Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults

Stone, Michael S.; Martin, Berdine R.; Weaver, Connie M.

doi:10.3390/nu13051610

Cited by 7 publications

(10 citation statements)

References 43 publications

(57 reference statements)

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“…Supporting this idea, in other studies where SBP has been reduced via K + supplementation, microvascular and endothelial function are not altered (66,67). Together, based on our current data, this points to a limited direct role of the vasculature in modulating BP changes in response to various dietary K + loads.…”

Section: Discussionsupporting

confidence: 81%

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

et al. 2023

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Dietary potassium (K + ) supplementation is associated with a blood pressure (BP) lowering effect, but not all studies agree. Here we examined the effects of short and long-term K + supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na + ) intake and molecular alterations in the kidney that may underlie BP changes.Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na + ) for 7 weeks or 2 weeks with a K + -free diet. BP was highest on a K + -free/high NaCl diet. Commensurate with increased abundance and phosphorylation of the thiazide sensitive sodium-chloridecotransporter (NCC) on the K + -free/high NaCl diet, BP returned to normal with thiazides.Three weeks of a high K + diet (5% K + ) increased BP (predominantly during night-time) independently of dietary Na + or anion intake. Conversely, 4 days of KCl feeding reduced BP.Both feeding periods resulted in lower NCC levels, but increased levels of cleaved (active) α and γ subunits of the epithelial Na + channel ENaC. The elevated BP after chronic K + feeding was reduced by amiloride but not thiazide. Our results suggest that dietary K + has an optimal threshold where it may be most effective for cardiovascular health.

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Section: Discussionsupporting

confidence: 81%

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

et al. 2023

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“…Study procedures have been described elsewhere [29]. Briefly, subjects were prehypertensive-to-hypertensive (systolic blood pressure >120 mmHg) men and women (n = 30, age 21 y and older).…”

Section: Subjectsmentioning

confidence: 99%

“…The parent study was a randomized, controlled feeding trial with cross-over design and primary outcomes of potassium balance and blood pressure (reported elsewhere [29]). Secondary measures assessed in this report included Ca excretion and Ca balance.…”

Section: Dietary Interventionmentioning

confidence: 99%

“…General procedures for measurement of mineral excretion and retention have been described previously [29]. Twenty-four-hour urine and feces were collected in acid washed containers.…”

Section: Calcium Balance and Net Absorptionmentioning

confidence: 99%

“…The purpose of this paper is to report findings of the secondary outcomes of a randomized, controlled feeding trial designed primarily to examine the effect of increased dietary potassium from potato sources and a potassium-gluconate supplement compared to a control diet on blood pressure. The primary outcomes have been previously reported [29]. The research in this report aimed to assess the effect of increased dietary potassium from potato sources and a potassium-gluconate supplement on the Ca economy compared to a control diet.…”

Section: Introductionmentioning

confidence: 99%

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Short-Term Supplemental Dietary Potassium from Potato and Potassium Gluconate: Effect on Calcium Retention and Urinary pH in Pre-Hypertensive-to-Hypertensive Adults

2021

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Potassium supplementation has been associated with reduced urinary calcium (Ca) excretion and increased Ca balance. Dietary interventions assessing the impact of potassium on bone are lacking. In this secondary analysis of a study designed primarily to determine blood pressure effects, we assessed the effects of potassium intake from potato sources and a potassium supplement on urinary Ca, urine pH, and Ca balance. Thirty men (n = 15) and women (n = 15) with a mean ± SD age and BMI of 48.2 ± 15 years and 31.4 ± 6.1 kg/m2, respectively, were enrolled in a cross-over, randomized control feeding trial. Participants were assigned to a random order of four 16-day dietary potassium interventions including a basal diet (control) of 2300 mg/day (~60 mmol/day) of potassium, and three phases of an additional 1000 mg/day (3300 mg/day(~85 mmol/day) total) of potassium in the form of potatoes (baked, boiled, or pan-heated), French fries (FF), or a potassium (K)-gluconate supplement. Calcium intake for all diets was approximately 700–800 mg/day. Using a mixed model ANOVA there was a significantly lower urinary Ca excretion in the K-gluconate phase (96 ± 10 mg/day) compared to the control (115 ± 10 mg/day; p = 0.027) and potato (114 ± 10 mg/day; p = 0.033). In addition, there was a significant difference in urinary pH between the supplement and control phases (6.54 ± 0.16 vs. 6.08 ± 0.18; p = 0.0036). There were no significant differences in Ca retention. An increased potassium intake via K-gluconate supplementation may favorably influence urinary Ca excretion and urine pH. This trial was registered at ClinicalTrials.gov as NCT02697708.

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Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Křížkovská

Viktorová

Lipov

2022

J. Agric. Food Chem.

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Potatoes (Solanum tuberosum) are one of the most important crops worldwide. However, its production and nutrient content are endangered by both biotic and abiotic stresses. The main yield losses are caused by pest damage (e.g., Colorado potato beetle and aphids), virus disease (e.g., Potato leafroll virus and Potato viruses Y and X), or oomycete pathogens (like Phytophthora infestans), which also significantly affect the production of antinutrients and toxic metabolites of plants. Therefore, the use of genetic engineering could be an efficient tool, not harmful to the environment, and beneficial to the consumer. In this review, we focus on the main sources of problems in the field of potato production according to approved genetic modifications, their traditional solution and positive impact of gene transfection reducing economic losses, use of insecticides, and improving the nutritional properties of potatoes. We summarize all transgenic events that have been performed on potatoes and have been approved for cultivation and/or direct use or processing as feed or food.

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Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults

Cited by 7 publications

References 43 publications

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Short-Term Supplemental Dietary Potassium from Potato and Potassium Gluconate: Effect on Calcium Retention and Urinary pH in Pre-Hypertensive-to-Hypertensive Adults

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

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