Short-term hyperprolactinemia decreases allergic inflammatory response of the lungs

Abstract

Hyperprolactinemia induced before antigenic challenge decreased allergic lung inflammation. These data suggest that prolactin may play a role in the pathophysiology of asthma. The present study demonstrates a prospective beneficial side effect of domperidone for asthmatic patients.

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

“…One week later (day 7), rats were boosted subcutaneously with another OVA dose. For the challenge with OVA aerosol (1% w/v in PBS), animals were individually placed in an inhalation chamber connected to an ultrasonic nebulizer for 15 min per day for 3 consecutive days (days 15, 16, and 17) according to previous studies [4, 13, 33]. …”

“…Domperidone was administered at a dose of 1.7 mg × kg– – (i.p.) 3 times per day (6: 30 a.m., 2: 00 p.m., and 9: 00 p.m., therefore a total of 5.1 mg × kg –1 per day) for 5 consecutive days from the 10th to 14th day after OVA immunization [13, 37, 38]. This treatment protocol has effectively produced stable hyperprolactinemia for more than 30 days [13, 39].…”

“…During the immune response, prolactin stimulates T cells, B cells, natural killer cells, macrophages, neutrophils, CD34-hematopoietic cells, and antigen-presenting dendritic cells [11, 12]. Previously, our group has demonstrated that both domperidone-induced and lactation hyperprolactinemia are capable of attenuating allergic lung inflammation in rats [13, 14] by decreasing leukocyte counts in bronchoalveolar lavage, reducing mucus production, and increasing the expression of IL-4, IL-6, IL-10, TNF-α, and IFN-γ in the lungs [15]. …”

Serum estradiol concentration, estradiol-toprogesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients

“…Prolactin is a peptide hormone secreted from pituitary gland which acts as a cytokine on regulatory T-cells (that express the PRL receptor constitutively) (32). The recent study by Ochoa-Amaya et al (33) proved that hyperprolactinemia induced before antigen challenge in rats, decreased allergic lung inflammation, suggesting that prolactin may act as immunomodulator in asthma. This is consistent with findings of other authors who reported that prolactin promotes Th1-type of cellular response (32,34).…”

<b>Influência do LPS e do zinco na interação mãe e filhote</b>

“…Nas fêmeas lactantes observou-se atenuação da temperatura quando comparada a daquelas virgens. Foi proposto que a presença de altos níveis de prolactina nas ratas lactantes estaria associada a esta atenuação uma vez que a prolactina tem efeitos supressivos na inflamação (SUGIURA et al, 2012;NASCIMENTO et al, 2013;OCHOA-AMAYA et al, 2015). Para investigar essa hipótese, neste trabalho, ratas virgens foram tratadas com domperidona por 5 dias, um esquema de tratamento que promove hiperprolactinemia (NASELLO et al, 1997;OCHOA-AMAYA et al, 2010 LENCZOWSKI et al, 1999).…”