Short-term effects of ambient fine particulate matter pollution on hospital visits for chronic obstructive pulmonary disease in Beijing, China

Tian, Yaohua; Xiao, Xiang; Juan, Juan; Song, Jing; Cao, Yaying; Huang, Chao; Li, Man; Hu, Yonghua

doi:10.1186/s12940-018-0369-y

Cited by 62 publications

(47 citation statements)

References 46 publications

(66 reference statements)

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“…We obtained data on CHF hospitalization from Beijing Medical Claim Data for Employees, which covers all working and retired employees. Sex, date of birth, dates of hospital visits, medication use, discharge diagnoses in Chinese, and corresponding International Classification of Diseases 10th version (ICD-10) codes are all contained in this database, the details of which have been described previously [ 13 ]. In the present study, the primary study cohort included only adults.…”

Section: Methodsmentioning

confidence: 99%

“…According to Xie et al [ 12 ], in all high-density population areas (>5000 people/km 2 ), 97.8% (44/45) of the tertiary hospitals and 79.3% (69/87) of the secondary hospitals in Beijing are located within a 40-km radius of the monitor. Additionally, the application and reliability of the US embassy’s monitoring point data has been discussed in previous studies [ 13 , 16 ]. Until 2013, China has gradually introduced PM 2.5 in the national air quality monitoring network and publicized real-time monitoring data.…”

Section: Methodsmentioning

confidence: 99%

“…We have also conducted stratified analyses to explore the potential confounding effects of age and sex. To test the robustness of results, we also conducted sensitivity analyses in terms of df values for time trend (4–8 per year), temperature (2–6), and relative humidity (2–6) [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

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Association Between PM2.5 and Daily Hospital Admissions for Heart Failure: A Time-Series Analysis in Beijing

Tian

et al. 2018

IJERPH

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There is little evidence that acute exposure to fine particulate matter (PM2.5) impacts the rate of hospitalization for congestive heart failure (CHF) in developing countries. The primary purpose of the present retrospective study was to evaluate the short-term association between ambient PM2.5 and hospitalization for CHF in Beijing, China. A total of 15,256 hospital admissions for CHF from January 2010 to June 2012 were identified from Beijing Medical Claim Data for Employees and a time-series design with generalized additive Poisson model was used to assess the obtained data. We found a clear significant exposure response association between PM2.5 and the number of hospitalizations for CHF. Increasing PM2.5 daily concentrations by 10 μg/m3 caused a 0.35% (95% CI, 0.06–0.64%) increase in the number of CHF admissions on the same day. We also found that female and older patients were more susceptible to PM2.5. These associations remained significant in sensitivity analyses involving changing the degrees of freedom of calendar time, temperature, and relative humidity. PM2.5 was associated with significantly increased risk of hospitalization for CHF in this citywide study. These findings may contribute to the limited scientific evidence about the acute impacts of PM2.5 on CHF in China.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Association Between PM2.5 and Daily Hospital Admissions for Heart Failure: A Time-Series Analysis in Beijing

Tian

et al. 2018

IJERPH

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“…Industrialization and urbanization have caused air pollution issues in China; these issues have challenged public health and posed a substantial economic burden [1,2]. Many epidemiological studies have illustrated that air pollution exposure is correlated with an increased risk of hospitalization and mortality in individuals with chronic obstructive pulmonary disease (COPD) [3][4][5], which is characterized by irreversible airflow limitation and has a high prevalence in China [6,7]. As a noninvasive and readily available test, spirometry is the most reproducible and objective measurement tool to diagnose COPD and assess disease severity in any healthcare setting.…”

Section: Introductionmentioning

confidence: 99%

Lung function and systemic inflammation associated with short-term air pollution exposure in chronic obstructive pulmonary disease patients in Beijing, China

Gao

et al. 2020

Environ Health

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Background: Exposure to air pollution is associated with chronic obstructive pulmonary disease (COPD). However, findings on the effects of air pollution on lung function and systemic inflammation in Chinese COPD patients are inconsistent and scarce. This study aims to evaluate the effects of ambient air pollution on lung function parameters and serum cytokine levels in a COPD cohort in Beijing, China. Methods: We enrolled COPD participants on a rolling basis from December 2015 to September 2017 in Beijing, China. Follow-ups were performed every 3 months for each participant. Serum levels of 20 cytokines were detected every 6 months. Hourly ambient pollutant levels over the same periods were obtained from 35 monitoring stations across Beijing. Geocoded residential addresses of the participants were used to estimate daily mean pollution exposures. A linear mixed-effect model was applied to explore the effects of air pollutants on health in the first-year of follow-up. Results: A total of 84 COPD patients were enrolled at baseline. Of those, 75 COPD patients completed the first-year of follow-up. We found adverse cumulative effects of particulate matter less than 2.5 μm in aerodynamic diameter (PM 2.5), nitrogen dioxide (NO 2), sulfur dioxide (SO 2) and carbon monoxide (CO) on the forced vital capacity % predicted (FVC % pred) in patients with COPD. Further analyses illustrated that among COPD patients, air pollution exposure was associated with reduced levels of serum eotaxin, interleukin 4 (IL-4) and IL-13 and was correlated with increased serum IL-2, IL-12, IL-17A, interferon γ (IFNγ), monocyte displacing protein 1 (MCP-1) and soluble CD40 ligand (sCD40L). Conclusion: Acute exposures to PM 2.5 , NO 2 , SO 2 and CO were associated with a reduction in FVC % pred in COPD patients. Furthermore, short-term exposure to air pollutants increased systemic inflammation in COPD patients; this may be attributed to increased Th1 and Th17 cytokines and decreased Th2 cytokines.

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“…PM pollution affects urban and regional air quality [5][6][7] and visibility [8][9][10], and even plays an important role in global climate change [11][12][13]. PM at high concentrations can significantly increase the incidence of human respiratory and cardiovascular diseases and mortality [14][15][16]. Because of the harm of PM pollution, people have drawn significant attention to it in recent years [17,18].…”

Section: Introductionmentioning

confidence: 99%

Temporal and Spatial Distribution Characteristics of Atmospheric Particulate Matter (PM10 and PM2.5) in Changchun and Analysis of Its Influencing Factors

Xie

Fang

2019

Atmosphere

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With Changchun’s economic development, atmospheric particulate pollution has become a significant challenge in Changchun. The spatiotemporal patterns of particulate matter emissions are an inherent characteristic for particulate matter emissions. By using hourly PM (particulate matter) mass concentration measured at 10 atmospheric automatic monitoring stations and meteorological parameters, the spatiotemporal distribution characteristics of particulate matter (PM10 and PM2.5) and its relationship with meteorological parameters of Changchun have been analyzed. Pollution pathways and source distribution were investigated using HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory) model and cluster analysis. Results indicated that the quarterly average PM2.5 and PM10 mass concentrations in Changchun were higher in the first quarter and the fourth quarter. PM concentrations observed in all seasons generally exhibited two peaks, at 07:00–10:00 and 21:00–23:00, with the exception of PM10 in spring. PM pollution was concentrated mainly in the central, northern, and western areas of Changchun in most seasons, mainly due to anthropogenic activities and soil dust transported outside the region. PM concentrations were negatively correlated with relative humidity and temperature. PM2.5 concentrations were negatively correlated with wind speed, while PM10 concentrations were positively correlated with wind speed. The results of backward trajectory clustered showed that the northwest airflow had the greatest impact on PM of Changchun, except summer.

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Short-term effects of ambient fine particulate matter pollution on hospital visits for chronic obstructive pulmonary disease in Beijing, China

Abstract: Background: Little is known about the effect of ambient fine particulate matter (PM 2.5 ) on chronic obstructive pulmonary disease (COPD) in China. The objective of this study was to explore the short-term effects of PM 2.5 on outpatient and inpatient visits for COPD in Beijing, China.

Cited by 62 publications

References 46 publications

Association Between PM2.5 and Daily Hospital Admissions for Heart Failure: A Time-Series Analysis in Beijing

Association Between PM2.5 and Daily Hospital Admissions for Heart Failure: A Time-Series Analysis in Beijing

Lung function and systemic inflammation associated with short-term air pollution exposure in chronic obstructive pulmonary disease patients in Beijing, China

Temporal and Spatial Distribution Characteristics of Atmospheric Particulate Matter (PM10 and PM2.5) in Changchun and Analysis of Its Influencing Factors

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