Short-term oral oleoyl-estrone decreases the expression of ghrelin in the rat stomach

Ferrer-Lorente, Raquel; Fernández-López, José Antonio; Cabot, Cristina

doi:10.1016/j.regpep.2008.09.004

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Estradiol has been shown to inhibit feeding via hypothalamic actions. The reported effects of estradiol are complex and include attenuation of ghrelin's orexigenic action (Ferrer-Lorente et al, 2009 ), inhibition of neuropeptide Y (NPY)/agouti-related peptide (AgRP) orexigenic neurons (Olofsson et al, 2009 ), potentiation of cholecystokinin-induced satiety (Asarian and Geary, 2007 ), and stimulation of pro-opiomelanocortin (POMC) anorexigenic neurons (Zhu et al, 2015 ). Estradiol-induced hypophagia may also involve hypothalamic serotonergic activation (Pelletier et al, 2007 ; Silva et al, 2010 ; Rivera et al, 2012 ; Santollo et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats

et al. 2018

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Menopause-induced changes may include increased incidence of both depression/anxiety and obesity. We hypothesized that behavioral changes that may develop after ovarian failure could be related to neurochemical and metabolic aspects affected by this condition and that high-fat intake may influence these associations. The present study investigated in rats the effects of ovariectomy, either alone or combined with high-fat diets enriched with either lard or fish-oil, on metabolic, behavioral and monoaminergic statuses, and on gene expression of neuropeptides and receptors involved in energy balance and mood regulation. Female rats had their ovaries removed and received either standard chow (OvxC) or high-fat diets enriched with either lard (OvxL) or fish-oil (OvxF) for 8 weeks. The Sham group received only chow diet. Ovariectomy increased feed efficiency and body weight gain and impaired glucose homeostasis and serotonin-induced hypophagia, effects either maintained or even accentuated by the lard diet but counteracted by the fish diet. The OvxL group developed obesity and hyperleptinemia. Regarding components of hypothalamic serotonergic system, both ovariectomy alone or combined with the fish diet increased 5-HT2C expression while the lard diet reduced 5-HT1B mRNA. Ovariectomy increased the anxiety index, as derived from the elevated plus maze test, while both high-fat groups showed normalization of this index. In the forced swimming test, ovariectomy allied to high-lard diet, but not to fish-oil diet, reduced the latency to immobility, indicating vulnerability to a depressive-like state. Linear regression analysis showed hippocampal AgRP to be negatively associated with the anxiety index and hypothalamic AgRP to be positively associated with the latency to immobility. These AgRp gene expression associations are indicative of a beneficial involvement of this neuropeptide on both depression and anxiety measures. The present findings demonstrate metabolic, neurochemical and behavioral alterations after ovaries removal and highlight a positive effect of high-fat feeding on the anxiety-like behavior shown by ovariectomized animals. Since the polyunsaturated ômega-3 intake (fish diet), unlike the saturated fat intake (lard diet), failed to induce deleterious metabolic or neurochemical consequences, further studies are needed focusing on the potential of this dietary component as an adjuvant anxiolytic agent after menopause.

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Section: Introductionmentioning

confidence: 99%

High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats

et al. 2018

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“…The effects of OE on appetite are more complex than simply eliciting satiation; intracerebroventricular injection of OE dissolved in dimethylsulfoxide provokes a loss of appetite (and maintenance of energy expenditure) in rats, which demonstrates a “central” effect of OE on the brain. On the other side, OE has been found to dramatically inhibit, in the stomach, the expression of the main orexigenic gut peptide, ghrelin; this peptide is directly involved in the maintenance of feeding, and its absence decreases food intake. OE also affects negatively a number of anorexigenic peptides along the intestinal channel, but the effects are less marked than those of ghrelin.…”

Section: Oleoyl‐estrone Treatment and Energy Balance Effects On Foodmentioning

confidence: 99%

“…On the other side, OE has been found to dramatically inhibit, in the stomach, the expression of the main orexigenic gut peptide, ghrelin; this peptide is directly involved in the maintenance of feeding, and its absence decreases food intake. OE also affects negatively a number of anorexigenic peptides along the intestinal channel, but the effects are less marked than those of ghrelin. Since OE is largely taken up by the stomach, the fast satiating effects of OE are probably conveyed through modulation of ghrelin synthesis and release.…”

Section: Oleoyl‐estrone Treatment and Energy Balance Effects On Foodmentioning

confidence: 99%

Oleoyl‐Estrone

Remesar

Fernández-López

Alemany

2011

Medicinal Research Reviews

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Oleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis). The energy gap is fulfilled with adipose tissue fat, sparing body protein and maintaining glycemia (and glycogen) with lower insulin and leptin levels. OE (in fact W) acts through specific receptors, different from those of estrogen. OE increases cholesterol catabolism, reducing hypercholesterolemia in obese rats. The main metabolic effect on adipose tissue is lowering of lipid synthesis, maintaining unchanged the intracellular lipolytic processes; the imbalance favors the progressive loss of fat, which is largely used by the muscle. OE administration induces additive effects with other antiobesity agents, such as β(3)-adrenergic agonists, forcing a massive loss of lipid. Corticosteroids markedly limit OE action by altering the liver control of lipogenesis. OE also inhibits the action of 17β-hydroxysteroid dehydrogenase, decreasing the synthesis of β-estradiol and testosterone. Discontinuous treatment allows for maximal efficacy both in rats and humans. OE has the advantage that the loss of fat is maintained and does not require additional dietary limitations.

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“…The orexigenic potency of ghrelin is sexually differentiated and negatively modulated by estrogens [69], which also decrease its expression in rat stomach [110]. While one study documented that estrogens were without effect on circulating ghrelin levels in normally cycling and postmenopausal women [79], another noted that estrogen replacement therapy increased them in postmenopausal women [178].…”

Section: Introductionmentioning

confidence: 99%

Estradiol signaling in the regulation of reproduction and energy balance

Sinchak

Wagner

2012

Frontiers in Neuroendocrinology

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Our knowledge of membrane estradiol signaling mechanisms and their interactions that regulate physiology and behavior has grown rapidly over the past three decades. The discovery of novel membrane estrogen receptors and their signaling mechanisms has started to reveal the complex timing and interactions of these various signaling mechanisms with classical genomic steroid actions within the nervous system to regulate physiology and behavior. The activation of the various estrogenic signaling mechanisms is site specific and differs across the estrous cycle acting through both classical genomic mechanisms and rapid membrane-initiated signaling to coordinate reproductive behavior and physiology. This review focuses on our current understanding of estrogenic signaling mechanisms to promote: 1) sexual receptivity within the arcuate nucleus of the hypothalamus, 2) estrogen positive feedback that stimulates de novo neuroprogesterone synthesis to trigger the luteinizing hormone surge important for ovulation and estrous cyclicity, and 3) alterations in energy balance.

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Short-term oral oleoyl-estrone decreases the expression of ghrelin in the rat stomach

Cited by 5 publications

References 25 publications

High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats

High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats

Oleoyl‐Estrone

Estradiol signaling in the regulation of reproduction and energy balance

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