moradi

et al. 2019

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The current study presents a comprehensive systematic review and meta‐analysis of randomized controlled trials (RCTs) on resveratrol and bone health biomarkers. PubMed, Scopus, and Web of Science (until September 2018) were searched to identify the potential RCTs with information on resveratrol supplementation and bone metabolism biomarkers. Mean differences (MD) were analyzed using a random‐effects model. Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C‐terminal telopeptide of type I collagen, and procollagen I N‐terminal propeptide values after resveratrol supplementation over placebo treatment. However, a significant increase in serum alkaline phosphatase (ALP) (MD: 5.69 mg/mL, 95% CI: 3.58–7.80, I2 = 95.7%, P < 0.001) and bone alkaline phosphatase (BAP) (MD: 10.57 mmHg, 95% CI: 5.36–15.78, I2 = 99.2%, P < 0.001) values was observed after resveratrol treatment relative to placebo. The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP. Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.

show abstract

Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men

Cited by 26 publications

References 20 publications

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

Autochthonous yeasts with β-glucosidase activity increase resveratrol concentration during the alcoholic fermentation of Vitis labrusca grape must

Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis

Contact Info

Product

Resources

About