Short-term effects of weather and air pollution on atopic dermatitis symptoms in children: A panel study in Korea

Kim, Young‐Min; Kim, Jihyun; Han, Youngshin; Jeon, Byoung-Hak; Cheong, Hae-Kwan; Ahn, Kangmo

doi:10.1371/journal.pone.0175229

Cited by 70 publications

(98 citation statements)

References 48 publications

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“…Air pollutants were found to have harmful effects on AD in our study, which was consistent with previous studies . We compared our results with a very similar study done in Chengdu, south‐western China .…”

Section: Discussionsupporting

confidence: 92%

“…A similar study in Shanghai, China also found the strongest effects between air pollutants and outpatient visits for eczema at lag0 . A panel study in Korea found an increase in PM 10 and NO 2 by 10 units increased the risk of eczema symptoms on the same day by 3.2% (95% CI: 1.5%, 4.9%) and 5.0% (95% CI: 1.4%, 8.8%), respectively . Our results, combined with the above previous studies, suggested that AD symptoms worsen and then people go to a clinic immediately.…”

Section: Discussionsupporting

confidence: 79%

“…The similar study in Chengdu, China found the greatest effects of air pollution at lag1 . The above panel study in Korea found the effects of PM10 were the greatest at lag0–5 (moving averages of 5 days) while the effects of NO 2 were the greatest at lag0 . The lag periods between exposure to air pollution and exacerbation of AD and between exacerbation and visiting a doctor were influenced by lots of factors.…”

Section: Discussionmentioning

confidence: 69%

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The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time‐series analysis

Guo

Xiong

Liang

et al. 2019

Acad Dermatol Venereol

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Background The prevalence of atopic dermatitis (AD) dramatically increased over these years and environmental factors were considered as potential contributors towards these trends. Objective This study aimed to explore several major environmental exposures, including air pollution, temperature and relative humidity, in order to identify potential modifiable risk factors and their interactive effects on AD. Methods We applied a bivariate response surface model and stratification model based on time‐series Poisson generalized additive models to examine the interactive effects of air pollution and meteorological factors on AD. Results A total of 64 987 outpatient visits for AD were recorded from 1 January 2013 to 31 December 2017. Interactive effects were found between air pollutants and meteorological factors. Enhanced positive associations between pollutants and outpatient visits for AD were found at the highest quartile temperature level. A 10 μg/m3 increase in PM2.5, PM10, NO2 and SO2 were associated with 0.42% (95% CI: 0.16–0.67%), 0.34% (95% CI: 0.15–0.54%), 1.11% (95% CI: 0.38–1.84%) and 1.06% (0.21–1.93%) increase in outpatient visits for AD at the highest quartile temperature level. Conclusion That effects of air pollutants on AD can be modified by meteorological factors, with enhanced effects on hot days.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 69%

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The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time‐series analysis

Guo

Xiong

Liang

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

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“…The model was adjusted for confounding factors, such as age, sex, season, SCORAD at the initial visit, and fever. Result of this analysis was presented in our previous report …”

Section: Methodsmentioning

confidence: 99%

“…Air pollutants are risk factors of allergic diseases, such as asthma and atopic dermatitis (AD) . In our previous studies, we elucidated that several indoor and outdoor air pollutants, such as particulate matter of <10 μm diameter (PM 10 ) and total volatile organic compounds, were associated with worsening of AD symptoms. These air pollutants appear to induce barrier dysfunction and/or immune dysregulation in the skin; which might be mediated by oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

Spectrum of susceptibility to air quality and weather in individual children with atopic dermatitis

Noh

Kim

et al. 2018

Pediatric Allergy Immunology

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Background Exposure to air pollution aggravates symptoms of atopic dermatitis (AD) in children in the population studies. Variability in individual patient's response from individual susceptibility is needed to be explored. Objective This study aimed to investigate spectrum of individual variability in the associations between AD symptoms and air quality. Methods We enrolled 89 children aged 0‐6 years with AD (22 890 person‐days). Daily manifestation of symptoms was recorded for an average of 257 days (range 100‐499). Both an individual analysis using logistic regression models and an overall analysis using a generalized estimating equation were performed. Results The odds ratios of an individual ranged 0.24‐8.11 for particulate matter <10 μm in diameter (PM10), 0.09‐101.92 for nitrogen oxide (NO2), 0.03‐44.00 for ozone (O3), 0.11‐58.30 for sulfur dioxide (SO2), 0.00‐15.83 for carbon monoxide (CO), 0.00‐39 446.94 for temperature, and 0.03‐5.18 for relative humidity, demonstrating a wide individual variability. In the overall analysis, PM10, NO2, SO2, and CO had a significantly positive association, whereas temperature and relative humidity were negatively associated with AD symptoms. Air pollution was responsible for aggravation of symptoms from 24.7% (O3) to 39.3% (SO2) of AD children. Overall, 71.9% of the AD children responded to at least one or more air pollution and weather variable. Conclusion Responses of AD children to air pollution and weather variable were considerably variable among individuals. An individualized model would be useful to forecast and manage AD symptoms in patients.

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Impact of environmental factors in predicting daily severity scores of atopic dermatitis

Hurault

Delorieux

Kim

et al. 2021

Clinical & Translational All

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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 20% of children worldwide. Environmental factors including weather and air pollutants have been shown to be associated with AD symptoms. However, the time-dependent nature of such a relationship has not been adequately investigated. This paper aims to assess whether real-time data on weather and air pollutants can make short-term prediction of AD severity scores.Methods: Using longitudinal data from a published panel study of 177 paediatric patients followed up daily for 17 months, we developed a statistical machine learning model to predict daily AD severity scores for individual study participants.Exposures consisted of daily meteorological variables and concentrations of air pollutants, and outcomes were daily recordings of scores for six AD signs. We developed a mixed-effect autoregressive ordinal logistic regression model, validated it in a forward-chaining setting and evaluated the effects of the environmental factors on the predictive performance.Results: Our model successfully made daily prediction of the AD severity scores, and the predictive performance was not improved by the addition of measured environmental factors. Potential short-term influence of environmental exposures on daily AD severity scores was outweighed by the underlying persistence of preceding scores.Conclusions: Our data does not offer enough evidence to support a claim that weather or air pollutants can make short-term prediction of AD signs. Inferences about the magnitude of the effect of environmental factors on AD severity scores require consideration of their time-dependent dynamic nature.

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Short-term effects of weather and air pollution on atopic dermatitis symptoms in children: A panel study in Korea

Cited by 70 publications

References 48 publications

The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time‐series analysis

The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time‐series analysis

Spectrum of susceptibility to air quality and weather in individual children with atopic dermatitis

Impact of environmental factors in predicting daily severity scores of atopic dermatitis

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