Short-term effect of pitavastatin on the reactive hyperemic index in post-menopausal women with high levels in serum LDL-cholesterol

Nonogaki, Katsunori; Suzuki, Masatsugu; Kanai, Norifumi; Sumii, Makiko; Kaji, Takao

doi:10.1016/j.ijcard.2011.05.019

Cited by 2 publications

(1 citation statement)

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“…O’Driscoll et al demonstrated that 4-week simvastatin treatment improved FMD in subjects with dyslipidemia 5. A similar positive effect on microvascular function was recently confirmed by Nonogaki et al using RH-PAT 4 weeks after pitavastatin therapy 6. Tsunekawa et al reported that cerivastatin improved FMD within 3 days in subjects with diabetes, independent of its lipid lowering effect 7.…”

Section: Discussionmentioning

confidence: 83%

Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

Kono¹,

Fukuda²,

Shimada³

et al. 2013

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Background:It has been reported that pitavastatin improves endothelial function faster than other statins. Recently introduced reactive hyperemia peripheral arterial tonometry (RH-PAT) provides objective and quantitative assessment of peripheral microvascular function.Purpose:This study aimed to investigate whether peripheral microvascular function improved 2 hours after pitavastatin in subjects with coronary artery disease (CAD) using RH-PAT, and the results were compared with those of rosuvastatin.Methods:This study included 94 subjects with CAD, assigned to a group given 2 mg of pitavastatin (n = 36), a group given 2.5 mg of rosuvastatin (n = 38), and a control group (n = 20). RH-PAT examinations were performed before and 2 hours after statin administration.Results:The RH-PAT index increased 2 hours after pitavastatin administration from 1.82 ± 0.45 to 2.16 ± 0.62 (P = 0.02), whereas there were no differences in the RH-PAT index in the rosuvastatin group (1.79 ± 0.71 to 1.91 ± 0.53, P = 0.09) and the control group (1.68 ± 0.36 to 1.84 ± 0.58, P = 0.4). No significant changes were observed at 2 hours in serum cholesterol levels in each group.Conclusion:The present study demonstrated that peripheral microvascular function improved 2 hours after a single clinical dose of pitavastatin, but not after rosuvastatin.

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Section: Discussionmentioning

confidence: 83%