Short term effects of Zn in cholinergic SN56 neuroblastoma cells

Ronowska, Anna; Dyś, Aleksandra; Gul-Hinc, Sylwia; Jankowska-Kulawy, Agnieszka; Bielarczyk, Hanna; Szutowicz, Andrzej

doi:10.1016/s1734-1140(09)70205-1

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2022

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“…These observations are consistent with the notion that Zn 2+ electrostatically binds with negatively charged phospholipids and consequently leads to extensive reordering of the bilayer. 24,27,49,[56][57][58] Similar phenomena have been observed when incorporating peptides into PS-containing vesicles. 59 Moreover, upon addition to SLBs, Zn 2+ may readily bind with the PS in the upper leaflet of the bilayer and thus introduce an asymmetry in the membrane.…”

Section: Resultsmentioning

confidence: 70%

“…These observations are consistent with the notion that Zn 2+ could induce cell malformation and apoptotic and therefore be toxic to neurons and astrocytes. [49][50][51] Indeed, deformation of membranes can have remarkable effects on the function of membrane-anchored target proteins, which may account for physiological function of Zn 2+ involved in the regulation of several cellular processes.…”

Section: Fluorescence Microscopymentioning

confidence: 99%

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