Short-term, high-dose hydroxychloroquine corneal toxicity

Savage, Daniel E.; Plotnik, Ronald D.; Wozniak, Rachel A. F.

doi:10.1016/j.ajoc.2020.100713

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Similarly, previous case studies found that HCQ-induced vortex keratopathy is dose- and duration-dependent. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Low-dose oral hydroxychloroquine led to impaired vision in a child with renal failure

Huang

et al. 2021

Medicine

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Introduction: Hydroxychloroquine (HCQ) has received much attention in the treatment of coronavirus disease 2019 recently. However, it can cause irreversible vision loss. Few cases have been reported in pediatric patient with HCQ-related adverse reactions. Appropriate administration and early disease recognition are important for reducing the adverse drug reactions of HCQ. Patient concerns: We report a case of a 14-year-old Chinese girl who sought treatment for rapidly decreasing vision in the left eye over 3 days. The simulation results of the population pharmacokinetic model of HCQ revealed that the plasma concentration of HCQ abnormally increased before the visual acuity of the eye decreased. Diagnosis: She was diagnosed as HCQ related drug adverse reaction. Interventions: The daily dose of HCQ for this patient was adjusted from 100 mg/d to 50 mg/d. Outcomes: Follow-up for 6 months showed no more vision loss recurrence. However, the existing decreased visual acuity of the eye did not recover either. Conclusion: Although decreased visual acuity is an infrequent symptom, ophthalmologists should be aware of the possibility of HCQ concentration enrichment and consider minimizing HCQ use when a child with renal hypofunction seeks treatment for shortsightedness.

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“…Similarly, previous case studies found that HCQ-induced vortex keratopathy is dose- and duration-dependent. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Low-dose oral hydroxychloroquine led to impaired vision in a child with renal failure

Huang

et al. 2021

Medicine

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“…Damage to the cornea can manifest in the form of corneal opacity and corneal deposits. These deposits are typically referred to as corneal verticillata and are comprised of amorphous, yellow-white deposits scattered throughout the cornea[ 10 ]. Corneal verticillata can cause significant visual impairment if they are dense enough to obscure vision.…”

Section: To the Editormentioning

confidence: 99%

Ophthalmologic implications to consider when using hydroxychloroquine to treat COVID-19 and induced arthritis

Zeppieri

2023

World J Exp Med

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Orphan diseases are rare diseases that affect less than 200000 individuals within the United States. Most orphan diseases are of neurologic and genetic origin. With the current advances in technology, more funding has been devoted to developing therapeutic agents for patients with these conditions. In our review, we highlight emerging options for patients with neurologic orphan diseases, specifically including diseases resulting in muscular deterioration, epilepsy, seizures, neurodegenerative movement disorders, inhibited cognitive development, neuron deterioration, and tumors. After extensive literature review, gene therapy offers a promising route for the treatment of neurologic orphan diseases. The use of clustered regularly interspaced palindromic repeats/Cas9 has demonstrated positive results in experiments investigating its role in several diseases. Additionally, the use of adeno-associated viral vectors has shown improvement in survival, motor function, and developmental milestones, while also demonstrating reversal of sensory ataxia and cardiomyopathy in Friedreich ataxia patients. Antisense oligonucleotides have also been used in some neurologic orphan diseases with positive outcomes. Mammalian target of rapamycin inhibitors are currently being investigated and have reduced abnormal cell growth, proliferation, and angiogenesis. Emerging innovations and the role of genetic treatments open a new window of opportunity for the treatment of neurologic orphan diseases.

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Hydroxychloroquine

2020

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Short-term, high-dose hydroxychloroquine corneal toxicity

Cited by 6 publications

References 15 publications

Low-dose oral hydroxychloroquine led to impaired vision in a child with renal failure

Low-dose oral hydroxychloroquine led to impaired vision in a child with renal failure

Ophthalmologic implications to consider when using hydroxychloroquine to treat COVID-19 and induced arthritis

Hydroxychloroquine

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