Short-term folinic acid supplementation improves vascular reactivity in HIV-infected individuals: A randomized trial

Grigoletti, Shana Souza; Guindani, Grace; Moraes, Roque; Ribeiro, Jorge Pinto; Sprinz, Eduardo

doi:10.1016/j.nut.2013.01.015

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…The remaining 19 trials included 5730 participants, with most receiving either mono‐ or combination ART ( Allard 1998 CAN ; Coodley 1993 USA ; Coodley 1996 USA ; Humphrey 1999 USA ; Semba 1998 USA ), or highly active antiretroviral therapy (HAART) ( Asdamongkol 2013 THA ; Bang 2012 DEN ; Baum 2010 USA ; Burbano 2002 USA ; Dougherty 2015 USA ; Giacomet 2013 ITA ; Guwatudde 2015 UG ; Green 2005 SGP ; Grigoletti 2013 BRA ; Hurwitz 2007 USA ; Isanaka 2012 TZA ; Overton 2015 USA ; Semba 2007 USA ; Stallings 2014 USA ). Many of these trials were small with fewer than 100 participants, with the exception of Isanaka 2012 TZA which had more than 3000 participants.…”

Section: Resultsmentioning

confidence: 99%

“… Africa: Botswana ( Baum 2013 BWA ), Kenya ( Baeten 2002 KEN ; McClelland 2004 KEN ), Guinea‐Bissau ( Wejse 2009 GNB ), Malawi ( Semba 2007 MWI ), Nigeria ( Lawson 2010 NIG ), Rwanda ( Kamwesiga 2015 RWA ), Tanzania ( Range 2006 TZA ; Isanaka 2012 TZA ; Villamor 2008 TZA ), Uganda ( Guwatudde 2015 UG ), and Zambia ( Kelly 1999 ZMB ; Kelly 2008 ZMB ) Asia: China ( Zhao 2010 CHN ), Singapore ( Green 2005 SGP ), and Thailand ( Asdamongkol 2013 THA ; Jiamton 2003 THA ) North America: Canada ( Allard 1998 CAN ) and USA ( Baum 2010 USA ; Burbano 2002 USA ; Coodley 1993 USA ; Coodley 1996 USA ; Dougherty 2015 USA ; Humphrey 1999 USA ; Hurwitz 2007 USA ; Overton 2015 USA ; Semba 1998 USA ; Semba 2007 USA ; Stallings 2014 USA ) South America: Brazil ( Grigoletti 2013 BRA ) and Peru ( Cárcamo 2006 PER ) Europe: Denmark ( Bang 2012 DEN ) and Italy ( Giacomet 2013 ITA ) …”

Section: Resultsmentioning

confidence: 99%

“… Multiple micronutrients (10 trials; 3533 participants: Baum 2013 BWA ; Guwatudde 2015 UG ; Jiamton 2003 THA ; Kelly 1999 ZMB ; Kelly 2008 ZMB ; McClelland 2004 KEN ; Range 2006 TZA ; Semba 2007 MWI ; Villamor 2008 TZA ; Zhao 2010 CHN ) Vitamin A (4 trials; 581 participants: Baeten 2002 KEN ; Coodley 1993 USA ; Humphrey 1999 USA ; Semba 1998 USA ) Vitamin D (5 trials; 447 participants: Bang 2012 DEN ; Giacomet 2013 ITA ; Overton 2015 USA ; Stallings 2014 USA ; Wejse 2009 GNB ) Vitamin E combined with vitamin C (1 trial, 49 participants: Allard 1998 CAN ) Folinic acid (1 trial, 30 participants: Grigoletti 2013 BRA ) Zinc (6 trials, 826 participants: Asdamongkol 2013 THA ; Baum 2010 USA ; Cárcamo 2006 PER ; Green 2005 SGP ; Lawson 2010 NIG , Range 2006 TZA ) Selenium (4 trials, 1308 participants: Baum 2013 BWA ; Burbano 2002 USA ; Hurwitz 2007 USA ; Kamwesiga 2015 RWA ) …”

Section: Resultsmentioning

confidence: 99%

“…All but 19 trials were funded either fully or partly from government sources ( Allard 1998 CAN ; Asdamongkol 2013 THA ; Baeten 2002 KEN ; Baum 2010 USA ; Baum 2013 BWA ; Burbano 2002 USA ; Coodley 1993 USA ; Coodley 1996 USA ; Green 2005 SGP ; Grigoletti 2013 BRA ; Humphrey 1999 USA ; Hurwitz 2007 USA ; Isanaka 2012 TZA ; Jiamton 2003 THA ; Kelly 1999 ZMB ; McClelland 2004 KEN ; Semba 1998 USA ; Stallings 2014 USA ; Villamor 2008 TZA ); five were fully or partly funded by pharmaceutical companies ( Bang 2012 DEN ; Coodley 1993 USA ; Jiamton 2003 THA ; Kelly 1999 ZMB ; Overton 2015 USA ); and one trial did not provide the source of funding ( Zhao 2010 CHN ).…”

Section: Resultsmentioning

confidence: 99%

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Micronutrient supplementation in adults with HIV infection

Visser¹,

Durão

Sinclair

et al. 2017

Cochrane Database of Systematic Reviews

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Background Micronutrient deficiencies are common among adults living with HIV disease, particularly in low‐income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. Objectives To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV‐related morbidity of HIV‐positive adults (excluding pregnant women). Search methods We performed literature searches from January 2010 to 18 November 2016 for new randomized controlled trials (RCTs) of micronutrient supplements since the previous review included all trials identified from searches prior to 2010. We searched the CENTRAL (the Cochrane Library), Embase, and PubMed databases. Also we checked the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) and the ClinicalTrials.gov trials registers. We also checked the reference lists of all new included trials. Selection criteria We included RCTs that compared supplements that contained either single, dual, or multiple micronutrients with placebo, no treatment, or other supplements. We excluded studies that were primarily designed to investigate the role of micronutrients for the treatment of HIV‐positive participants with metabolic morbidity related to highly active antiretroviral therapy (HAART). Primary outcomes included all‐cause mortality, morbidity, and disease progression. Data collection and analysis Two review authors independently selected trials for inclusion, and appraised trial quality for risk of bias. Where possible, we presented results as risk ratios (RR) for dichotomous variables, as hazard ratios (HRs) for time‐to‐event data, and as mean differences (MD) for continuous variables, each with 95% confidence intervals (CIs). Since we were often unable to pool the outcome data, we tabulated it for each comparison. We assessed the certainty of the evidence using the GRADE approach. Main results We included 33 trials with 10,325 participants, of which 17 trials were new trials. Ten trials compared a daily multiple micronutrient supplement to placebo in doses up to 20 times the dietary reference intake, and one trial compared a daily standard dose with a high daily dose of multivitamins. Nineteen trials compared supplementation with single or dual micronutrients (such as vitamins A and D, zinc, and selenium) to placebo, and three trials compared different dosages or combinations of micronutrients. Multiple micronutrients We conducted analyses across antiretroviral therapy (ART)‐naive adults (3 trials, 1448 participants), adults on antiretroviral therapy (ART) (1 trial, 400 participants), and ART‐naive adults with concurrent active tuber...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Micronutrient supplementation in adults with HIV infection

Visser¹,

Durão

Sinclair

et al. 2017

Cochrane Database of Systematic Reviews

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“…These deficiencies are prevalent even before the development of symptoms of disease and are associated with accelerated HIV disease progression [ 4 – 6 ]. A number of studies conducted among HIV-infected adults during the pre-highly active antiretroviral therapy (HAART) era, have shown that multivitamin supplementation enhances immune reconstitution, reduces viral load, improves overall clinical outcomes, and reduces mortality [ 7 – 14 ]. However, only a few trials have explored the effect of multivitamin supplementation in relation to HIV progression during HAART, and some have reported beneficial treatment outcomes [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of standard dose multivitamin supplementation on disease progression in HIV-infected adults initiating HAART: a randomized double blind placebo-controlled trial in Uganda

Guwatudde

Wang

Ezeamama³

et al. 2015

BMC Infect Dis

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BackgroundEfficacy trials investigating the effect of multivitamin (MV) supplementations among patients on Highly Active Antiretroviral Therapy (HAART) have so far been inconclusive. We conducted a randomized, double blind, placebo controlled trial to determine the effect of one recommended daily allowance (RDA) of MV supplementation on disease progression in patients initiating HAART.MethodsEligible subjects were randomized to receive placebo or MV supplementation including vitamins B-complex, C and E. Participants were followed for up to 18 months. Primary endpoints were: change in CD4 cell count, weight and quality of life (QoL). Secondary endpoints were: i) development of a new or recurrent HIV disease progression event, including all-cause mortality; ii) switching from first- to second-line antiretroviral therapy (ART); and iii) occurrence of an adverse event. Intent-to-treat analysis, using linear regression mixed effects models were used to compare changes over time in the primary endpoints between the study arms. Kaplan-Meier time-to-event analysis and the log-rank test was used to compare HIV disease progression events and all-cause mortality.ResultsFour hundred participants were randomized, 200 onto MV and 200 onto placebo. By month 18, the average change in CD4 cell count in the MV arm was 141 cells/uL compared to 147 cells/uL in the placebo arm, a mean difference of −6 · 17 [95 % CI −29 · 3, 16 · 9]. The average change in weight in the MV arm was 3 · 9 kg compared to 3 · 3 kg in the placebo arm, a mean difference of 0 · 54 [95 % CI −0 · 40, 1 · 48]; whereas average change in QoL scores in the MV arm was 6 · 8 compared to 8 · 8 in the placebo arm, a mean difference of −2.16 [95 % CI −4 · 59,0 · 27]. No significant differences were observed in these primary endpoints, or in occurrence of adverse events between the trial arms.ConclusionsOne RDA of MV supplementation was safe but did not have an effect on indicators of disease progression among HIV infected adults initiating HAART.Trial registrationClinical trials NCT01228578, registered on 15th October 2010.

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Biosystems Engineering: Biofactories for Food Production in the Century XXI

Guevara-González¹,

Torres-Pacheco²

2014

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Short-term folinic acid supplementation improves vascular reactivity in HIV-infected individuals: A randomized trial

Cited by 12 publications

References 39 publications

Micronutrient supplementation in adults with HIV infection

Micronutrient supplementation in adults with HIV infection

The effect of standard dose multivitamin supplementation on disease progression in HIV-infected adults initiating HAART: a randomized double blind placebo-controlled trial in Uganda

Biosystems Engineering: Biofactories for Food Production in the Century XXI

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