Short-term immobilization influences use-dependent cortical plasticity and fine motor performance

Opie, George M.; Evans, Alexandra E.; Ridding, Michael C.; Semmler, John G.

doi:10.1016/j.neuroscience.2016.06.002

Cited by 21 publications

(21 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggested disruptions in the process of proprioceptive cues correcting the movement online. This is in line with recent studies (Huber et al, 2006;Weibull et al, 2011;Ngomo et al, 2012;Rosenkranz et al, 2014;Opie et al, 2016), which found a decrease in excitability in the somatosensory areas representing the previously immobilized arm: The proprioceptive cues were less processed, as well as the tactile cues (i.e., decrease of tactile discrimination; Weibull et al, 2011). Therefore, immobilized participants would take more time to correct their movement to precisely reach the target, as the processing of proprioceptive cues might be altered.…”

Section: Discussionsupporting

confidence: 90%

Short-Term Sensorimotor Deprivation Impacts Feedforward and Feedback Processes of Motor Control

Meugnot¹,

Casiez²,

Toussaint³

2020

Front. Neurosci.

View full text Add to dashboard Cite

Sensory loss involves irreversible behavioral and neural changes. Paradigms of short-term limb immobilization mimic deprivation of proprioceptive inputs and motor commands, which occur after the loss of limb use. While several studies have shown that short-term immobilization induced motor control impairments, the origin of such modifications is an open question. A Fitts' pointing task was conducted, and kinematic analyses were performed to assess whether the feedforward and/or feedback processes of motor control were impacted. The Fitts' pointing task specifically required dealing with spatial and temporal aspects (speed-accuracy trade-off) to be as fast and as accurate as possible. Forty trials were performed on two consecutive days by Control and Immobilized participants who wore a splint on the right arm during this 24 h period. The immobilization modified the motor control in a way that the full spatiotemporal structure of the pointing movements differed: A global slowdown appeared. The acceleration and deceleration phases were both longer, suggesting that immobilization impacted both the early impulse phase based on sensorimotor expectations and the later online correction phase based on feedback use. First, the feedforward control may have been less efficient, probably because the internal model of the immobilized limb would have been incorrectly updated relative to internal and environmental constraints. Second, immobilized participants may have taken more time to correct their movements and precisely reach the target, as the processing of proprioceptive feedback might have been altered.

show abstract

Section: Discussionsupporting

confidence: 90%

Short-Term Sensorimotor Deprivation Impacts Feedforward and Feedback Processes of Motor Control

Meugnot¹,

Casiez²,

Toussaint³

2020

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…However, the effects of immobilization on sensorimotor learning have not been well studied in humans. To our knowledge, only one study has examined sensorimotor learning after short-term arm immobilization (Opie et al, 2016) and did not show a clear effect of immobilization on sensorimotor learning. The lack of effect could be due, in part, to the high number of individuals with the BDNF Val66Met polymorphism that is associated with reduced use-dependent plasticity in sensorimotor areas (Kleim et al, 2006).…”

Section: Strategies To Modulate Sensorimotor Integration and Potentiamentioning

confidence: 96%

Putting the “Sensory” Into Sensorimotor Control: The Role of Sensorimotor Integration in Goal-Directed Hand Movements After Stroke

Edwards

King

Buetefisch

et al. 2019

Front. Integr. Neurosci.

View full text Add to dashboard Cite

Integration of sensory and motor information is one-step, among others, that underlies the successful production of goal-directed hand movements necessary for interacting with our environment. Disruption of sensorimotor integration is prevalent in many neurologic disorders, including stroke. In most stroke survivors, persistent paresis of the hand reduces function and overall quality of life. Current rehabilitative methods are based on neuroplastic principles to promote motor learning that focuses on regaining motor function lost due to paresis, but the sensory contributions to motor control and learning are often overlooked and currently understudied. There is a need to evaluate and understand the contribution of both sensory and motor function in the rehabilitation of skilled hand movements after stroke. Here, we will highlight the importance of integration of sensory and motor information to produce skilled hand movements in healthy individuals and individuals after stroke. We will then discuss how compromised sensorimotor integration influences relearning of skilled hand movements after stroke. Finally, we will propose an approach to target sensorimotor integration through manipulation of sensory input and motor output that may have therapeutic implications.

show abstract

“…Participants performed a ballistic thumb abduction training task (Muellbacher et al 2001) that required the abduction of their left (non-dominant) thumb with maximal acceleration [21][22][23].…”

Section: Behavioural Taskmentioning

confidence: 99%

Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation

2019

View full text Add to dashboard Cite

Background: The primary motor cortex (M1) has a vital role to play in the learning of novel motor skills. However, the physiological changes underpinning this learning, particularly in terms of dynamic changes during movement preparation, are incompletely understood. In particular, a substantial decrease in resting gamma-amino butyric acid (GABA) activity, i.e. a release of resting inhibition, is seen within M1 as a subject prepares to move. Although there is evidence that a decrease in resting inhibition occurs within M1 during motor learning it is not known whether the pre-movement "release" of GABAergic inhibition is modulated during skill acquisition. Objective: Here, we investigated changes in pre-movement GABAergic inhibitory "release" during training on a motor skill task. Methods: We studied GABAA activity using paired-pulse TMS (Short-Interval Intracortical Inhibition (SICI)) during training on a ballistic thumb abduction task, both at rest and at two time-points during movement preparation. Results: Improvement in task performance was related to a later, steeper, release of inhibition during the movement preparation phase. Specifically, subjects who showed greater improvement in the task in the early stages of training showed a reduced level of GABAergic release immediately prior to movement compared with those who improved less. Later in training, subjects who performed better showed a reduction in GABAergic release early in movement preparation. Conclusions: These findings suggest that motor training is associated with maintained inhibition in motor cortex during movement preparation.

show abstract

Short-term immobilization influences use-dependent cortical plasticity and fine motor performance

Cited by 21 publications

References 65 publications

Short-Term Sensorimotor Deprivation Impacts Feedforward and Feedback Processes of Motor Control

Short-Term Sensorimotor Deprivation Impacts Feedforward and Feedback Processes of Motor Control

Putting the “Sensory” Into Sensorimotor Control: The Role of Sensorimotor Integration in Goal-Directed Hand Movements After Stroke

Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation

Contact Info

Product

Resources

About