Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells

Park, Jiwoong; Lee, Myung-Won

doi:10.1186/s12886-018-0682-9

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…Consistent with the findings in previous studies, [10][11][12][13][14] the present study showed substantial IOP spikes at 5 minutes after IVI. However, these spikes were transient and the IOP reduced to <21 mmHg at 30 minutes in 83.3% of patients.…”

Section: Discussionsupporting

confidence: 93%

Predictors of elevated intraocular pressure after intravitreal injection of anti-vascular endothelial growth factor: a prospective observational study

Tsui

Lau

et al. 2021

Hong Kong Journal of Ophthalmology

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Section: Discussionsupporting

confidence: 93%

Predictors of elevated intraocular pressure after intravitreal injection of anti-vascular endothelial growth factor: a prospective observational study

Tsui

Lau

et al. 2021

Hong Kong Journal of Ophthalmology

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“…It has been established that IOP increases rapidly within a short time after intravitreal injection of drugs, and most IOP drops to the normal range 30 minutes later. For instance, study by Jiwoong Park's group showed that [19] the average IOPs of all patients at baseline, 2 min, 5 min, and 30 min after injection were 11.48 ± 2.22 mmHg, 49.71 ± 10.73 mmHg, 37.64 ± 11.68 mmHg, and 14.88 ± 4.77 mmHg respectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Repeated Intravitreal anti-Vascular Endothelial Growth Factor Drugs on Corneal Endothelium

Zhang

et al. 2023

Preprint

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Objective To investigate the potential effect of repeated intravitreal injection of anti-Vascular Endothelial Growth factor(anti-VEGF)drugs on corneal endothelium in patients with macular edema. Methods This is a prospective study in which a total of 64 patients (64 eyes) were treated with intravitreal injection of anti-VEGF. There were 19 cases of neovascular Age-Related Macular Degeneration (nAMD), 20 cases of Diabetic Macular Edema (DME)and 25 cases of Retinal Vein Occlusion (RVO). 29 cases were treated with Aflibercept (2mg/0.05ml) and 35 cases with Ranibizumab (0.5mg /0.05ml). 3 + PRN therapy was used. Corneal endothelial microscopy was used to measure the corneal thickness and corneal endothelium. The various changes in corneal thickness, corneal endothelial cell density, average cell area, coefficient of variation, and proportion of hexagonal cells were compared between one month after each injection and before injection. Results The proportion of corneal endothelial hexagonal cells (Hex%) in the operative eyes after the 2nd and 3rd injection was found to be significantly lower than that of baseline. Hex% in the operative eyes after the 4th injection was lower than that of baseline, 2nd as well 3rd injection and the difference was statistically significant (P < 0.05). The number of injections was irrelevant to the changes of corneal endothelium. There were no statistically significant differences in all corneal endothelial indexes in contralateral eye. Conclusion Repeated intravitreal anti-VEGF drugs can affect the morphology of corneal endothelial cells. Thus, for patients with fundus disease who need multiple intravitreal injection of anti-VEGF drugs, attention should be paid to the changes of corneal endothelium, especially for those suffering with diabetes, a history of eye surgery (such as cataract surgery), or patients with high intraocular pressure and other diseases that can adversely affecting corneal endothelium.

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“…Acute high intraocular pressure, one crucial pathological process in glaucoma, often results in retinal ganglion cell apoptosis and even necrosis, exacerbating optic nerve damage (9)(10)(11). Studies have unraveled that (12,13) inflammation and cell apoptosis are vital pathological reactions in acute high intraocular high pressure, and in acute high intraocular pressure injury, high intraocular pressure-induced vascular injury and other damage factors cause the increase in the release of local inflammatory factors and other cytokines in the optic nerve. Of them, inflammatory factors IL-6 and TNF-α can further activate several downstream signaling pathways to exert a crucial regulatory effect on cell apoptosis, abnormally raising the expression of apoptosis effector molecule Caspase-3 to mediate cell apoptosis.…”

Section: Content Of Il-6 and Tnf-α Determined Using Elisamentioning

confidence: 99%

Influences of Rapamycin on Retinal Ganglion Cells in Rats with Acute High Intraocular Pressure Through Regulating COX-2

Gao¹,

Fan²,

Wang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The study aimed to explore the influences of rapamycin on the retinal ganglion cells in rats with acute high intraocular pressure through regulating cyclooxygenase-2 (COX-2). 36 Sprague-Dawley rats were randomly assigned to the normal group (n=12), model group (n=12) and rapamycin group (n=12). The rats in the normal group were normally fed, those in the model group were prepared the model of acute high intraocular pressure and injected with normal saline, and those in the rapamycin group were given rapamycin. At 7 d after the operation, sampling was performed. The expressions of COX-2 and Caspase-3 were detected via immunohistochemistry, and their protein expressions were determined using Western blotting (WB). Quantitative polymerase chain reaction (qPCR) was conducted to measure the messenger ribonucleic acid (mRNA) expression levels, and cell apoptosis was evaluated using terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) assay. The content of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) was determined via enzyme-linked immunosorbent assay (ELISA). Compared with those in the normal group, the positive expression levels rose substantially in the other two groups, and those in the rapamycin group were notably lower (p<0.05). The relative protein expression levels in the model group and rapamycin group were higher, and the rapamycin group exhibited remarkable decreases (p<0.05). In comparison with the normal group, the other two groups had considerably raised relative mRNA expression levels and those in the rapamycin group were lower (p<0.05). The cells in the model and rapamycin groups had a higher apoptosis rate, and the apoptosis rate of cells in the rapamycin group was lower (p<0.05). Compared with that in the normal group, the content of IL-6 and TNF-α was elevated in the other two groups and their content in the rapamycin group was lower. Rapamycin inhibits COX-2 to repress inflammation and apoptosis, thereby exerting a protective effect on the retinal ganglion cells in rats with acute high intraocular pressure.

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Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells

Cited by 12 publications

References 26 publications

Predictors of elevated intraocular pressure after intravitreal injection of anti-vascular endothelial growth factor: a prospective observational study

Predictors of elevated intraocular pressure after intravitreal injection of anti-vascular endothelial growth factor: a prospective observational study

Effect of Repeated Intravitreal anti-Vascular Endothelial Growth Factor Drugs on Corneal Endothelium

Influences of Rapamycin on Retinal Ganglion Cells in Rats with Acute High Intraocular Pressure Through Regulating COX-2

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