Short-term Effects of Acute Kidney Injury

Singbartl, Kai; Joannidis, Michael

doi:10.1016/j.ccc.2015.06.010

Cited by 54 publications

(40 citation statements)

References 92 publications

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“…There is a clear association between fluid overload and outcome but a causative link has not been confirmed [15] . In certain subgroups of patients, diuretics can be effective at preventing and correcting fluid overload (i.e., in patients with acute lung injury or congestive heart failure) [16] but RRT is often needed in critically ill patients with limited physiological reserve to tolerate fluid overload.…”

Section: When Should Acute Renal Replacement Therapy Be Initiated?mentioning

confidence: 99%

Patient Selection and Timing of Continuous Renal Replacement Therapy

et al. 2016

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When and in whom to initiate continuous renal replacement therapy (CRRT) for acute kidney injury (AKI) remains a highly controversial topic with large practice variation around the world. Even within countries, practice variation exists and recommendations for clinical practice are not specific. In this article, we report the consensus recommendations for timing and patient selection for CRRT - the results of the 2016 Acute Disease Quality Initiative XVII conference on ‘precision CRRT'. We suggest that these recommendations could serve to develop the best clinical practice and standards of care for use of CRRT in patients with AKI. Finally, we identify and highlight the areas of ongoing uncertainty and propose an agenda for future research.

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Section: When Should Acute Renal Replacement Therapy Be Initiated?mentioning

confidence: 99%

Patient Selection and Timing of Continuous Renal Replacement Therapy

et al. 2016

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“…AKI is a syndrome characterized by rapid deterioration of kidney function within several hours to several days, is a common disease in critically ill patients and is often diagnosed in the context of other acute illnesses (28). Among the primary causes of AKI are renal hypoxia and energy supply failure after kidney ischemia.…”

Section: Discussionmentioning

confidence: 99%

miR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha

Liu

Li²,

He³

et al. 2017

Mol Med

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The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1-α (HIF-1α) activation. ) is known to be induced by HIF-1α and can regulate various pathological processes, but its role in hypoxic kidney injury remains unclear. Here, in both rat systemic hypoxia and local kidney hypoxia models, we found miR-210 levels were upregulated significantly in injured kidney, especially in renal tubular cells. A similar increase was observed in hypoxia-treated human renal tubular HK-2 cells. We also verified that miR-210 can directly suppress HIF-1α expression by targeting the 3′ untranslated region of HIF-1α mRNA in HK-2 cells in severe hypoxia. Accordingly, miR-210 overexpression caused significant inhibition of the HIF-1α pathway and attenuated apoptosis caused by hypoxia, while miR-210 knockdown exerted the opposite effect. Taken together, our findings verify that miR-210 is involved in the molecular response in hypoxic kidney lesions in vivo and attenuates hypoxia-induced renal tubular cell apoptosis by targeting HIF-1α directly and suppressing HIF-1α pathway activation in vitro.

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“…Renal vasoconstriction occurs in the absence of reduced cardiac output and blood volume, which is in contrast to most clinical conditions associated with renal hypoperfusion. 18 There are 2 different forms of HRS described in the literature. 17 Although their pathophysiology is similar, their manifestations and outcomes are different.…”

Section: Hepato Renal Syndrome (Hrs)mentioning

confidence: 99%

Acute kidney injury in critically ill

Raveendran

2017

Sri Lankan J Anaesthesiol

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Acute kidney injury (AKI) is frequent in hospitalised critically ill patients with a high incidence in ICU patients. It is associated with increased mortality, greater cost, prolonged intensive care and hospital stay and progress to development of chronic kidney disease. AKI is an independent risk factor for increased mortality and severe morbidity. Sepsis is a leading cause of AKI in critically ill patients. The management is still supportive and early recognition, haemodynamic optimisation, avoidance of nephrotoxic medications, treatment of the underlying cause and renal replacement therapy are important. AKI is a preventable and outcome can be improved by early diagnosis and effective management. The aim of this review is to provide a comprehensive update on recent evidence in the field of AKI in critically ill patients, including risk factors, causes, pathophysiology, diagnosis/classification, prevention and management.

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Short-term Effects of Acute Kidney Injury

Cited by 54 publications

References 92 publications

Patient Selection and Timing of Continuous Renal Replacement Therapy

Patient Selection and Timing of Continuous Renal Replacement Therapy

miR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha

Acute kidney injury in critically ill

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