Short-term exposure to ambient particulate matter and outpatient visits for respiratory diseases among children: A time-series study in five Chinese cities

Li, Meng; Jing, Tang; Yang, Huihua; Zhao, Lei; Liu, Ya; Xu, Haoli; Fan, Yali; Hong, Jun Young; Long, Zhen; Li, Xiaojuan; Zhang, Jianduan; Guo, Wenting; Liu, Miao; Yang, Liangle; Lai, Xuefeng; Zhang, Xiaomin

doi:10.1016/j.chemosphere.2020.128214

Cited by 21 publications

(10 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The World Health Organization (WHO) estimated that children under 5 years of age bear more than 40% of the burden of environment-related diseases despite accounting for only 10% of the global population ( 12 – 14 ). Air pollution has been extensively studied as a direct cause of child health problems, such as adverse birth outcomes, impaired cognitive and behavioral development ( 15 – 17 ), and respiratory diseases ( 18 , 19 ). Additionally, environmental exposures, including prenatal exposure to metals, organochlorine pesticides, and other persistent organic pollutants (POPs), have been reported to be associated with adverse birth outcomes ( 4 , 20 , 21 ), including PTB, low birth weight (LBW), SGA, and other birth anthropometric features (BW, HC, and BL).…”

Section: Introductionmentioning

confidence: 99%

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Gui

Chen

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundA large body of emerging evidence suggests that per- and polyfluoroalkyl substances (PFAS) affect birth outcomes in various pathways, but the evidence is inconsistent. Therefore, this study aimed to systematically review the epidemiological evidence on PFAS exposure and birth outcomes.MethodsThree electronic databases were searched for epidemiological studies through February 13, 2021. We used random-effects meta-analysis for eight birth outcome indicators to calculate summary effect estimates for various exposure types. The risk of bias and the overall quality and level of evidence for each exposure-outcome pair were assessed.ResultsThe initial search identified 58 potentially eligible studies, of which 46 were ultimately included. Many PFAS were found to have previously unrecognized statistically significant associations with birth outcomes. Specifically, birth weight (BW) was associated with PFAS, with effect sizes ranging from −181.209 g (95% confidence interval (CI) = −360.620 to −1.798) per 1 ng/ml increase in perfluoroheptanesulfonate (PFHpS) to −24.252 g (95% CI = −38.574 to −9.930) per 1 ln (ng/ml) increase in perfluorodecaoic acid (PFDA). Similar patterns were observed between other PFAS and birth outcomes: perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with birth length (BL) and ponderal index (PI), PFOS and perfluorododecanoic acid (PFDoDA) with head circumference (HC), PFHpS with gestational age (GA), and perfluorononanoic acid (PFNA) and PFHpS with preterm birth (PTB). Additionally, PFDA showed a statistically significant association with small for gestational age (SGA). The level of the combined evidence for each exposure-outcome pair was considered to be “moderate”.ConclusionThis study showed that PFAS exposure was significantly associated with increased risks of various adverse birth outcomes and that different birth outcome indicators had different degrees of sensitivity to PFAS. Further studies are needed to confirm our results by expanding the sample size, clarifying the effects of different types or doses of PFAS and the time of blood collection on birth outcomes, and fully considering the possible confounders.

show abstract

Section: Introductionmentioning

confidence: 99%

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Gui

Chen

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…These may interpret why PMc would have robust and stronger effects and why cumulative exposure would show higher risks. Previous studies have suggested that patients of younger ages should be considered to be susceptible to PM-related respiratory hospital admissions (13,26,27). A study conducted between two Chinese metropolitan populations also found that children younger than 14 years suffered higher PM-induced risks of emergency department visits (24).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of size-specific particulate matter on the number of visits to outpatient fever clinics: A time-series analysis in Zhuhai, China

He²,

Liu³

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

IntroductionWhile many studies have investigated the adverse effects of particulate matter (PM), few of them distinguished the different effects of PM2.5, PM10, and coarse PM (PMc) on outpatients with fever. Our study aimed to estimate and compare the acute cumulative effects of exposure to three size-specific particles on the number of visits to outpatient fever clinics.MethodsTo examine the association between daily PM concentrations and outpatients in fever clinics, a generalized additive Poisson model was applied, stratified by sex, age, and season.ResultsOur study included 56,144 outpatient visits in Zhuhai, from January 2020 to June 2021. On the current day, each 10 mg/m3 increment of PM10 and PMc were estimated to increase fever clinic visits by 1.74% (95% CI: 0.59%, 2.91%) and 4.42 % (2.30%, 6.58%), respectively. Cumulative effects enhanced from lag01 to lag05 for PM10 and PMc, and PMc had the strongest impact [ER = 8.92% (5.91%, 12.01%) at lag05]. Female outpatients and outpatients aged 14 years and above had an increased PM-related risk. During the cold season, significant effects could be observed for the three-size PM, while only PMc showed the impact during the warm season.DiscussionOverall, the three size-specific PM exerted different effects on the fever clinic visits. Strategies to control the concentrations of PM are still necessary, especially against PM10 and PMc.

show abstract

“…The use of Bleomycin can aggravate the process of pulmonary fibrosis by upregulating the expression of P53 and P21 in A549 human alveolar epithelial cells ( Muthuramalingam et al, 2020 ). In response to silica, upregulation of p53 activates the RMRP/miR122 signaling pathway and promotes epithelial-mesenchymal transition (EMT), leading to the progression of pulmonary fibrosis in BALB/c mice ( Li et al, 2021 ). Accordingly, the lung tissue damage and collagen deposition in p53 deficient mice are significantly reduced compared with wild-type mice, suggesting that inhibition of p53 expression could delay the progression of lung fibrosis ( Wu et al, 2020 ).…”

Section: P53 Is Required For the Anti-fibrosis Processmentioning

confidence: 99%

The role of p53 in liver fibrosis

Zhang

2022

Front. Pharmacol.

View full text Add to dashboard Cite

The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and development of liver fibrosis. The abundant post-translational processing and modification endow the functional diversity of p53. Considering the relationship between p53 and liver fibrosis, drug intervention targeting p53 or management of p53 regulation might be effective strategies to treat liver fibrosis. Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, etc) and the role of p53 in the development of liver fibrosis, and propose possible interventions to prevent the pathogenic processes of liver fibrosis.

show abstract

Short-term exposure to ambient particulate matter and outpatient visits for respiratory diseases among children: A time-series study in five Chinese cities

Cited by 21 publications

References 62 publications

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Differential effects of size-specific particulate matter on the number of visits to outpatient fever clinics: A time-series analysis in Zhuhai, China

The role of p53 in liver fibrosis

Contact Info

Product

Resources

About