Short‐Term High‐Dose Vitamin E to Prevent Contrast Medium–Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo‐Controlled Trial

Rezaei, Yousef; Khademvatani, Kamal; Rahimi, Behzad; Khoshfetrat, Mehran; Arjmand, Nasim; Seyyed-Mohammadzad, Mir-Hossein

doi:10.1161/jaha.115.002919

Cited by 25 publications

(14 citation statements)

References 45 publications

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“…In all, 2 articles were excluded after reading their full texts. Finally, we included 4 eligible articles in the quantitative analysis ( 18 19 20 23 ). No relevant trials were identified from the hand search of relevant articles.…”

Section: Resultsmentioning

confidence: 99%

“…One trial evaluated participants who had participated in computed tomography ( 23 ), and the remaining trials evaluated participants having cardiac catheterization ( 18 19 20 ). Iopromide, which is a nonionic and low osmolar agent was used in 3 studies ( 19 20 23 ), and Iodixanol, which is a nonionic and iso-osmolar agent was carried out in 1 particular study ( 18 ). There were variations in vitamin E regimens (oral or intravenous, and starting 5 days before contrast administration or 12 hours before, and total dose of α-tocopherol of 1,000 mg or 2,800 mg).…”

Section: Resultsmentioning

confidence: 99%

“…Vitamin E (α-tocopherol) has been used as a dietary supplement due to its potent antioxidant and anti-inflammatory properties ( 17 ). The protective effects of vitamin E against CIAKI were reported ( 18 19 20 ), however it remains unclear. To examine whether vitamin E reduces the development of CIAKI, we systematically reviewed the randomized controlled trials (RCTs) that assessed the effectiveness of vitamin E in the prevention of CIAKI compared with placebo in high-risk adults undergoing procedures using contrast.…”

Section: Introductionmentioning

confidence: 99%

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Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis

et al. 2017

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Several clinical studies have proposed a protective role for vitamin E (α-tocopherol) against contrast-induced acute kidney injury (CIAKI). The aim of study was to assess the effects of vitamin E for the prevention of CIAKI. A systematic review and meta-analysis was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials (RCTs) reporting the effects of vitamin E on CIAKI development and measurements of renal function were included. Four trials including 623 participants were analyzed in the meta-analysis. All participants received intravenous hydration in addition to vitamin E or placebo. The incidence of the vitamin E group (5.8%) was lower than that of the control group (15.4%). Compared with the control, vitamin E significantly reduced the risk ratio (RR) of CIAKI by 62% (0.38; 95% confidence interval [CI], 0.22, 0.63; P < 0.010). In addition, vitamin E reduced serum creatinine (SCr) increase after contrast administration (standardized mean difference [SMD], −0.27; 95% CI, −0.49, −0.06; P = 0.010). However, changes in glomerular filtration rate (GFR) after contrast administration were not significantly different between vitamin E and the control group (SMD, 0.21; 95% CI, −0.01, 0.43; P = 0.060). Heterogeneity within the available trials was not observed. Our meta-analysis provides evidence that vitamin E plus hydration significantly reduced the risk of CIAKI in patients with renal impairment compared with hydration alone.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis

et al. 2017

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“…Su et al had identified 3 randomized trials on vitamin E prophylaxis against CIAKI (3)(4)(5). We pooled the results of these 3 studies (Figure 1) and calculated a pooled estimate of RR = 0.38 (95% CI 0.24-0.62), indicating that vitamin E significantly prevented CIAKI.…”

Section: To the Editormentioning

confidence: 97%

Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury

Rezaei

Hemilä

2017

American Journal of Kidney Diseases

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“…More recent studies have shown the positive effect of vitamin E administration before coronary procedures in the prevention of contrast-induced acute kidney injury in patients with CKD undergoing elective coronary procedures [ 79 , 80 ].…”

Section: Vitamin Ementioning

confidence: 99%

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

Signorini

Granata

Lupo

et al. 2017

IJMS

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Oxidative stress is a well-described imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system of cells and tissues. The overproduction of free radicals damages all components of the cell (proteins, lipids, nucleic acids) and modifies their physiological functions. As widely described, this condition is a biochemical hallmark of chronic kidney disease (CKD) and may dramatically influence the progression of renal impairment and the onset/development of major systemic comorbidities including cardiovascular diseases. This state is exacerbated by exposure of the body to uremic toxins and dialysis, a treatment that, although necessary to ensure patients’ survival, exposes cells to non-physiological contact with extracorporeal circuits and membranes with consequent mitochondrial and anti-redox cellular system alterations. Therefore, it is undeniable that counteracting oxidative stress machinery is a major pharmacological target in medicine/nephrology. As a consequence, in recent years several new naturally occurring compounds, administered alone or integrated with classical therapies and an appropriate lifestyle, have been proposed as therapeutic tools for CKD patients. In this paper, we reviewed the recent literature regarding the “pioneering” in vivo testing of these agents and their inclusion in small clinical trials performed in patients affected by CKD.

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Short‐Term High‐Dose Vitamin E to Prevent Contrast Medium–Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo‐Controlled Trial

Cited by 25 publications

References 45 publications

Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis

Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis

Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

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