Short-Term Effects of “Polish Smog” on Cardiovascular Mortality in the Green Lungs of Poland: A Case-Crossover Study with 4,500,000 Person-Years (PL-PARTICLES Study)

Kuźma, Łukasz; Kurasz, Anna; Dąbrowski, Emil Julian; Dobrzycki, Sławomir; Bachórzewska−Gajewska, Hanna

doi:10.3390/atmos12101270

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…Podlaskie Voivodeship, Poland, is an ecological region, predominantly agricultural, with minimal industrialization and no significant heavy industry. Thus, the primary sources of heavy metal exposure are contaminated food due to pollution, and tobacco smoking [ 6 , 7 ]. Cd and Pb are significant environmental pollutants in Podlaskie Voivodeship, due to their prevalence, despite having relatively low concentrations [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

et al. 2023

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Background: Cadmium (Cd) and lead (Pb) are known to be two of the metal contaminants that pose the greatest potential threat to human health. The purpose of this research study was to compare the levels of toxic metals (Cd, Pb) in patients with acute ischemic stroke (AIS), with a control group in Podlaskie Voivodeship, Poland. The study also aimed to assess the correlations between toxic metals and clinical data in AIS patients, and to assess the potential effect of smoking. Materials and methods: The levels of mineral components in the collected blood samples were assessed by means of atomic absorption spectrometry (AAS). Results: The Cd blood concentration was significantly higher in AIS patients as compared to the control group. We found that the molar ratios of Cd/Zn and Cd/Pb were significantly higher (p < 0.001; p < 0.001, respectively), when the molar ratios of Se/Pb, Se/Cd, and Cu/Cd were significantly lower (p = 0.01; p < 0.001; p < 0.001, respectively), in AIS patients as compared to control subjects. However, there were no considerable fluctuations in relation to the blood Pb concentration or molar ratios of Zn/Pb and Cu/Pb between our AIS patients and the control group. We also found that patients with internal carotid artery (ICA) atherosclerosis, particularly those with 20–50% ICA stenosis, had higher concentrations of Cd and Cd/Zn, but lower Cu/Cd and Se/Cd molar ratios. In the course of our analysis, we observed that current smokers among AIS patients had significantly higher blood-Cd concentrations, Cd/Zn and Cd/Pb molar ratios, and hemoglobin levels, but significantly lower HDL-C concentrations, Se/Cd, and Cu/Cd molar ratios. Conclusions: Our research has shown that the disruption of the metal balance plays a crucial role in the pathogenesis of AIS. Furthermore, our results broaden those of previous studies on the exposure to Cd and Pb as risk factors for AIS. Further investigations are necessary to examine the probable mechanisms of Cd and Pb in the onset of ischemic stroke. The Cd/Zn molar ratio may be a useful biomarker of atherosclerosis in AIS patients. An accurate assessment of changes in the molar ratios of essential and toxic trace elements could serve as a valuable indicator of the nutritional status and levels of oxidative stress in AIS patients. It is critical to investigate the potential role of exposure to metal mixtures in AIS, due to its public health implications.

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Section: Introductionmentioning

confidence: 99%

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

et al. 2023

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Low-cost sensors and Machine Learning aid in identifying environmental factors affecting particulate matter emitted by household heating

Hassani,

Bykuć,

Schneider

et al. 2023

Atmospheric Environment

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Evaluation of the impacts of occupational exposure to PM and PAH on cardiovascular problems in wastewater treatment plant workers

Saad-Hussein

Beshir

Shaheen

et al. 2023

Preprint

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Background Workers in wastewater treatment plant (WWTPs) are at high risk of developing various infections and cardiovascular diseases (CVD). Aims of the study were estimation of the concentrations of 16 EPA priority polycyclic aromatic hydrocarbons (PAHs) and particulate matters (PM) with different sizes in air of WWTP, and prediction of CVDs to evaluate the potential risk of developing CVDs in the WWTP workers due to their occupational exposures, in addition to identification of the CVDs` risky work tasks. Methodology: PM concentrations, and wind rose plots for meteorological data, were monitored for 24 months. Estimation of the individual PAHs in suspended particulate matter samples and identification of sources were done. Cross-sectional study was done on 142 male workers from WWTP. All participants were subjected to occupational and medical questionnaire, electrocardiogram (ECG), and measurement of blood pressure. Serum APO-A, APO-B, APO-E, and Lipoprotein α (Lpα) were estimated for all participants. Results The annual mean concentrations of PM (PM1, PM2.5, PM10 and TSP) were lower than Egyptian limit. EPA 16 PAHs were detected in all samples, lower molecular weight PAHs were the most predominant PAHs. The most predominant wind direction was from North-West; as the selected WWPT is placed downwind to the surrounding areas. Fifty percent of the workers were complaining of dyspnea. About 30.9% of the workers were found to be hypertensive; the majority of them were from the operator department. ECG abnormalities were found in 18.3% of the workers mainly among operators (23.95%). Ventricular extra systole was the highest prevalent detected ECG abnormality followed by left ventricular enlargement. APO-B and APO-B/APO-A ratio were significantly higher in operator workers compared to the administrators and laboratory workers. While, APO-E was significantly lower in operator workers compared to the administrators and laboratory workers. Conclusion PM2.5 and PM1 and PAH exposure maybe associated with potential risk of developing CVD in the exposed WWTP workers. The main sources of PAHs in the WWTP could be the fuel used for the machines in the operator department, as the treatment process occurs in the WWTP contribute to high concentrations of PM and its PAHs, but the most contributed sources were found to be from the surrounding areas. The use of APO-B or APO-B/APO-A holds a promising biomarkers for evaluating cardiovascular disease risk.

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Short-Term Effects of “Polish Smog” on Cardiovascular Mortality in the Green Lungs of Poland: A Case-Crossover Study with 4,500,000 Person-Years (PL-PARTICLES Study)

Cited by 5 publications

References 42 publications

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

Low-cost sensors and Machine Learning aid in identifying environmental factors affecting particulate matter emitted by household heating

Evaluation of the impacts of occupational exposure to PM and PAH on cardiovascular problems in wastewater treatment plant workers

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