Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee

Kanchanatawan, Wichan; Arirachakaran, Alisara; Chaijenkij, Kornkit; Prasathaporn, Niti; Boonard, Manusak; Piyapittayanun, Peerapong; Kongtharvonskul, Jatupon

doi:10.1007/s00167-015-3784-4

Cited by 102 publications

(85 citation statements)

References 33 publications

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“…As the CI included 0, we are not able to say PRP is more effective than HA on relieving WOMAC pain and increasing physical function. In this case, the conclusions drawn from the two approaches are contradicting, but our findings were similar to another recent meta-analysis by Kanchanatawan et al 7 They reported that PRP injections had no significant differences in improving WOMAC pain and function scores when compared to HA injections, but had improved functional outcomes in WOMAC total scores, International Knee Documentation Committee (IKDC) score and EuroQol visual analogue scale (EQ-VAS), also suggesting that PRP injections were more efficacious than HA in reducing symptoms, and improving function and quality of life.…”

supporting

confidence: 78%

Platelet-rich plasma injection is not more effective than hyaluronic acid to treat knee osteoarthritis when using a random-effects model

Wang

Liu

2016

Br J Sports Med

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supporting

confidence: 78%

Platelet-rich plasma injection is not more effective than hyaluronic acid to treat knee osteoarthritis when using a random-effects model

Wang

Liu

2016

Br J Sports Med

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“…Nonetheless, most comparisons included only 1 or 2 studies due to the small number of RCTs pooled for analysis. Another review included 9 RCTs and synthesized the WOMAC pain subscores and physical function subscores to compare the efficacy of PRP with control [23]. Due to the varied follow-up among studies, synthesis of the data at the latest follow-up might not reflect the changes of PRP efficacy.…”

Section: Discussionmentioning

confidence: 99%

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

et al. 2017

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BackgroundQuite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP on knee pain and physical function.MethodsPubmed, Embase, Cochrane library, and Scopus were searched for human RCTs comparing the efficacy and/or safety of PRP infiltration with other intra-articular injections. A descriptive summary and quality assessment were performed for all the studies finally included for analysis. For studies reporting outcomes concerning Western Ontario and McMaster Universities Arthritis Index (WOMAC) or adverse events, a random-effects model was used for data synthesis.ResultsFourteen RCTs comprising 1423 participants were included. The control included saline placebo, HA, ozone, and corticosteroids. The follow-up ranged from 12 weeks to 12 months. Risk of bias assessment showed that 4 studies were considered as moderate risk of bias and 10 as high risk of bias. Compared with control, PRP injections significantly reduced WOMAC pain subscores at 3, 6, and 12 months follow-up (p = 0.02, 0.004, <0.001, respectively); PRP significantly improved WOMAC physical function subscores at 3, 6, and 12 months (p = 0.002, 0.01, <0.001, respectively); PRP also significantly improved total WOMAC scores at 3, 6 and 12 months (all p < 0.001); nonetheless, PRP did not significantly increased the risk of post-injection adverse events (RR, 1.40 [95% CI, 0.80 to 2.45], I 2 = 59%, p = 0.24).ConclusionsIntra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids.Review registrationPROSPERO CRD42016045410. Registered 8 August 2016.Electronic supplementary materialThe online version of this article (doi:10.1186/s13018-017-0521-3) contains supplementary material, which is available to authorized users.

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“…A total of 145 titles and abstracts were preliminarily reviewed, and 10 published systematic reviews ultimately met the eligibility criteria (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

“…Table presents the methodological characteristics of included systematic reviews. Half of the included systematic reviews only included randomized clinical trials (RCTs), while others included RCTs and non‐RCTs. The evidence degree of each systematic review was Level II.…”

Section: Resultsmentioning

confidence: 99%

Intra‐articular platelet‐rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations

et al. 2017

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Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee

Abstract: I.

Cited by 102 publications

References 33 publications

Platelet-rich plasma injection is not more effective than hyaluronic acid to treat knee osteoarthritis when using a random-effects model

Platelet-rich plasma injection is not more effective than hyaluronic acid to treat knee osteoarthritis when using a random-effects model

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

Intra‐articular platelet‐rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations

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