Short-Term Improvement in Physical Activity and Body Composition After Supervised Exercise Training Program in Idiopathic Pulmonary Fibrosis

Vainshelboim, Baruch; Fox, Benjamin D.; Kramer, Mordechai R.; Izhakian, Shimon; Gershman, Evgeni; Oliveira, José

doi:10.1016/j.apmr.2016.01.018

Cited by 33 publications

(57 citation statements)

References 48 publications

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“…An additional strength of the study is that PA levels were reported using one-on-one personalized interviews rather than self-filling questionnaires, which probably increased the accuracy of the self-reported PA. Moreover, IPAQ is accepted as a reliable and validated tool for the assessment of PA in many research and clinical settings [22,23,24,52], and recently was also studied in IPF subjects [53,54]. …”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Exertional Desaturation Are Associated with Mortality in Idiopathic Pulmonary Fibrosis

Vainshelboim

Kramer

Izhakian

et al. 2016

JCM

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Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that manifests in hypoxemia, inactivity, and poor prognosis. This study aimed to assess the prognostic role of physical activity (PA) and exertional desaturation (ED) with mortality in IPF. At baseline, 34 IPF patients (68 (50–81) years) were interviewed using the International Physical Activity Questionnaire (IPAQ), and SpO2 was assessed pre to post 6-min walking test (∆SpO2). Patients were prospectively followed up for 40 months. Receiver operating characteristics curve analysis determined cut-off points associated with mortality, and Cox proportional hazard ratio (HR) were conducted. Thresholds for increased mortality risk in IPF patients were determined as IPAQ ≤ 417 metabolic equivalent task (METS)-min/week, p = 0.004 (HR; 9.7, CI 95% (1.3–71.9), p = 0.027), and ∆SpO2 ≥ 10%, p = 0.002, (HR; 23.3, CI 95% (1.5–365), p = 0.025). This study demonstrated a significant association of PA and ED with mortality in IPF patients. The findings emphasize the clinical importance of PA and ED assessments to aid in IPF risk stratification, prognosis prediction, and in providing early appropriate treatments, such as pulmonary rehabilitation, PA consultation, oxygen supplementation, and lung transplantation referral. These results underscore that even low levels of PA corresponding to 100–105 min/week were associated with a reduced mortality risk and better survival in IPF.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Exertional Desaturation Are Associated with Mortality in Idiopathic Pulmonary Fibrosis

Vainshelboim

Kramer

Izhakian

et al. 2016

JCM

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“…The strengths of the current study include: the prospective collection of the data, using an established physical activity questionnaire (IPAQ) [22][23][24]55], which has been previously utilized among patients with IPF [36,56]. An additional strength of the study is that sitting and walking times were collected using an in-person interview, a method that possibly overcomes some self-report bias.…”

Section: Discussionmentioning

confidence: 99%

“…Body fat percentage was assessed using Lange skin-fold caliper (Beta technology, Santra Cruz, CA, USA) on 4 anatomical sites (biceps, triceps, suprailiac, and subscapular) as previously proposed and validated by Durnin and Womersley [35]. A detailed description of these procedures can be found in our previous reports [18,20,36].…”

Section: Pulmonary Function Cardiopulmonary Exercise Testing 6mwd mentioning

confidence: 99%

Lifestyle Behaviors and Clinical Outcomes in Idiopathic Pulmonary Fibrosis

et al. 2017

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Background: Lifestyle behaviors are not well-characterized in idiopathic pulmonary fibrosis (IPF). Objectives: To assess the association between lifestyle behaviors and clinical outcomes in patients with IPF. Methods: A total of 34 IPF patients (median age 68 years) were assessed for daily sitting and weekly walking times using the International Physical Activity Questionnaire by in-person interview at baseline, and they were followed up for up to 40 months. Cox proportional hazard analysis was conducted for cardiorespiratory-related hospitalizations and mortality as outcomes. Results: Fifty percent of all patients were hospitalized, and 32% died during the follow-up period. Sitting and walking times were associated with hospitalizations and mortality in IPF. Compared to patients who reported a sitting time of <5 h/day, patients who sat 5 to <10 and ≥10 h/day experienced an increased risk of 2.4 and 5.8 (p trend = 0.036) for hospitalization and of 4.6 and 21.2 (p trend = 0.018) for mortality, respectively. Compared to patients walking <100 min/week, patients with a walking time of 100 to <150 and ≥150 min/week were associated with a 49 and 74% reduced risk for hospitalizations (p trend = 0.022) and a 62 and 86% reduced risk for mortality (p trend = 0.018), respectively. The risk for mortality was further reduced with a combination of shorter sitting and extended walking times. Conclusions: Shorter daily sitting and longer weekly walking times were associated with reduced hospitalization and mortality risks in patients with IPF. These findings suggest a clinical importance of assessing lifestyle behaviors in a comprehensive evaluation and prognostication of IPF patients. The results underscore potential clinical benefits of reducing sedentary behaviors among IPF patients; however, this warrants further investigation.

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“…The update of treatment guidelines of 2015 does not pertain to pulmonary rehabilitation of IPF patients [75]. However, a majority of randomised trials were published after 2011 [311][312][313][314]317]. Currently, the amount and quality of evidence should be considered sufficient to recommend pulmonary rehabilitation in IPF patients as an important component of treatment.…”

Section: Commentarymentioning

confidence: 99%

“…It is aimed at improving the patients' physical and mental fitness and long-term compliance with the aforementioned behaviours [303]. The beneficial effect of rehabilitation in IPF patients has been documented in many prospective, non-randomised observational studies [304][305][306][307][308][309][310] and numerous randomised trials [311][312][313][314][315][316][317][318]. A 2014 meta-analysis of 5 randomised studies (86 patients with ILDs, including IPF, undergoing rehabilitation and 82 non-rehabilitated patients comprising the control group) confirmed the beneficial effects of rehabilitation on distance in the 6MWT, peak oxygen uptake, dyspnoea severity and quality of life, with lack of adverse effects [319].…”

Section: Introductionmentioning

confidence: 99%

Guidelines of the Polish Respiratory Society for Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis

Piotrowski

Bestry²,

Białas

et al. 2020

Advances in Respiratory Medicine

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Short-Term Improvement in Physical Activity and Body Composition After Supervised Exercise Training Program in Idiopathic Pulmonary Fibrosis

Cited by 33 publications

References 48 publications

Physical Activity and Exertional Desaturation Are Associated with Mortality in Idiopathic Pulmonary Fibrosis

Physical Activity and Exertional Desaturation Are Associated with Mortality in Idiopathic Pulmonary Fibrosis

Lifestyle Behaviors and Clinical Outcomes in Idiopathic Pulmonary Fibrosis

Guidelines of the Polish Respiratory Society for Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis

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