Short-term intensive training attenuates the exercise-induced interaction of mono-1/2 cells and platelets after coronary bypass in cardiac patients

Abstract

The interaction between platelets and monocytes plays a critical role in the pathogenesis and progression of cardiovascular diseases. This study investigated how short-term intensive training (SIT) influences monocyte subset characteristics and exercise-induced monocyte and platelet aggregates (MPAs) following elective coronary bypass (CABG) in cardiac patients. Forty-nine patients hospitalised for CABG were randomised into SIT (N=26) and conventional training (CT, N=23) groups. The SIT subjects underwent supervised aerobic training at 80~120 % of the ventilatory anaerobic threshold based on sub-maximal exercise tests performed 7 days post-CABG for 20 sessions with two sessions/day and 30 min/session, which were completed within four weeks after surgery. The CT subjects performed light-intensity conditioning exercise for ≤4 sessions. Resting and maximal exercise-mediated monocyte characteristics and MPA were determined before and following intervention. The SIT group had a larger improvement in ventilation efficiency and anaerobic threshold than the CT group; the SIT group exhibited larger reductions in blood monocyte subtypes 1 and 2 (Mono1 and 2) counts at rest than the CT group; the SIT group but not the CT group exhibited attenuated formation of Mono1/platelet hetero-aggregation (MPA1) and CD42b expression on Mono1/2 caused by strenuous exercise; and plasma levels of macrophage inflammatory protein-1β and soluble P-selectin showed similar trends as Mono1/2 and MPA1, respectively. In conclusion, SIT modestly improved aerobic capacity in patients following CABG. Moreover, SIT simultaneously ameliorated the CD42b expression of Mono1/2 cells and maximal exercise-induced MPA1, which may reduce the risk of inflammatory thrombosis.

Platelet–Leucocyte Aggregates as Novel Biomarkers in Cardiovascular Diseases

“…Identifying vulnerable patients before the operation might allow designing suitable interventions to reduce the additional risk. A certain type of exercise regime reduced PLA-M in post-CABG patients [ 101 ]. It remains an interesting question as to whether similar actions before cardiac surgery would effectively decrease the risk of AKI.…”

Fit, Female or Fifty–Is Cardiac Rehabilitation “Fit” for Purpose for All? A Systematic Review and Meta-Analysis With Meta-Regression

“…A further 96 articles were excluded due to lack of exercise prescription, no cardiac event, having only Phase I CR, no outcome measures to assess change in cardiorespiratory status, or were protocols or review articles. Thus 42 articles were available for quantitative analysis, of which 13 were randomized controlled trials ( 33 , 35 , 36 , 40 , 41 , 44 , 45 , 47 , 48 , 52 , 54 , 63 , 65 ) and 29 were cohort studies ( 26 – 32 , 34 , 37 – 39 , 42 , 43 , 46 , 49 – 51 , 53 , 55 – 62 , 64 , 66 , 67 ). Included papers are shown in Table 1 , together with study results and the level of evidence of the study.…”

Stepper-Based Training Improves Monocyte–Platelet Aggregation and Thrombin Generation in Nonambulatory Hemiplegic Patients

“…Monocytes were selected by gating forward versus side scatter and side scatter versus CD14 expression. In the present study, monocytes were divided into three subsets by surface expression of CD14 (lipopolysaccharide receptor), CD16 (Fc receptor III), and CCR2 (monocyte chemoattractant protein-1 receptor) as classical (CD14 ++ CD16 − CCR2 + , Mono 1), intermediate (CD14 ++ CD16 + CCR2 + , Mono 2), and nonclassical (CD14 + CD16 + CCR2 − , Mono 3) subsets (11,23). Counts of monocyte subsets (in cells per microliter) were obtained from the subset cell percentages in the plot region of R1 and R2 gating by multiplying the absolute monocyte count in the complete blood count (XS-800i; Sysmex, Norderstedt, Germany).…”