Short-term follow-up of cryopreserved allograft valves and valved conduits from the CryoLife clinical registry

Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts

“…All allografts in this study were obtained from CryoLife, Inc. Standard cryopreserved allograft material was considered to be allograft material that was harvested and cryopreserved according to previously published methods. 12,13 Decellularized cryopreserved allograft material (SynerGraft; CryoLife, Inc) is prepared by harvesting techniques similar to those used for standard allograft material but undergoes a decellularization process that first involves cell lysis in hypotonic sterile water solution. After that, the allograft tissue is equilibrated in buffer and is treated by enzymatic digestion of nucleic acids with a combined solution of ribonuclease and deoxyribonuclease.…”