Short-Term Performance of Mitral Valve Replacement with Porcine Bioprosthetic Valves in Dogs

Abstract

ABSTRACT. Porcine bioprosthetic valves cross-linked with glutaraldehyde and polyepoxy compound were newly developed for mitral valve replacement (MVR) in dogs. Five beagle dogs were performed a left thoracotomy and underwent MVR using the porcine bioprosthetic valves during cardiopulmonary bypass (CPB). A vein catheter inserted into right atrium and a vent catheter inserted into the right ventricle to drain. The hemodynamic conditions of CPB were excellent during surgery. The left atrial pressure was measured before and after MVR; there was no significant difference and it was normal. Thrombosis and the prosthetic valve regurgitation were not observed one week after MVR. Pressure half time (PHT) prolonged significantly (P<0.05) from 31.40 ± 4.0 msec presurgery to 99.20 ± 19.4 msec at seven days after MVR, although it indicated the normal range as the bioprosthetic valve. The symptom of the prosthetic valve failure was not observed. This study indicated that the MVR using porcine bioprosthetic valves under CPB might have been effective in dogs as a short-term evaluation. KEY WORDS: bioprosthetic valve, canine cardiopulmonary bypass, mitral regurgitation, mitral valve replacement.

Long-Term Clinical Evaluation of Mitral Valve Replacement with Porcine Bioprosthetic Valves in Dogs

“…Short-term complications after MVR consists mainly of thrombosis that related to anticoagulation therapy, however, long-term complications are related to the durability and the antithrombogenicity of the bioprosthetic valve [20]. Therefore, as a first step, the performance of the newly developed porcine bioprosthetic valves were evaluated in a previous study, with resultant good results during short-term evaluation [21]. In this study, long-term performance was investigated and the durability and antithrombogenicity of the developed bioprosthetic valve were evaluated clinically.…”

“…The valves, with similar dimensions to that of canine mitral valves, were used (22.5 ± 0.9 mm). The valves and the protocols followed for MVR were in accordance with previous study [21,26]. …”

“…MVR procedures under cardiopulmonary bypass (CPB) and the use of the newly developed porcine bioprosthetic valves were shown to have been effective in dogs during short-term evaluation [21]. The aim of this study was to evaluate the long-term clinical performance of newly developed porcine bioprosthetic valves for mitral valve replacement (MVR) in dogs.…”

Challenges of Cardiopulmonary Bypass—A Review of the Veterinary Literature

“…Cardiopulmonary bypass (CPB) has been used inconsistently since the late 1960s in veterinary medicine to repair some of the most common intracardiac conditions that occur in dogs and cats . In animals, heart surgery has been performed in experimental settings and to address congenital and acquired conditions, such as ventricular septal defects, double chamber right ventricle, Tetralogy of Fallot, and mitral valve disease . When performing CPB in dogs and cats, there are important factors to consider: the different anatomy of the thoracic cavities requiring different types of cannulation, the dramatic variability in size and body conformation, the limited blood volume in small patients, the difference in coagulation and hemostasis compared with human patients, the limited availability of blood products, and the cost associated with their use.…”

Avaliação da expressão da conexina 43 no miocárdio de cães indenes submetidos ou não à técnica de circulação extracorpórea

“…(KLEMENT et al, 1987b;EYSTER, 1988;EYSTER et al, 1993). Posteriormente, alguns estudos relatam sucessos nas intervenções cirúrgicas realizadas com o uso da CEC (ORTON et al, 2001;BORESTEIN et al, 2004;HIRAO et al, 2004;TAKASHIMA et al, 2007;TAKASHIMA et al, 2008 A insuficiente ventilação pulmonar pode justificar a elevação dos níveis de CO 2 verificada no sangue arterial e venoso, conforme identificado em estudos anteriores (NIEMAN et al, 1999;LIU et al, 2000;. Os altos valores de PaCO 2 podem estar relacionados à maior concentração de catecolaminas circulantes e em conseqüência disso, maior incidência de alterações cardíacas CORTOPASSI, 2002).…”