Short-term exposure to enrofloxacin causes hepatic metabolism disorder associated with intestinal flora dysbiosis in adult marine medaka (Oryzias melastigma)

Wang, Meiru; Qin, Yifan; Liu, Yifan; Yang, Hui; Wang, Jun; Ru, Shaoguo; Cui, Pengfei

doi:10.1016/j.marpolbul.2023.114966

Cited by 10 publications

(1 citation statement)

References 83 publications

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“…Many studies have demonstrated the deleterious impacts of antibiotic administration on the intestinal microbiota [ 5 , 16 ]. These studies have shown the capacities of antibiotics to modify the compositional dynamics of the intestinal microbial community to reduce the abundances of probiotic bacteria and decrease the relative abundances of pathogenic bacteria, but also to influence the overall metabolic profile of the intestinal flora [ 17 , 18 ]. These perturbations make it difficult to restore the microbial community structure to a state of healthy equilibrium, with adverse consequences for the host [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Impact of Pineapple–Whey Protein Fermentation Products on Cefixime-Induced Intestinal Flora Dysbiosis in Mice Using 16S Sequencing and Untargeted Metabolomics Techniques

Luo,

Xiao,

et al. 2024

Foods

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In our previous study, a new fermented food (PWF) created by utilizing pineapple by-products and whey proteins as a matrix via co-fermentation with lactic acid bacteria and yeast was developed, and, in the current study, we examined the impact of a pineapple–whey protein fermentation product on a cefixime-induced dysbiosis model in mice using 16S sequencing and untargeted metabolomics techniques. The results indicated that the pineapple–whey protein fermentation product played a positive role in restoring the intestinal flora. In this study, cefixime reduced the overall abundance of intestinal flora and decreased the relative abundance of probiotics in the gut, while also inhibiting amino acid metabolism. The addition of PWF normalized the intestinal flora to a steady state, significantly increasing the populations of Weissella, Lactococcus, Faecalibaculum, and Bacteroides acidophilus, while decreasing the numbers of Akkermansia and Escherichia-Shigella. Additionally, PWF modulated microbial metabolites, such as L-glutamate and L-threonine, and upregulated amino-acid-related metabolic pathways, including those involving glycine, serine, and threonine. In conclusion, PWF can alleviate intestinal flora dysbiosis and metabolic disturbances induced by antibiotic interventions. It is suggested that PWF could be a potential dietary strategy for patients with antibiotic-associated diarrhea.

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