Short-term Electrical Stimulation Impacts Cardiac Cell Structure and Function
Kristen Allen,
Abigail Bandl,
Natalie Pachter
et al.
Abstract:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) are used to model cardiac development and disease. This requires a robust population of mature CMs and external stimuli to mimic the complex environment of the heart. In effort toward this maturation, previous groups have applied electrical stimulation (ES) to CMs with varying results depending on the stimulation duration, frequency, and pattern. As such, there is uncertainty surrounding the timeline on which stimulated iPSC-CMs begin to show earl… Show more
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