Short‐term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users

Gandhi, Devang; Jaffe, Jerome H.; McNary, Scot; Kavanagh, Greg; Hayes, Michael; Currens, Marian

doi:10.1046/j.1360-0443.2003.00334.x

Cited by 60 publications

(40 citation statements)

References 30 publications

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“…As oral opioid substitution rather than opioid detoxification therapy is becoming the standard treatment of choice in most countries, most of the recent international studies include outcomes following opioid substitution therapy. [4][5][6] However, a study by Gandhi et al [8] on the short-term outcomes of a 3-day ambulatory opioid detoxification programme reported a reduction in the severity of dependence for some younger heroin users who may not yet be ready to engage in long-term abstinence-oriented or opioid substitution treatments.…”

Section: Articlementioning

confidence: 99%

Outcomes of adult heroin users v. abstinent users four years after presenting for heroin detoxification treatment

et al. 2014

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Background. There are no studies in South Africa (SA) on the outcomes following detoxification and psychosocial rehabilitation of heroin-dependent patients.Objective. To compare the demographic, clinical, forensic and treatment data of active heroin users v. users who were abstinent at the time of interview 4 years after attending the Opioid Detoxification Unit at Stikland Hospital in the Western Cape Province, SA. Method. Participants included patients above the age of 16 years who had been admitted to the Opioid Detoxification Unit at Stikland Hospital for heroin detoxification between July 2006 and June 2007. Participants were individually interviewed (either in person or telephonically) using a structured self-report questionnaire to collect demographic, clinical, forensic and treatment data 4 years following heroin detoxification treatment at this unit. Results. Of the participants, 60% were abstinent and a large portion (34%) attributed this to social support. Furthermore, there was a significant (p=0.04) difference in the longest period of abstinence between the past user group and active users, with more participants in the past user group being abstinent for 18 months or longer (n=24, 57%) than in the active users group (n=8, 29%). Active users (n=18, 64%) had significantly (p=0.03) more legal problems than abstinent users (n=14, 33%). Most participants (n=38, 54%) relapsed within 3 months after index detoxification and rehabilitation. Conclusion. Active users had more legal problems than abstinent users, with social support structures playing a pivotal role in abstinence. Future research should assess the impact of interventions such as post-discharge social support programmes on criminality and heroin use in those that relapse following treatment.

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Section: Articlementioning

confidence: 99%

Outcomes of adult heroin users v. abstinent users four years after presenting for heroin detoxification treatment

et al. 2014

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“…Breen [20] used a flexible buprenorphine reduction following transfer from three methadone dosages, and Ghandi [21] allocated to two different buprenorphine treatments.…”

Section: Study Methodsmentioning

confidence: 99%

“…The participants were mainly male (mean 64% 8 3%-11%) with a mean age of 29 ( 8 6.5-7.2) years. Years of heroin use prior to treatment was reported by three of the studies [20][21][22] ranging from 3.5 to 32 years.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Breen [20] , Raistrick [23] and Ghandi [21] reported follow-up at 1 month, and Ghandi [21] also included 3-and 6-month followup periods. Gibson [22] conducted follow-up at day 91 and Lintzeris [19] at day 35.…”

Section: Follow-up Periodsmentioning

confidence: 99%

“…Ghandi [21] randomised to either the 'standard' or 'high' dose regime and participants chose their preferred route of administration, with both sublingual tablets and intramuscular injection formulations being available. The route of administration became a major concern of the participants with most subjects having a strong preference for sublingual tablets.…”

Section: Buprenorphine Detoxification Protocolsmentioning

confidence: 99%

See 2 more Smart Citations

Post-Treatment Outcomes of Buprenorphine Detoxification in Community Settings: A Systematic Review

Horspool¹,

Seivewright²,

Armitage

et al. 2008

Eur Addict Res

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A systematic review was undertaken to examine studies of buprenorphine detoxification that has included post-treatment outcomes as well as more immediate aspects of progress. Studies were required to report details of buprenorphine withdrawal regime and post-treatment outcomes including abstinence rates. Only five studies met these criteria, with buprenorphine regimes lasting 3 days to several weeks, and with variable follow-up. Detoxification completion rates were 65–100%, but relatively few treatment completers were then drug free at their follow-up appointments. In subsequent prescribing, more patients had returned to opioid maintenance than complied with naltrexone. Our preliminary review indicates that buprenorphine is a suitable medication for the process of opiate detoxification but that this newer treatment option has not led to higher rates of abstinence following withdrawal. Further studies are required to more substantially examine abstinence outcomes, as well as characteristics which predict success.

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Buprenorphine for the management of opioid withdrawal

Gowing

Ali

White

2006

Cochrane Database of Systematic Reviews

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Short‐term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users

Cited by 60 publications

References 30 publications

Outcomes of adult heroin users v. abstinent users four years after presenting for heroin detoxification treatment

Outcomes of adult heroin users v. abstinent users four years after presenting for heroin detoxification treatment

Post-Treatment Outcomes of Buprenorphine Detoxification in Community Settings: A Systematic Review

Buprenorphine for the management of opioid withdrawal

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