Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups

Lombardi, Valter; Cagiao, A.M. Martínez; Fernández‐Novoa, L.; Alvarez, X.A.; Corzo, Marı́a D.; Zas, R.; Sampedro, Carolina; Cacabelos, Ramón

doi:10.1016/s0271-5317(01)00361-x

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Adipose tissue, generated by a HFD, may modulate its effect in serum by providing intrinsic adiponectins, leptins and n-3 fatty acids. These findings are in line with animal model experiments conducted by our group [25][26][27][28][29][30][31] and others. RCI-1502 potentially blocks the excessive release of free fatty acids into the circulating serum, avoiding ectopic lipid deposition, thereby preventing obesity in mice.…”

Section: The Effects Of Rci-1502 On Hfd-associated Weight Gain In Micesupporting

confidence: 91%

“…The current study aims include not only contributions to new knowledge of pathological effects of obesity on mice metabolism, but also the use of a new natural marine bioactive compound capable of modulating cardiovascular risk and the related immune response [25][26][27][28][29][30]. Here we hypothesized that supplementing mice on a high-fat diet with RCI-1502 (HFD/CS mice) would decrease their TC and LDL levels since it contains 60-80% lipoproteins and polyunsaturated fatty acid (EPA and DHA content) [25,31].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

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Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

Carrera¹,

Corzo²,

Naidoo³

et al. 2023

Int. J. Med. Sci.

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Obesity is a major health challenge worldwide, with implications for diabetes, hypertension and cardiovascular disease (CVD). Regular consumption of dark-meat fish is linked to a lower incidence of CVD and associated metabolic disorders due to the presence of long-chain omega-3 fatty acid ethyl esters in fish oils. The aim of the present study was to determine whether a marine compound like a sardine lipoprotein extract (RCI-1502), regulates fat accumulation in the heart of a high-fat diet-induced (HFD) mouse model of obesity. To investigate its effects in the heart and liver, we conducted a randomized, 12-week placebo-controlled study in which we analyzed the expression of vascular inflammation markers, obesity biochemical patterns and related CVD pathologies. Male HFD-fed mice treated with a RCI-1502-supplemented diet showed reduced body weight, abdominal fat tissue and pericardial fat pad mass density without systemic toxicity. RCI-1502 significantly reduced triacylglyceride, low-density lipoprotein and total-cholesterol concentrations in serum, but increased HDL-cholesterol levels. Our data show that RCI-1502 is beneficial for reducing obesity associated with a long-term HFD, possibly by exerting a protective effect on lipidic homeostasis, indicated also by histopathological analysis. These results collectively indicate that RCI-1502 acts as a cardiovascular therapeutic nutraceutical agent, which modulates fat-induced inflammation and improves metabolic health.

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Section: The Effects Of Rci-1502 On Hfd-associated Weight Gain In Micesupporting

confidence: 91%

Section: Ivyspring International Publishermentioning

confidence: 99%

Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

Carrera¹,

Corzo²,

Naidoo³

et al. 2023

Int. J. Med. Sci.

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“…p values were calculated using the MannWhitney U-test (two-tailed). In a previous work we showed that the supplementation with E-SAR-94010R a marine fish extract obtained from S. pilchardus, with a high content of long-chain polyunsaturated fatty acids, was able to modulate T H 1 and T H 2 cell generation, their cytokine production, and cell proliferation and to improve the immunological status of pregnant rats and their sucking pups [40]. These results indicated that the secondary response, which is typically more specific, rapid and of a greater magnitude, was enhanced by gestational E-SAR-94010R supplementation.…”

Section: Discussionmentioning

confidence: 99%

Effects of fish-derived lipoprotein extracts on activation markers, Fas expression and apoptosis in peripheral blood lymphocytes

Lombardi

Fernández‐Novoa

Etcheverría

et al. 2005

International Immunopharmacology

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“…LipoEsar is also rich in potassium, phosphorous and calcium, and in vitamins B5 and C [ 19 ]. In vitro and in vivo preclinical studies show that LipoEsar lowers serum triglyceride, cholesterol and glucose levels, and modulates immunological parameters by increasing monocyte, leukocyte and lymphocyte cell counts [ 18 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomic and Global DNA Methylation Modulation in Lipid Metabolism Disorders with a Marine-Derived Bioproduct

Martínez-Iglesias

Naidoo

Corzo

et al. 2023

Biology

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Dyslipidemia is a significant risk factor for cardiovascular disease and stroke. Our recent findings showed that RCI-1502, a bioproduct derived from the muscle of the European S. pilchardus, has lipid-lowering effects in the liver and heart in high-fat diet (HFD) fed mice. In the present follow-up study, we investigated the therapeutic potential of RCI-1502 on gene expression and DNA methylation in HFD-fed mice and in patients with dyslipidemia. Using LC-MS/MS, we identified 75 proteins in RCI-1502 that are primarily involved in binding and catalytic activity and which regulate pathways implicated in cardiovascular diseases. In HFD-fed mice, RCI-1502 treatment significantly reduced the expression of cardiovascular disease-related genes, including vascular cell adhesion molecule and angiotensin. RCI-1502 also decreased DNA methylation levels, which were elevated in HFD-fed mice, to levels similar to those in control animals. Furthermore, peripheral blood leukocyte DNA from dyslipidemic patients exhibited higher DNA methylation levels than healthy individuals, suggesting a potential association with cardiovascular risk. Serum analysis also revealed that RCI-1502 treatment regulated cholesterol and triglyceride levels in patients with dyslipidemia. Our findings appear to suggest that RCI-1502 is an epigenetic modulator for the treatment of cardiovascular diseases, specifically in individuals with dyslipidemia.

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Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups

Cited by 8 publications

References 27 publications

Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

Effects of fish-derived lipoprotein extracts on activation markers, Fas expression and apoptosis in peripheral blood lymphocytes

Proteomic and Global DNA Methylation Modulation in Lipid Metabolism Disorders with a Marine-Derived Bioproduct

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