“…The necessity of a surgical intervention has also been the general thinking in the era of antibiotics [4,57]. We consider that the need for surgery varies.…”
Section: Surgery Versus Antimicrobials Onlymentioning
confidence: 99%
“…As shown in Table 2, the duration of i.v. administration has shortened elsewhere as well [57][58][59]. Serum antimicrobial assays before switch to the oral route were once recommended [54] A c c e p t e d M a n u s c r i p t 13 are no longer used.…”
Section: Intravenous Versus Oral Administrationmentioning
“…The necessity of a surgical intervention has also been the general thinking in the era of antibiotics [4,57]. We consider that the need for surgery varies.…”
Section: Surgery Versus Antimicrobials Onlymentioning
confidence: 99%
“…As shown in Table 2, the duration of i.v. administration has shortened elsewhere as well [57][58][59]. Serum antimicrobial assays before switch to the oral route were once recommended [54] A c c e p t e d M a n u s c r i p t 13 are no longer used.…”
Section: Intravenous Versus Oral Administrationmentioning
“…Duration of treatment regimens in children with uncomplicated disease is falling. 7,8 For both conditions, failure to respond within 48-72 hours of onset of appropriate antibiotic therapy should prompt re-evaluation for a surgical focus using appropriate scans. If the patient remains systemically unwell, the possibility of additional foci, including a distant focus such as endocarditis, must also be considered.…”
Section: Acute Septic Arthritis and Osteomyelitismentioning
“…1,[3][4][5][6]8 A detailed description of the search is shown in Fig 1. The studies included in this review are listed in Table 1 and the details of the treatment, bacteriology, antibiotics used, and outcomes are shown in Table 2.…”
Section: Resultsmentioning
confidence: 99%
“…The largest study was conducted by Zaoutis et al with data collection for 1969 subjects, 1 whereas Jaberi et al's study had the smallest cohort of only 12 patients. 8 Additionally the location and actual year(s) of data of collection are varied. The largest prospective study, by Peltola et al, 3 collected patients over 22 years ( Table 1).…”
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