Short-term oral exposure to low doses of nano-sized TiO 2 and potential modulatory effects on intestinal cells

Ammendolia, Maria Grazia; Iosi, Francesca; Maranghi, Francesca; Tassinari, Roberta; Cubadda, Francesco; Aureli, Federica; Raggi, Andrea; Superti, Fabiana; Mantovani, Alberto; Berardis, Barbara De

doi:10.1016/j.fct.2017.01.031

Cited by 62 publications

(58 citation statements)

References 48 publications

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“…In the current study, the group of rats intoxicated with TiO 2 NPs showed significant increased of LPO, AST and ALT and decreased the total antioxidant compared to the treated and control group. Many authors reported that TiO 2 NPs increased the oxidative stress indices and liver enzyme markers [4] , [6] , [16] .…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats

Hassanein

El-Amir

2018

International Journal of Veterinary Science and Medicine

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Section: Discussionmentioning

confidence: 99%

“…Nanoparticles induced cytotoxicity, apoptosis and oxidative stress to the liver cells [5] , [6] . TiO 2 NPs were observed in the hepatocytes and Kupffer cells in mice [5] .…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats

Hassanein

El-Amir

2018

International Journal of Veterinary Science and Medicine

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“…These studies generally show alterations in cell viability induced by metal based ENM, with high cytotoxicity induced by ZnO [ 39 – 43 ], SiO 2 [ 17 , 44 , 45 ], and Ag ENM [ 46 ]. Milder cytotoxic effects have been reported for Au [ 47 – 49 ], TiO 2 ENM [ 15 , 32 , 33 , 40 , 48 , 50 – 56 ], and carbon nanotubes [ 37 , 51 , 57 , 58 ] in short-term studies.…”

Section: Interaction Of Ingested Enm With the Gitmentioning

confidence: 99%

“… No significant cytotoxic effect of TiO 2 -NPs was observed in LDH and MTT assays at all concentrations after 6, 24, and 48 h exposure. Ammendolia et al 2017 [ 50 ] Caco-2 cells human colorectal adenocarcinoma cells, CFE colony forming efficiency, COOH- SW-CNTs carboxylic acid functionalized single walled carbon nanotubes, CTAB cetyltrimethylammonium bromide, DLS dynamic light scattering, DS digestion simulated, EC 50 half maximal effective concentration, HT-29 human colon carcinoma cells, HT29-MTX human adenocarcinoma mucus secreting cells, IC inhibition concentration, LD50 Lethal dose, LoVo human colon carcinoma cell line, MUTZ-3 human dendritic cells, MW-CNTs multi-walled carbon nanotubes, PAA polyacrylic acid, PAH polyelectrolyte poly(allylamine) hydrochloride, PEG poly-ethylene glycol, PEG-SW-CNTs poly(ethylene glycol) functionalized single walled carbon nanotubes, Raji B line human Burkitt’s lymphoma cells, RKO human colon adenocarcinoma cells, SW- CNTs single walled- carbon nanotubes, SW480 human colon adenocarcinoma cells, T84 human colonic epithelial cells, TEM transmission electron microscopy, THP-1 Human macrophages …”

Section: Interaction Of Ingested Enm With the Gitmentioning

confidence: 99%

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

et al. 2017

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Background: There is a fundamental gap of knowledge on the health effects caused by the interaction of engineered nanomaterials (ENM) with the gastro-intestinal tract (GIT). This is partly due to the incomplete knowledge of the complex physical and chemical transformations that ENM undergo in the GIT, and partly to the widespread belief that GIT health effects of ENM are much less relevant than pulmonary effects. However, recent experimental findings, considering the role of new players in gut physiology (e.g. the microbiota), shed light on several outcomes of the interaction ENM/GIT. Along with this new information, there is growing direct and indirect evidence that not only ingested ENM, but also inhaled ENM may impact on the GIT. This fact, which may have relevant implications in occupational setting, has never been taken into consideration. This review paper summarizes the opinions and findings of a multidisciplinary team of experts, focusing on two main aspects of the issue: 1) ENM interactions within the GIT and their possible consequences, and 2) relevance of gastro-intestinal effects of inhaled ENMs. Under point 1, we analyzed how luminal gut-constituents, including mucus, may influence the adherence of ENM to cell surfaces in a size-dependent manner, and how intestinal permeability may be affected by different physico-chemical characteristics of ENM. Cytotoxic, oxidative, genotoxic and inflammatory effects on different GIT cells, as well as effects on microbiota, are also discussed. Concerning point 2, recent studies highlight the relevance of gastro-intestinal handling of inhaled ENM, showing significant excretion with feces of inhaled ENM and supporting the hypothesis that GIT should be considered an important target of extrapulmonary effects of inhaled ENM. Conclusions:In spite of recent insights on the relevance of the GIT as a target for toxic effects of nanoparticles, there is still a major gap in knowledge regarding the impact of the direct versus indirect oral exposure. This fact probably applies also to larger particles and dictates careful consideration in workers, who carry the highest risk of exposure to particulate matter.

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“…A sex-specific effect on villus cells proliferation was observed in male rats, indicating a potential role for the endocrine system in this process. Oxidative stress in intestinal cells was transient and decreased after 24 h [162] .…”

Section: Inorganic Filtersmentioning

confidence: 98%

Neurotoxic effect of active ingredients in sunscreen products, a contemporary review

et al. 2017

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Sunscreen application is the main strategy used to prevent the maladies inflicted by ultraviolet (UV) radiation. Despite the continuously increasing frequency of sunscreen use worldwide, the prevalence of certain sun exposure-related pathologies, mainly malignant melanoma, is also on the rise. In the past century, a variety of protective agents against UV exposure have been developed. Physical filters scatter and reflect UV rays and chemical filters absorb those rays. Alongside the evidence for increasing levels of these agents in the environment, which leads to indirect exposure of wildlife and humans, recent studies suggest a toxicological nature for some of these agents. Reviews on the role of these agents in developmental and endocrine impairments (both pathology and related mechanisms) are based on both animal and human studies, yet information regarding the potential neurotoxicity of these agents is scant. In this review, data regarding the neurotoxicity of several organic filters: octyl methoxycinnamate, benzophenone-3 and −4, 4-methylbenzylidene camphor, 3-benzylidene camphor and octocrylene, and two allowed inorganic filters: zinc oxide and titanium dioxide, is presented and discussed. Taken together, this review advocates revisiting the current safety and regulation of specific sunscreens and investing in alternative UV protection technologies.

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Short-term oral exposure to low doses of nano-sized TiO 2 and potential modulatory effects on intestinal cells

Cited by 62 publications

References 48 publications

Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats

Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

Neurotoxic effect of active ingredients in sunscreen products, a contemporary review

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