Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample

Kupari, Markku; Virolainen, Juha; Koskinen, Pekka; Tikkanen, Matti J.

doi:10.1016/0002-9149(93)91103-o

Cited by 109 publications

(100 citation statements)

References 24 publications

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“…[16][17][18][19][20] The discrepancy may be related to selection bias and the limited number of study subjects in some studies. Our results revealed a decrease in parasympathetic tone (shown by a decrease in HF power and HR DB ) and autonomic imbalance (shown by an increase in LF/HF ratio) in obese II subjects with BMIX30 kg m À2 after carefully adjusting for other confounding factors.…”

Section: à2mentioning

confidence: 99%

“…Studies on the relationship between CAF and BMI have focused largely on obesity [11][12][13][14][15][16][17][18][19][20][21] and only one study has assessed HRV in underweight subjects. 22 However, the results on the effect of BMI on CAF are inconsistent.…”

mentioning

confidence: 99%

“…22 However, the results on the effect of BMI on CAF are inconsistent. [11][12][13][14][15][16][17][18][19][20][21][22] Most of the above studies were hospital-based. Only one study was population-based, but the number of study subjects was limited (n ¼ 93).…”

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confidence: 99%

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Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects

Wu¹,

Lu²,

Yang³

et al. 2008

Int J Obes

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Background:Little is known about the altered cardiac autonomic function (CAF) across different levels of body mass index (BMI), including underweight, normal weight, overweight and obesity. This study provides a thorough analysis to clarify the CAF change in subjects with underweight, overweight and obesity. Methods: According to the World Health Organization (WHO) Asia-Pacific BMI cutoffs, a total of 1437 participants were classified as underweight (n ¼ 74), normal weight (n ¼ 588), overweight (n ¼ 313), obesity I (n ¼ 390) and obesity II (n ¼ 72). CAF was determined by standard deviation of normal-to-normal (SDNN) intervals or RR intervals, power spectrum in low (LF) and high frequency (HF) (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz), and LF/HF ratio at supine for 5 min, the ratio between the 30th and the 15th RR interval after standing from the supine position (30/15 ratio) and the average heart-rate change while taking six deep breaths in 1 min (HR DB ). Results: There were significant differences in age, gender, socioeconomic status, blood pressure, HOMA insulin resistance index, fasting glucose, cholesterol, triglyceride and high-density lipoprotein (HDL)-C, and the prevalence of hypertension, ischemic/left bundle branch block (LBBB) electrocardiography (EKG) pattern, current smoking and alcohol use among subjects with underweight, normal weight, overweight, obesity I and II. Univariate analysis showed that SDNN, HR DB , HF power and the square root of the LF/HF ratio differed among these five groups. Multivariate analysis showed that obesity I and II were inverse correlates of HR DB and HF power. Overweight, obesity I and II were positively associated with the square root of the LF/HF ratio. No BMI status was related to SDNN, 30/15 ratio or LF power. Underweight was not the independent correlate of any CAF indices. Conclusions: The risk for altered CAF is significant in overweight and obese subjects, independent of cardiovascular risk factors. Underweight is not apparently associated with CAF change.

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Section: à2mentioning

confidence: 99%

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confidence: 99%

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Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects

Wu¹,

Lu²,

Yang³

et al. 2008

Int J Obes

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“…High sodium 9 and alcohol 10,11 intakes, obesity, 12 smoking, 13,14 low heart rate variability 15,16 and in some studies high plasma renin activity (PRA) 17 are associated with increased risk of cardiovascular events. Obesity, 18 smoking, 19,20 and intakes of alcohol 20,21 and salt 22 may also modulate heart rate variability. However, surprisingly little is known of the possible interactions between lifestyle factors, blood pressure, PRA and heart rate variability.…”

Section: Introductionmentioning

confidence: 99%

Reduced heart rate variability in hypertension: associations with lifestyle factors and plasma renin activity

et al. 2003

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Limited information exists on the relations between heart rate variability, hypertension, lifestyle factors and renin-angiotensin-aldosterone system. A total of 191 newly diagnosed yet untreated hypertensive men and women, 35-54 years of age, were compared with an ageand gender-stratified random population sample of 105 normotensive men and women to find out independent determinants of heart rate variability. Heart rate variability was computed from 5-min ECG time series using the standard deviation of normal-to-normal RR intervals (SDNN), the square root of the mean of squared differences between adjacent normal RR intervals (RMSSD) and the fast Fourier transform spectral analysis. All absolute measures of heart rate variability were reduced in hypertension (Po0.001 for each, ANOVA). In multivariate regression analyses, reduced heart rate variability was independently associated with higher heart rate (Po0.001 for all absolute measures of heart rate variability), higher age (P=0.001 for SDNN, total and LF powers; Po0.001 for RMSSD and HF power) and higher mean arterial pressure (Po0.05 for total power, Po0.01 for the other absolute measures) but not with sodium and alcohol intakes, body mass index and smoking. Increased plasma renin activity (PRA) was an independent attributor of reduced HF power (Po0.05) and reduced RMSSD (Po0.01). Increased blood pressure and heart rate are associated with decreased heart rate variability without any direct effects on heart rate variability of lifestyle factors. High PRA is an independent determinant of diminished modulation of vagal activity.

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“…Em seu estudo, Kupari et al 29 avaliaram o efeito do número de cigarros sobre índices da VFC, observando redução da mesma em indivíduos que fumavam 10 cigarros ou mais por dia quando comparados a não-fumantes ou àqueles que fumavam menos de 10 cigarros por dia.…”

Section: Discussionunclassified

Comparação Da Modulação Autonômica Cardíaca Durante Esforço De Fumantes E Não Fumantes

Alves

Oliveira

Alves

et al. 2015

Rev Bras Med Esporte

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RESUMOIntrodução: O tabagismo é uma das principais causas de morbimortalidade em todo o mundo. Indivíduos fumantes têm risco aumentado de desenvolver disfunção autonômica, a qual pode ser avaliada tanto pela variabilidade da frequência cardíaca (VFC) como pela frequência cardíaca de recuperação (FCRec). A maioria dos estudos envolvendo esta análise é realizada em adultos de idade avançada e na condição de repouso. Objetivos: Comparar a atividade autonômica cardíaca em repouso e esforço, em homens jovens, fumantes e não fumantes. Métodos: Trinta e dois jovens voluntários, (idade 22,0 ± 2,8 anos) foram distribuídos em dois grupos: o grupo fumante (GF; n=15) e o não fumante (GNF; n=17). Realizou-se o teste de Cooper, com análise da VFC pelo cardiofrequencímetro Polar ® s810i, em repouso e durante o esforço e FCRec. Resultados: No GF, 73% foram classificados com nível de dependência nicotínica "muito baixa" segundo questionário de Fargeström. A classificação de ativos e muito ativos pelo questionário IPAQ correspondeu a mais de 50% da amostra em ambos os grupos. Não se observou diferenças significativas entre os grupos na VFC, tanto no repouso quanto no esforço. Entretanto, em cada grupo, notou-se diferença na maioria dos índices de VFC do repouso para o esforço. No teste de Cooper não foram observadas diferenças significativas na FCmédia, FCpico e de FCRec entre os grupos, mas notou-se uma melhor capacidade funcional no GNF pela distância caminhada (2050,2 ± 300,0 vs. 1780,3 ± 390,4 m, p=0,036). Conclusão: O GF apresentou menor capacidade funcional e ativação parassimpática durante o esforço, além de menores índices de VFC durante repouso, o que pode sugerir um comprometimento precoce na modulação autonômica cardíaca.Palavras-chave: exercício, hábito de fumar, disautonomias primárias. , were divided into two groups: the smoking group (SG, n = 17 (2050.2 ± 300.0 vs. 1780.3 ± 390.4m, p = 0.036 ABSTRACT Introduction: Smoking is one of the major causes of morbidity and mortality worldwide. Smokers have an increased risk of developing autonomic dysfunction, which can be evaluated by both heart rate variability (HRV) and heart rate recovery (HRRec). Most studies involving this analysis is performed on adults of advanced age and in condition of rest. Objectives: To compare the cardiac autonomic activity, at rest and during exercise in young men

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Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample

Cited by 109 publications

References 24 publications

Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects

Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects

Reduced heart rate variability in hypertension: associations with lifestyle factors and plasma renin activity

Comparação Da Modulação Autonômica Cardíaca Durante Esforço De Fumantes E Não Fumantes

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