“…Consequently, the patient must be informed that EN is a “mini invasive” pancreatic procedure with the advantage of preserving pancreatic parenchyma but without a reduced risk of POPF and its associated morbidity. The risk factors of overall and severe POPF have already been studied: on the one hand, several factors, such as age [ 6 ], body mass index [ 10 ], distance to the main pancreatic duct [ 17 ], history of acute pancreatitis [ 6 ], and New York Heart Association class [ 14 ], were independently identified by a single publication each (Table 1 ); on the other hand, cystic morphology [ 6 , 11 ] and tumor location [ 9 , 10 , 13 ] were identified in at least two independent series (Table 1 ). Our study confirmed that tumor location (i.e., the corresponding EN area) was relevant to predict POPF, but we improved the precision of this result by delimiting a particular zone with a higher risk than the rest of the pancreatic parenchyma.…”