Short-term effects of fine particulate matter pollution on daily health events in Latin America: a systematic review and meta-analysis

Fajersztajn, Laís; Saldiva, Paulo Hilário Nascimento; Pereira, Luiz Alberto Amador; Leite, Victor Figueiredo; Buehler, Anna Maria

doi:10.1007/s00038-017-0960-y

Cited by 78 publications

(54 citation statements)

References 32 publications

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“…An increase of 10μg/m 3 in daily concentrations of PM 2.5 was significantly associated with increased risk of respiratory mortality in all age brackets (RR = 1.02, 95%CI: 1.02-1.02), and the authors concluded that short-term exposure to PM 2.5 in Latin American cities is significantly associated with increased risk of respiratory mortality. The review also shows that there are still few studies on fine particulate matter 23 .…”

Section: Discussionmentioning

confidence: 97%

“…In a review of 1,628 studies in Latin American cities 23 , nine were selected for the qualitative analysis and seven for the quantitative analyses. An increase of 10μg/m 3 in daily concentrations of PM 2.5 was significantly associated with increased risk of respiratory mortality in all age brackets (RR = 1.02, 95%CI: 1.02-1.02), and the authors concluded that short-term exposure to PM 2.5 in Latin American cities is significantly associated with increased risk of respiratory mortality.…”

Section: Discussionmentioning

confidence: 99%

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Efeitos da exposição a poluentes do ar na saúde das crianças de Cuiabá, Mato Grosso, Brasil

Machín

Nascimento

2018

Cad. Saúde Pública

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Efeitos da exposição a poluentes do ar na saúde das crianças de Cuiabá, Mato Grosso, Brasil

Machín

Nascimento

2018

Cad. Saúde Pública

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“…Consequently, air pollution and its effects on health are considered to be a public health problem. Nevertheless, very few studies have been conducted in Latin America on the effects of air pollution on health, particularly with regard to morbidity [9]. …”

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Air Pollution on Respiratory and Circulatory Morbidity in Colombia 2011–2014: A Multi-City, Time-Series Analysis

Rodríguez-Villamizar

Rojas

Becerra

et al. 2018

IJERPH

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Few studies have been conducted on the effect of air pollution on morbidity in Latin America. This study analyzed the effects of air pollution on respiratory and circulatory morbidity in four major cities in Colombia. An ecological time-series analysis was conducted with pollution data from air quality monitoring networks and information on emergency department visits between 2011 and 2014. Daily 24-h averages were calculated for NO2, PM10, PM2.5, and SO2 as well as 8-h averages for CO and O3. Separate time-series were constructed by disease group and pollutant. Conditional negative binomial regression models were used with average population effects. Effects were calculated for the same day and were adjusted for weather conditions, age groups, and their interactions. The results showed that effects of some of the pollutants differed among the cities. For NO2, PM10, and PM2.5, the multi-city models showed greater and statistically significant percentage increases in emergency department visits for respiratory diseases, particularly for the 5 to 9-year-old age group. These same pollutants also significantly affected the rate of emergency department visits for circulatory diseases, especially for the group of persons over 60 years of age.

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“…In aerodynamic terms, fine particulate matter ≤2.5 μm (PM2.5) in diameter has been held responsible for being the major air pollutant. Pulmonary diseases including lung cancer, chronic obstructive pulmonary disease and allergic asthma have been found to be caused by exposure to PM2.5, resulting in considerable morbidity and mortality (Fajersztajn, Saldiva, Pereira, Leite, & Buehler, ; Raaschou‐Nielsen et al, ; Xing, Xu, Shi, & Lian, ). Children, the elderly and individuals with pre‐existing pulmonary disease are particularly vulnerable (Anderson, Atkinson, Bremner, & Marston, ; Mathieu‐Nolf, ).…”

Section: Introductionmentioning

confidence: 99%

Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation

Zhao

Guo

Zhang

et al. 2017

J of Applied Toxicology

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Upper airway diseases including sinonasal disorders may be caused by exposure to fine particulate matter (≤2.5 μm; PM2.5), as proven by epidemiological studies. PM2.5 is a complex entity whose chemical constituents and physicochemical properties are not confined to a single, independent "particle" but which in this study means a distinctive environmental "toxin." The mechanism whereby PM2.5 induces nasal epithelial barrier dysfunction leading to sinonasal pathology remains unknown. In the present study, human nasal epithelial cells were exposed to non-cytotoxic doses of PM2.5 to examine how PM2.5 affects the nasal epithelial barrier. Tight junction (TJ) integrity and function were assessed by transepithelial electric resistance and paracellular permeability. The expression levels of TJ proteins such as zona occludens-1, occludin and claudin-1 were assessed by immunofluorescence staining and western blot. PM2.5 exposure induced epithelial barrier dysfunction as reflected by increased paracellular permeability and decreased transepithelial electric resistance. TJ proteins zona occludens-1, occludin and claudin-1 were found to be downregulated. Pretreatment with N-acetyl-l-cysteine alleviated PM2.5-mediated reactive oxygen species generation in RPMI 2650 cells, further preventing barrier dysfunction and attenuating the degradation of TJ proteins. These results suggest that PM2.5 induces nasal epithelial barrier disruption via oxidative stress, and N-acetyl-l-cysteine counteracts this PM2.5-mediated effect. Thus, nasal epithelial barrier disruption caused by PM2.5, which leads to sinonasal disease, may be prevented or treated through the inhibition of reactive oxygen species.

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Short-term effects of fine particulate matter pollution on daily health events in Latin America: a systematic review and meta-analysis

Cited by 78 publications

References 32 publications

Efeitos da exposição a poluentes do ar na saúde das crianças de Cuiabá, Mato Grosso, Brasil

Efeitos da exposição a poluentes do ar na saúde das crianças de Cuiabá, Mato Grosso, Brasil

Short-Term Effects of Air Pollution on Respiratory and Circulatory Morbidity in Colombia 2011–2014: A Multi-City, Time-Series Analysis

Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation

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