Short-term plasticity of the human adult visual cortex measured with 7T BOLD

Binda, Paola; Kurzawski, Jan W.; Lunghi, Claudia; Biagi, Laura; Tosetti, Michela; Morrone, MC

doi:10.1101/323741

Cited by 4 publications

(8 citation statements)

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“…2017), and continuous flash suppression (Kim, Kim, & Blake, 2017). The shift in ocular dominance has been confirmed with EEG (Zhou, Baker, Simard, Saint-Armour, & Hess, 2015), fMRI (Binda et al, 2018), MEG (Chadnova, Reynaud, Clavagnier, & Hess, 2017), and various psychophysical tasks Spiegel, Baldwin, & Hess, 2017;Zhou, Clavagnier, & Hess, 2013). For their study on the effect of exercise, Lunghi and Sale measured the ocular dominance shift with a binocular rivalry paradigm.…”

Section: Introductionmentioning

confidence: 83%

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

et al. 2019

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Experiments using enriched environments have shown that physical exercise modulates visual plasticity in rodents. A recent study (Lunghi & Sale, 2015) investigated whether exercise also affects visual plasticity in adult humans. The plastic effect they measured was the shift in ocular dominance caused by 2 hr of monocular deprivation (e.g., by an eye patch). They used a binocular rivalry task to measure this shift. They found that the magnitude of the shift was increased by exercise during the deprivation period. This effect of exercise was later disputed by a study that used a different behavioral task (Zhou, Reynaud, & Hess, 2017). Our goal was to determine whether the difference in task was responsible for that study's failure to find an exercise effect. We set out to replicate Lunghi and Sale (2015). We measured ocular dominance with a rivalry task before and after 2 hr of deprivation. We measured data from two conditions in 30 subjects. On two separate days, they either performed exercise or rested during the deprivation period. Contrary to the previous study, we find no significant effect of exercise. We hypothesize that exercise may affect rivalry dynamics in a way that interacts with the measurement of the deprivation effect.

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Section: Introductionmentioning

confidence: 83%

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

et al. 2019

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“…On the cortical visual areas, the short-term effect of MD in extrastriate visual cortex has been rarely investigated. Binda et al (2018) observed enhanced BOLD responses to a broadband stimulus presented to the deprived eye in the ventral visual stream. However, this effect may have been inherited from V1.…”

Section: Introductionmentioning

confidence: 92%

“…In the binocular condition, DEand NDE-biased responses were defined as the ROI-averaged responses of DE-and NDE-biased voxels (voxels with significant DE-NDE responses in the localizer), respectively. responses (Binda et al, 2018;Lunghi et al, 2015). The most likely reason underlying this discrepancy is the saturation of BOLD responses at high contrast levels (see results of experiment 3 and discussion for details).…”

Section: No Significant Deprivation Effect Was Found In V1mentioning

confidence: 98%

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Two opposing yet complementary ocular dominance plasticity: thalamus strengthens the weak channel while higher cortex listens to the strong signal

Zhang,

Qian,

Sun

et al. 2024

Preprint

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Monocular patching improves the non-patched eye in clinical practice, while recent laboratory evidence suggests that short-term patching strengthens the patched eye instead. The neural mechanisms underlying these opposite effects remain elusive. Using high-resolution 7T fMRI, we found two rapid and opposing mechanisms in the visual thalamus and higher visual cortex in response to monocular contrast deprivation (MCD) in human adults. Short-term MCD shifted ocular dominance of BOLD responses in favor of the deprived eye (DE) in the lateral geniculate nucleus and the ventrolateral pulvinar of the thalamus. Perceptually, DE became more sensitive in contrast detection and more dominant in binocular combination. In higher visual cortices, MCD shifted ocular dominance towards the nondeprived eye (NDE) in BOLD responses and their connectivity from V1. The 3-D shape perception was more accurate from shading cues presented to NDE compared to DE following deprivation. These findings demonstrate that a homeostatic gain modulation mechanism in the thalamus concurrently operates with a rapid Hebbian-like mechanism in the higher cortex to adaptively adjust interocular balance to abnormal binocular input.

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“…Comparable effects occur in adults with amblyopia (Zhou et al, 2013c). This has been extensively studied using psychophysics (Lunghi et al, 2011;Lunghi et al, 2013;Zhou et al, 2013a;Zhou et al, 2013c;Zhou et al, 2014) (Lunghi and Sale, 2015;Zhou and Hess, 2016;Zhou et al, 2017a;Zhou et al, 2017b), electrophysiology (Lunghi et al, 2015a;Zhou et al, 2015) and brain imaging (Lunghi et al, 2015b;Chadnova et al, 2017;Binda et al, 2018). There is evidence that it involves a reciprocal change in sensitivity of each eye's input; the previously patched eye becomes more dominant and the previously unpatched eye becomes less dominant, i.e., a homeostatic form of plasticity (Zhou et al, 2013a;Chadnova et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Can ocular dominance plasticity provide a general index to visual plasticity to personalize treatment in amblyopia?

Tao

Chen

et al. 2020

Preprint

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Purpose: Recently, Lunghi et al showed that amblyopic eye's visual acuity per se after 2 months of occlusion therapy could be predicted by a homeostatic plasticity, i.e., the temporary shift of ocular dominance observed after a 2-hour monocular deprivation, in children with anisometropic amblyopia (Lunghi et al., 2016). In this study, we assess whether the visual acuity improvement of the amblyopic eye measured after 2 months of occlusion therapy could be predicted by this plasticity. Methods: Seven children (6.86 ± 1.46 years old; SD) with anisometropic amblyopia participated in this study. All patients were newly diagnosed and had no treatment history before participating in our study. They had finished 2 months of refractive adaptation and then received a 4-hour daily fellow eye patching therapy with an opaque patch for a 2-month period. Best-corrected visual acuity of the amblyopic eye was measured before and after the patching therapy. The homeostatic plasticity was assessed by measuring the temporary shift of ocular dominance observed after 2 hours of occlusion for the amblyopic eye before the treatment started. A binocular phase combination paradigm was used for this test. Results: We found that there was no significant correlation between the temporary shift of ocular dominance observed after 2 hours of occlusion for the amblyopic eye before the treatment started and the visual acuity gain obtained by the amblyopic eye from 2-month of classical patching therapy. This result involving the short-term patching of the amblyopic eye is consistent with a reanalysis of Lunghi et al's data. Conclusions: Ocular dominance plasticity does not provide an index of cortical plasticity in the general sense such that it could be used to predict acuity outcomes from longer term classical patching.

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Short-term plasticity of the human adult visual cortex measured with 7T BOLD

Cited by 4 publications

References 89 publications

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

Visual plasticity and exercise revisited: No evidence for a “cycling lane”

Two opposing yet complementary ocular dominance plasticity: thalamus strengthens the weak channel while higher cortex listens to the strong signal

Can ocular dominance plasticity provide a general index to visual plasticity to personalize treatment in amblyopia?

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