Short-term outcomes of the new intragastric balloon End-Ball for treatment of obesity.

Abstract

IntroductionIntragastric balloons (IGBs) have been successfully used to treat obesity for the last 18 years. These balloons are made of different materials and filled with either air or saline. It seems that balloons filled with saline result in more effective weight loss, but are associated with worse tolerance after implantation. In contrast, balloons filled with air are associated with excellent tolerance, but result in less effective weight loss.AimTo report the early safety and effectiveness results of the End-Ball® balloon and to encourage discussions on how to best use this new-generation IGB for endoscopic weight loss management.Material and methodsTwenty obese patients (mean age: 40.5 years; mean body mass index: 34.8 kg/m2) were included in a 6-month study. Balloons were inflated with 300 ml of saline containing 5 ml of methylene blue and 300 cm3 of air.ResultsNo serious adverse events occurred during treatment. Patients experienced varying degrees of nausea, vomiting (mean: 3.7 times the first day), and abdominal pain after implantation. Six months (23–29 weeks) after End-Ball® balloon insertion, we observed a significant decrease in body weight (13.9 ±5.1 kg) and percent excess weight loss (37.9 ±12.9%). We also found a significant decrease in the levels of glycated hemoglobin (p < 0.001), C-peptide (p < 0.002), and triacylglycerols (p < 0.001) and an increase in the concentration of high-density lipoprotein cholesterol (p < 0.025).ConclusionsThe End-Ball® IGB is a safe and effective treatment for morbid obesity, with positive effects on weight loss and saccharide metabolism.

Various Intragastric Balloons Under Clinical Investigation

“…Buzga et al reported a mean weight loss amount of 14.7 kg with 32.1% EWL in 20 patients in 6 months [ 40 ]. The results were similar to those of conventional balloons with a low incidence rate of complications [ 40 ].…”

“…Buzga et al reported a mean weight loss amount of 14.7 kg with 32.1% EWL in 20 patients in 6 months [ 40 ]. The results were similar to those of conventional balloons with a low incidence rate of complications [ 40 ]. Keren and Rainis recently reported a mean weight loss amount of 23.5 kg, a mean BMI reduction of 6.4 kg/m 2 , and an EWL of 39.2% in 114 patients who were treated with the End-ball; the significant weight loss continued for 1 year after balloon removal [ 19 ].…”

Effects of Intragastric balloon on obesity in obese Korean women for 6 months post removal

“…The Bioenteric intragastric balloon (BIB), also known as ORBERA, has been most widely used in IGB treatment. BIB is made of silicone, which is thicker than polyethylene, and the balloon volume is thus signi cantly bigger and has a high incidence of complications [32]. Buzga et al [32] reported a mean weight loss of 13.9 kg with an EWL of 37.9% in 20 patients in 6 months after End-ball treatment.…”

“…BIB is made of silicone, which is thicker than polyethylene, and the balloon volume is thus signi cantly bigger and has a high incidence of complications [32]. Buzga et al [32] reported a mean weight loss of 13.9 kg with an EWL of 37.9% in 20 patients in 6 months after End-ball treatment. Keren and Rainis [33] reported a mean weight loss of 23.5 kg and 39.2% EWL in 114 subjects who were treated the End-ball; the weight loss signi cantly continued for 1 year after End-ball removal.…”

Mechanical intestinal obstruction caused by displacement of a stomach balloon - case report.

“…Among various approaches to treating obesity, endoscopic methods are used in selected cases, including endoscopically placed intragastric balloons (IGBs). The IGB therapy is used as a bridge to definitive treatment, to facilitate weight loss and optimal patient management prior to bariatric surgery [ 4 , 5 ]. Also, it is used to treat extremely obese patients with multiple comorbidities.…”