Short-Term Intravenous Antibiotic Treatment of Acute Hematogenous Bone and Joint Infection in Children: A Prospective Randomized Trial

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

“…The necessity of a surgical intervention has also been the general thinking in the era of antibiotics [4,57]. We consider that the need for surgery varies.…”

“…As shown in Table 2, the duration of i.v. administration has shortened elsewhere as well [57][58][59]. Serum antimicrobial assays before switch to the oral route were once recommended [54] A c c e p t e d M a n u s c r i p t 13 are no longer used.…”

Bone and joint infection

“…Duration of treatment regimens in children with uncomplicated disease is falling. 7,8 For both conditions, failure to respond within 48-72 hours of onset of appropriate antibiotic therapy should prompt re-evaluation for a surgical focus using appropriate scans. If the patient remains systemically unwell, the possibility of additional foci, including a distant focus such as endocarditis, must also be considered.…”

Route and Length of Therapy of Acute Uncomplicated Hematogenous Osteomyelitis: Do We Have the Answers Yet?

“…1,[3][4][5][6]8 A detailed description of the search is shown in Fig 1. The studies included in this review are listed in Table 1 and the details of the treatment, bacteriology, antibiotics used, and outcomes are shown in Table 2.…”

“…The largest study was conducted by Zaoutis et al with data collection for 1969 subjects, 1 whereas Jaberi et al's study had the smallest cohort of only 12 patients. 8 Additionally the location and actual year(s) of data of collection are varied. The largest prospective study, by Peltola et al, 3 collected patients over 22 years ( Table 1).…”