Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats

Zhang, Yemao; Liu, Xingfa; Zhang, Jiangong; Li, Ni

doi:10.3109/09553002.2014.954058

Cited by 28 publications

(13 citation statements)

References 40 publications

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“…Morris water maze was first reported in 1984 (Morris, 1984), and subsequently became one of the most frequently used laboratory tools in behavioral neuroscience. In previous study, our group had shown that 100 mT ELF-EMF exposure for 12 weeks did not affect the spatial learning in MWM (Zhang et al, 2015b). In the present study, similar results were observed even though the exposure time was prolonged to 24 weeks.…”

Section: Discussionsupporting

confidence: 90%

“…Our previous work has shown that short term ELF-EMF exposure did not affect learning and memory as assessed by Morris water maze (Zhang et al, 2015b). In the present study, we employed adult male rats to investigate whether the exposure to ELF-EMF (50 Hz, 100 mT) would influence behavior, including anxiety-like behavior, depression-like behavior, spatial learning, fear learning and memory using more comprehensive measurements.…”

Section: Introductionmentioning

confidence: 93%

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Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

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Recently, extremely low frequency electromagnetic fields (ELF-EMF) have received considerable attentions for their potential pathogenicity. In the present study, we explored the effects of ELF-EMF on behaviors of adult male rats. Sixty adult male rats were randomly divided into two groups, the sham exposure group and the 50Hz/100μT ELF-EMF exposure group. During the 24 weeks exposure, body weight, as well as food and water intake were recorded. Results showed that food and water intake and the body weight of the rats were not affected by the exposure. After 24 weeks exposure, open field test and elevated plus maze were conducted to evaluate the anxiety-like behavior, the tail suspension test and forced swim test were conducted to evaluate depression-like behavior and Morris water maze and fear conditioning tests were used to evaluate the cognitive and memory ability. Exposure to ELF-EMF did not induce any anxiety-like or depression-like behaviors compared with the sham exposure. Moreover, the cognitive and memory ability was not impaired by the ELF-EMF exposure. Furthermore, ELF-EMF exposure did not affect the morphology and histology of the brain. In conclusion, 24 weeks exposure to 50Hz/100μT ELF-EMF had no effect on the behaviors of the adult male rats.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 93%

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

Self Cite

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“…Sensitivities for IL-9, IL-10, and TNF-α assay were 0.53, 1.51, and 2.51 pg/ mL, respectively. 4,29 Statistical Analysis…”

Section: Cytokines Assaymentioning

confidence: 99%

“…1 Some studies have indicated that exposure to ELF-EMFs has possible health hazards such as cancer, leukemia, neurodegenerative diseases, and infertility. [2][3][4][5] Despite potential negative impacts of ELF-EMFs, nowadays, they can effectively be used to diagnose and treat various diseases such as cancer, muscle regeneration, diabetes, arthritis, and neurological disorders. 1,6 These disorders can be caused by abnormal immune response to harmful invaders.…”

mentioning

confidence: 99%

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Mahaki

Jabarivasal

Sardanian

et al. 2020

Int J Occup Environ Med

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Background: Extremely low-frequency electromagnetic fields (ELF-EMFs) are abundantly produced in modern societies. In recent years, interest in the possible effects of ELF-EMFs on the immune system has progressively increased. Objective: To examine the effects of ELF-EMFs with magnetic flux densities of 1, 100, 500, and 2000 µT on the serum levels of interleukin (IL)-9, IL-10, and tumor necrosis factor-alpha (TNF-α). Methods: 80 adult male rats were exposed to ELF-EMFs at a frequency of 50 Hz for 2 h/day for 60 days. The serum cytokines were measured at two phases of pre- and post-stimulation of the immune system by human serum albumin (HSA). Results: Serum levels of IL-9 and TNF-α, as pro-inflammatory cytokines, were decreased due to 50 Hz EMFs exposure compared with the controls in the pre- and post-stimulation phases. On the contrary, exposures to 1 and 100 µT 50 Hz EMFs increased the levels of antiinflammatory cytokine, and IL-10 only in the pre-stimulation phase. In the post-stimulation phase, the mean level of serum IL-10 was not changed in the experimental groups. Conclusion: The magnetic flux densities of 1 and 100 µT 50 Hz EMFs had more immunological effects than EMFs with higher densities. Exposure to 50 Hz EMFs may activate anti-inflammatory effects in rats, by down-modulation of pro-inflammatory cytokines (IL-9 and TNF-α) and induction of the anti-inflammatory cytokine (IL-10).

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“…(1993) and London et al (1991), suggest that the relationship was not proven. Several studies (Kumar et al, 2013;Hancı et al, 2013;Hao et al, 2013;Zhang, Liu, Zhang, & Li, 2015) using experimental animals have also been conducted since the sixties and the results are still varied, ranging from no-effect images, no effect on behavioral changes until the occurrence of defects in the offspring. Although the results of examination of the effect of electromagnetic exposures on animal indicate the presence of adverse effects, such exposures effect does not prove harmful in residential, working environments and human health (World Health Organisation [WHO], 1987).…”

Section: Literature Reviewmentioning

confidence: 99%

Electromagnetic Fields Exposure From Extra High Voltage Transmission On Public Health: A Case-Control Study in Three Districts In Central Java

Anies¹,

Sasongko²,

Setyowati³

2018

GJHS

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This study is to prove the effect of electromagnetic field exposure from 500 kV Extra High Voltage Transmission to the incidence of electrical sensitivity and the extent of the risk of electrical sensitivity incidence on the population residing in areas/in the proximity of 500 kV transmission facilities compared to residents who do not live under it. The study design employed is the case-control observational analytic epidemiology, and qualitative study, with 249 samples, consisted of 83 cases and 166 controls. The study was conducted in Pekalongan municipality, Pemalang municipality and Tegal municipality, all in Central Java. The results show that there are some effects of the electromagnetic field 500 kV electricity transmission exposure with the incidence of electrical sensitivity. Moreover, the electrical sensitivity incidence on the residents living under 500 kV electricity transmission is 5.8 times compared to those who do not live under 500 kV electricity transmission.

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Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats

Cited by 28 publications

References 40 publications

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Electromagnetic Fields Exposure From Extra High Voltage Transmission On Public Health: A Case-Control Study in Three Districts In Central Java

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