Short-term laryngeal electromyography and histopathological findings after primary reconstruction of the inferior laryngeal nerve in rabbits: prospective study

Dalğıç, Abdullah; Kandogan, T; Koç, Murat; Kulan, Can Ahmet; Yağcı, Ayşe; Engin, Ömer; Aksoy, Gürsoy; Ozuer, M Ziya

doi:10.1017/s0022215112002381

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…Spontaneous laryngeal reinnervation is possible in lesions that affect the laryngeal nerve, even chronically, at least in animal models [15,16]. This can occur at the expense of a healthy residual nerve or adjacent nerves [17]. However, this regeneration is often incomplete and time dependent [18].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Paralysis Recovered Two Years After a Head Trauma by Growth Hormone Treatment and Neurorehabilitation

Guerra¹,

Lema²,

Agra³

et al. 2021

Preprint

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The aim of this study is to describe the cognitive and speech results obtained after growth hormone (GH) treatment and neurorehabilitation in a man that suffered a traumatic brain injury (TBI). 17 months after the accident, the patient was treated with growth hormone (GH), together with neurostimulation and speech therapy. At admission, the left vocal cord revealed paralyzed, in the paramedian position, a situation compatible with a recurrent nerve injury. Clinical and rehabilitation assessments revealed a prompt improvement in speech and cognitive functions, and following completion of treatment, endoscopic examination showed recovery of vocal cord mobility. These results, together with previous results from our group, indicate that GH treatment is safe and effective for helping neurorehabilitation in chronic speech impairment due to central laryngeal paralysis, as well as impaired cognitive functions.

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Section: Discussionmentioning

confidence: 99%

Laryngeal Paralysis Recovered Two Years After a Head Trauma by Growth Hormone Treatment and Neurorehabilitation

Guerra¹,

Lema²,

Agra³

et al. 2021

Preprint

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“…Although CT, MRI, and FNAC may be somewhat helpful in distinguishing schwannomas from other tumors, 5 postoperative histopathologic examination is still the gold standard, with the presence of a clear capsule, Antoni A and/or B areas, and a positive reaction for S-100 protein considered characteristic histopathological features of schwannomas. 7 The Antoni A region can be described as a densely packed pattern of spindle cells, with frequent nuclear palisading arrangements, whereas the Antoni B region consists of loosely arranged spindle cells, with vacuoles and spindle-shaped nuclei prone to degeneration, hemorrhage, and cyst formation. 5 In both patterns, the tumor cytoplasm is elongated and the nuclei are regular and oval.…”

Section: Discussionmentioning

confidence: 99%

Extracranial non-vestibular head and neck schwannomas

Wang

Yuan

Chen

et al. 2015

SMJ

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Objectives:To retrospectively describe our 10-year experience with extracranial non-vestibular head and neck schwannomas by presenting their clinical features, diagnostic methods, surgical decisions, and treatment outcomes.Methods:This is a retrospective study conducted at the Department of Otolaryngology, Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Shanghai First People’s Hospital, Shanghai, China. The medical records of 46 patients diagnosed with schwannoma in the extracranial head and neck region as confirmed on paraffin-embedded sections from January 2003 to December 2012 were reviewed.Results:All tumors were benign, and 52% presented as asymptomatic palpable solitary masses. Compressive symptoms, which can represent meaningful indicators of the nerve of origin were commonly noted. The most common nerve of origin was the brachial plexus (n=13, 28.3%).Conclusion:While postoperative histopathologic examination is still the gold standard, fine needle aspiration cytology, CT scan, and magnetic resonance imaging may be useful in the diagnosis of schwannomas. As schwannomas are radioresistant, and as, despite their benign nature, can cause severe secondary symptoms, the best treatment of choice is complete excision with preservation of functions.

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“…In humans, the spontaneous regeneration of the RLN remains a controversial subject ( 7 , 60 , 65 ). Spontaneous laryngeal reinnervation may occur through regeneration of a healthy residual RLN or from nerves in the surrounding area ( 3 ). Strategies to promote sufficient reinnervation of the PCA muscle may improve the effectiveness of spontaneous recovery following RLN injury.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral nerves enable communication between the brain and muscles, skin and organs, and peripheral nerve injury often results in the loss of sensory or motor function ( 1 , 2 ). The majority of the functions of the larynx depend on healthy vocal fold motion, which in turn relies on an intact recurrent laryngeal nerve (RLN) ( 3 ). Laryngeal palsy often occurs as a result of recurrent laryngeal or vagal nerve injury during oncological surgery of the head and neck ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Neurotrophin expression and laryngeal muscle pathophysiology following recurrent laryngeal nerve transection

Wang

Yuan

et al. 2015

Molecular Medicine Reports

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Laryngeal palsy often occurs as a result of recurrent laryngeal or vagal nerve injury during oncological surgery of the head and neck, affecting quality of life and increasing economic burden. Reinnervation following recurrent laryngeal nerve (RLN) injury is difficult despite development of techniques, such as neural anastomosis, nerve grafting and creation of a laryngeal muscle pedicle. In the present study, due to the limited availability of human nerve tissue for research, a rat model was used to investigate neurotrophin expression and laryngeal muscle pathophysiology in RLN injury. Twenty-five male Sprague-Dawley rats underwent right RLN transection with the excision of a 5-mm segment. Vocal fold movements, vocalization, histology and immunostaining were evaluated at different time-points (3, 6, 10 and 16 weeks). Although vocalization was restored, movement of the vocal fold failed to return to normal levels following RLN injury. The expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor differed in the thyroarytenoid (TA) and posterior cricoarytenoid muscles. The number of axons did not increase to baseline levels over time. Furthermore, normal muscle function was unlikely with spontaneous reinnervation. During regeneration following RLN injury, differences in the expression levels of neurotrophic factors may have resulted in preferential reinnervation of the TA muscles. Data from the present study indicated that neurotrophic factors may be applied for restoring the function of the laryngeal nerve following recurrent injury.

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Short-term laryngeal electromyography and histopathological findings after primary reconstruction of the inferior laryngeal nerve in rabbits: prospective study

Cited by 7 publications

References 25 publications

Laryngeal Paralysis Recovered Two Years After a Head Trauma by Growth Hormone Treatment and Neurorehabilitation

Laryngeal Paralysis Recovered Two Years After a Head Trauma by Growth Hormone Treatment and Neurorehabilitation

Extracranial non-vestibular head and neck schwannomas

Neurotrophin expression and laryngeal muscle pathophysiology following recurrent laryngeal nerve transection

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