Short-term effects of losartan on autonomic nervous system

Capria, A.; Antonucci, F.; Ciamei, Angela; Roncoroni, V.; Sabino, D; Fontana, Luigi

doi:10.1016/s0895-7061(00)00636-1

Cited by 1 publication

(3 citation statements)

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“…It was observed that HRV was significantly increased after 3 months in losartan groups but though increased but not significant in amlodipine treated patients. For losartan, similar observation was made by Carpia et al 25 and Chern et al 20 whereas others did not find this effect. For amlodipine, results of this study were almost similar to other investigators but they studied this effect with less duration of treatment.…”

Section: Discussionsupporting

confidence: 77%

“…Similar investigations found relative improvement of HRV after few weeks of treatment with both the drugs but it was still remained lower than the controls. [25][26][27] In this study, time domain result reflct lower cardiac vagal modulation in untreated patients which was found significantly improved with both drugs after 3 and 6 months treatment.On further analysis the effect of losartan was found more pronounced than amlodipine improving the cardiac vagal activity which is supported by significantly higher value of RMSSD and lower value of mean HR in losartan treated patients. In addition, 6 months duration of treatment was found more effective than 3 months treatment which is supported by the facts that HRV values were close to controls after 6 months treatment.…”

Section: Discussionsupporting

confidence: 54%

“…3,22 Literature review present conflicting reports on the effect of losartan and amlodipine on cardiac autonomic activity. Few studies reported losartan inhibit sympathetic activity in hypertensive patients but others found no significant effect [23][24][25] . Similar reports were also found about the effect of amlodipine.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Losartan and Amlodipine on Heart Rate Variability In Essential Hypertensive Patients

Sultana

Begum

Ferdousi

et al. 2014

J Bangladesh Soc Physiol

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Background: Essential hypertension is characterized by sympathovagal imbalance that is responsible for arrhythmias and sudden cardiac death. Antihypertensive drugs restores sympatho vagal balance. Losartan and amlodipine are common antihypertensive drugs. Objective: To compare the effect of losartan and amlodipine on heart rate variability (HRV) in hypertensive patients . Methods: This prospective analytical study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2012 to June 2013. For this study, 120 newly diagnosed hypertensive patients without any treatment (group B, age 30-55 years) were selected from the Out Patients Department of cardiology, BSMMU, Dhaka on their first day of visit. 60 apparently healthy normotensive subjects were also studied as control (group A). HRV of the patients were measured both before and after they were treated with two different antihypertensive drugs (losartan and amlodipine) separately. According to the selection of drug these patients were divided into two groups. Group B1 included 60 patients received losartan 50 mg daily and group B2 included 60 patients treated by amlodipine 5 mg daily. They were observed once before the treatment (B1 a &B2 a) and after3 months medication(B1 b & B2 b ) and also after 6 months medication (B1 c & B2 c ). For assessing HRV, Mean heart rate (HR),Mean R-R interval, Max/Min R-R interval, SDNN, RMSSD were recorded by a polyrite. Data were compared among before treatment, after 3 months treatment and after 6 months treatment. For statistical analysis ANOVA, independent sample't' test and paired sample 't' were performed. Results: Mean resting pulse rate, mean heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly higher(P<0.001) and mean R-R interval, SDNN, RMSSD were significantly lower(P<0.001) in patients before treatment compared to those of healthy normotensive subjects and to the values after treatment. In both drug groups, SDNN, RMSSD,mean R-R interval were found significantly higher after 6 months of treatment compared to their values after 3 months treatment and also close to the values in normotensive subjects. In losartan group RMSSD were found significantly higher (p<0.01) and mean R-R interval,SDNN were found though higher but not significant than the corresponding values in amlodipine treated patients after 6 months treatment. Conclusion: Vagal modulation is decreased in untreated hypertensive patients which is increased by treatment with both losartan and amlodipine but the effect is more pronounced in losartan. The decreased autonomic function was improved better with longer treatment duration.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 54%