Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity

Barry, Julianne; Simtchouk, Svetlana; Durrer, Cody; Jung, Mary E.; Mui, Alice; Little, Jonathan P.

doi:10.1016/j.cyto.2018.05.035

Cited by 49 publications

(56 citation statements)

References 46 publications

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“…This newly proposed short-term intervention indicated an overall unchanged effect on body composition parameters, which was in line with other exercise interventions [19,17,[28][29][30]. However, Robinson et al [15] reported a significant reduction in body weight and BMI following 2 short-term exercise programs (highintensity aerobic training, 4 × 1 min cycling exercise, and moderate-intensity exercise, 50 min of continuous cycling exercises) in the OW/OB prediabetic patients.…”

Section: Discussionsupporting

confidence: 69%

“…In this study, a slight but significant increase was observed in FFM (2.06%) and SMM (1.9%). The combined interventions were effective in increasing muscle mass, while there existed no report on high-intensity aerobic training [28,29]. The incidence of cardiovascular disease (CVD) and its associated total mortality rate could be predicted by evaluating body composition [31], while both the increase in FM and FFM reduction could generate identical %FM values in different conditions from obesity to hidden cachexia; consequently, the effective changes in body composition could not be reflected by %FM alone.…”

Section: Discussionmentioning

confidence: 99%

“…Soltani/Esmaeil/Marandi/Hovsepian/ Momen/Shahsanai/KelishadiPublic Health Genomics 2020;23:[26][27][28][29][30][31][32][33][34][35][36] …”

mentioning

confidence: 99%

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Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Soltani¹,

Esmaeil²,

Marandi³

et al. 2020

Public Health Genomics

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Obesity is commonly associated with immunometabolic dysfunctions. Activation of inflammatory macrophages through TLR4 (toll-like receptor 4) and the anti-inflammatory impact of exercise have been and are the new concerns among researchers. A new short-term combined high-intensity interval training was proposed in young sedentary overweight/obese females. All participants were allocated to one of two groups: the exercise group (EG) and the control group (CG), where the EG participated in a 2-week combined training and the CG continued its routine lifestyle. Gene expression levels of TLR4, NF-κB (nuclear factor κB), and IRF3 (interferon regulatory factor 3) were assessed by real-time PCR. Physiological, anthropometric, and biomedical metabolic factors were assessed. The between-group comparisons indicated a tendency to a decrease in NF-κB gene expression in the EG. The IRF3 levels were not significantly changed compared to CG and the levels before training. Fasting glucose levels and β-cell function revealed a significant improvement in EG. These findings indicated that this protocol decreased meta-inflammation levels and improved insulin resistance independent of body composition changes. Consequently, combined training may be recommended as a therapeutic approach in metabolic diseases.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Soltani¹,

Esmaeil²,

Marandi³

et al. 2020

Public Health Genomics

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“…Besides, it has a pronounced effect on the metabolism of glucose [89,159] and lipids [160] in COPD patients. The mechanism by which exercise improves COPD dysfunction may be related to its effects on inflammation: exercise regulates chronic inflammation [161][162][163]. Davidson et al [164] found that exercise inhibits the level of inflammatory factors in COPD sputum, which indicates an anti-inflammatory effect.…”

mentioning

confidence: 99%

Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

et al. 2020

BioMed Research International

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Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are also closely related to inflammation processes. Further insights into the interactions of inflammation and glucose and lipid metabolism might therefore inspire novel therapeutic interventions to promote lung rehabilitation. Chemerin, as a recently discovered adipokine, has been shown to play a role in inflammatory response and glucose and lipid metabolism in many diseases (including COPD). Chemerin recruits inflammatory cells to sites of inflammation during the early stages of COPD, leading to endothelial barrier dysfunction, early vascular remodeling, and angiogenesis. Moreover, it supports the recruitment of antigen-presenting cells that guide immune cells as part of the body’s inflammatory responses. Chemerin also regulates metabolism via activation of its cognate receptors. Glucose homeostasis is affected via effects on insulin secretion and sensitivity, and lipid metabolism is changed by increased transformation of preadipocytes to mature adipocytes through chemerin-binding receptors. Controlling chemerin signaling may be a promising approach to improve various aspects of COPD-related dysfunction. Importantly, several studies indicate that chemerin expression in vivo is influenced by exercise. Although available evidence is still limited, therapeutic alterations of chemerin activity may be a promising target of therapeutic approaches aimed at the rehabilitation of COPD patients based on exercises. In conclusion, chemerin plays an essential role in COPD, especially in the inflammatory responses and metabolism, and has a potential to become a target for, and a biomarker of, curative mechanisms underlying exercise-mediated lung rehabilitation.

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“…Two LPS-pathway proteins, including cluster of differentiation 14 (CD14) and LPSbinding protein (LBP), are widely used as indirect measures of response to the LPS endotoxin in numerous experimental studies [7]. Increased circulating LPS and LBP concentrations have been found in patients with obesity [2,8].…”

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confidence: 99%

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

Guan

et al. 2019

Endocr J

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Obesity is linked to a low-grade systemic inflammation and lipopolysaccharide (LPS) is a key factor. Sleeve gastrectomy (SG) can significantly cause weight loss, but few reports have looked into the changes of LPS and inflammatory cytokines after surgery. To explore the potential short-term impact of SG on LPS and inflammatory cytokines and their relationship to early metabolic changes in obesity. 30 Chinese adults with obesity (BMI 39.37 ± 8.22 kg/m 2 , 25 female) receiving SG were included in this study. Fasting blood samples were collected at baseline and 30 days after SG. Serum LPS markedly reduced from 336.50 (73.54, 500) pg/mL to 5.00 (5.00, 5.24) pg/mL at 1 month after SG (p < 0.05). There was a significant decrease in plasma IL-6, IL-8, and serum CRP after SG (all p < 0.05). Insulin resistance improved remarkably after surgery as displayed by reductions in fasting insulin level (FINS, p < 0.001), and HOMA-IR (p < 0.001). In addition, visceral fat area (VFA) decreased from 209.70 ± 39.96 cm 2 to 193.28 ± 43.68 cm 2 after SG (p < 0.001). LPS was positively correlated with FINS (r = 0.391, p = 0.033) and HOMA-IR (r = 0.38, p = 0.038) before SG. Meanwhile, VFA was positively associated with CRP (r = 0.388, p = 0.034) before surgery. When assessing 30-days postoperative changes, a positive correlation was found between the variations of LPS, IL-8 and the reduction of VFA. After multivariate analyses, only the reduced IL-8 level was independently associated with the reduction of VFA (p = 0.015). In conclusion, SG can significantly relieve the inflammation in obesity in the short term and LPS might be an earlier predictor of inflammatory changes after surgery.

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Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity

Cited by 49 publications

References 46 publications

Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on TLR4, NF-κB and IRF3 Expression in Young Overweight and Obese Girls

Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

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