Short-term physiological effects of a xenobiotic mixture on the freshwater mussel Elliptio complanata exposed to municipal effluents

Farcy, Émilie; Gagné, François; Martel, Louis; Fortier, Michelle; Trépanier, Sonia; Brousseau, Pauline; Fournier, Michel

doi:10.1016/j.envres.2011.07.009

Cited by 44 publications

(26 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous experiments using caged Elliptio complanata downstream a municipal effluent have stressed a modulation of immune response and induction of detoxification metabolism. 3 The present study confirmed the relevancy of the caging approach to investigate the short term ecotoxicological effects of municipal effluent.…”

Section: Resultssupporting

confidence: 62%

“…The use of caged mussels has been proved to be a convenient and efficient approach to assess the biological effects of a discharge mixture in the field without prior information on its chemical composition. 3 Particularly, the use of indigenous species such as Elliptio complanata is relevant to gain knowledge concerning wild species chronically exposed to the effluent. 4,5 Genotoxicity endpoints deserve to be studied since it is noteworthy that genotoxic impacts can lead to heritable mutations with potentially detrimental effects on aquatic organism populations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genotoxic impact of a municipal effluent dispersion plume in the freshwater mussel Elliptio complanata: an in situ study

Lacaze¹,

Devaux²,

Bony³

et al. 2013

J Xenobiotics

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Genotoxic impact of a municipal effluent dispersion plume in the freshwater mussel Elliptio complanata: an in situ study

Lacaze¹,

Devaux²,

Bony³

et al. 2013

J Xenobiotics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Toxicity of raw and treated wastewater has been demonstrated in previous research (Farcy et al, 2011;Gagné et al, 2011;Macova et al, 2011). Persistent organic pollutants (POPs) like polychlorinated biphenyls, organochlorine pesticides, and polycyclic aromatic hydrocarbons are typically responsible for many of the toxic effects of wastewater and are characterised by persistence, resisting chemical and biological degradation; the most effective means of removal seems to be dissolved organic carbon (DOC), powder activated carbon (PAC) and ozonation (Bolong et al, 2009;Katsoyiannis and Samara, 2007a;Stalter et al, 2011).…”

mentioning

confidence: 99%

Oestrogen, testosterone, cytotoxin and cholinesterase inhibitor removal during reclamation of sewage to drinking water

Faul

Julies

Pool

2013

WSA

View full text Add to dashboard Cite

Namibia is the driest sub-Saharan country in Africa. Namibia's capital, Windhoek, reclaims sewage water for domestic use at the Goreangab Water Reclamation Plant (GWRP). Risks associated with sewage effluent and reclaimed sewage should be closely monitored; therefore water at the Gammams Sewage Treatment Plant (GSTP) inlet and outlet, as well as reclaimed water from the GWRP, were assayed using selected bioassays. Samples collected were analysed using enzyme-linked immunosorbent-assays and chromogenic tests for steroid hormones, neurotoxicity, cytotoxicity and inflammatory activity. Estradiol level at the sewage treatment inlet was 78 pg/mℓ and the treated sewage level showed an 83% to 95% reduction in this, while after reclamation the level was below detection limit. Estrone concentrations at the sewage treatment inlet ranged from 10 to 161 pg/mℓ. Sewage treatment reduced estrone by between 85% and 92%. After reclamation the level of estrone was below detection limit. Testosterone ranged between 162 and 405 pg/mℓ at the sewage plant inlet. Sewage treatment removed 96% of the initial testosterone. The residual testosterone was effectively removed by processes in GWRP and after reclamation no testosterone was detected in water. Acetylcholinesterase (AChE) inhibition at the sewage treatment inlet was 50% while it was only 27% after sewage treatment. After reclamation AChE inhibition was not detected. Only water at the sewage inlet in March and February showed cytotoxicity. High inflammatory activity was detected at the sewage plant inlet. Sewage treatment reduced inflammatory activity by 64%. After reclamation low inflammatory activity was induced. Treated sewage used for reclamation tested positive for most of the biomarkers and can pose a risk to human health. However, reclamation successfully removed these contaminants. Due to the presence of contaminants in the intake water at the reclamation plant, it is essential to routinely monitor the water produced by the reclamation plant for potential residues that can adversely affect human health.

show abstract

“…Downregulation of proteins involved in the immune system (Galloway and Depledge, 2001;Gomes et al, 2014;Renault, 2015) has been described considerably more frequently than their upregulation (Maria and Bebianno, 2011). However, some studies have also described an initial period of immunostimulation followed by a period of immunosuppression, which occurs when the immune system can no longer cope with the stress (Farcy et al, 2011). Accordingly, the duration and intensity of exposure seem to be determinant in the observed response.…”

Section: Energy Metabolismmentioning

confidence: 88%

Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis

Oliveira¹,

Groh

Stadnicka-Michalak

et al. 2016

Aquatic Toxicology

View full text Add to dashboard Cite

Antifouling (AF) systems are used worldwide as one of the most cost-effective ways of protecting submerged structures against heavy biofouling. The emergence of environmentally friendly AF biocides requires knowledge on their environmental fate and toxicity. In this study we measured the bioconcentration of the emerging AF biocide tralopyril (TP) in the Mediterranean mussel Mytilus galloprovincialis and investigated the effects of TP on the mussel gill proteome following acute (2days) and chronic (30days) exposure, as well as after a 10-day depuration period. The experiments were carried out with 1μg/L TP; blank and solvent (5×10(-5)% DMSO) controls were also included. Proteomics analysis was performed by mass spectrometry-based multidimensional protein identification technology (MudPIT). Differentially expressed proteins were identified using a label-free approach based on spectral counts and G-test. Our results show that TP is rapidly accumulated by mussels at concentrations up to 362ng/g dw (whole tissues), reaching steady-state condition within 13days. Ten days of depuration resulted in 80% elimination of accumulated TP from the organism, suggesting that a complete elimination could be reached with longer depuration times. In total, 46 proteins were found to be regulated in the different exposure scenarios. Interestingly, not only TP but also DMSO alone significantly modulated the protein expression in mussel gills following acute and chronic exposure. Both compounds regulated proteins involved in bioenergetics, immune system, active efflux and oxidative stress, often in the opposite way. Alterations of several proteins, notably several cytoskeletal ones, were still observed after the depuration period. These may reflect either the continuing chemical effect due to incomplete elimination or an onset of recovery processes in the mussel gills. Our study shows that exposure of adult mussels to sublethal TP concentration results in the bioconcentration of this biocide in the tissues and modulates the expression of several proteins that may intervene in important metabolic pathways.

show abstract

Short-term physiological effects of a xenobiotic mixture on the freshwater mussel Elliptio complanata exposed to municipal effluents

Cited by 44 publications

References 83 publications

Genotoxic impact of a municipal effluent dispersion plume in the freshwater mussel Elliptio complanata: an in situ study

Genotoxic impact of a municipal effluent dispersion plume in the freshwater mussel Elliptio complanata: an in situ study

Oestrogen, testosterone, cytotoxin and cholinesterase inhibitor removal during reclamation of sewage to drinking water

Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis

Contact Info

Product

Resources

About