2017
DOI: 10.1016/s0168-8278(17)31451-4
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Short-term effect of DAA IFN-free regimens on liver stiffness

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Cited by 3 publications
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“…For these reasons, current data on cirrhosis reversibility after DAA therapy are of limited value, since they are based mostly on indirect indicators of liver fibrosis, such as LS measurements. For example, in a study by Pineda et al ., among 49 patients with pre-therapeutic LS values indicating cirrhosis (> 12.5 kPa), LS decreased to values that would indicate cirrhosis reversal (< 12.5 kPa) in 12 (24%) patients after reaching an SVR12 following DAA therapy [ 19 ]. In another study in which 392 patients with chronic hepatitis C were treated with DAA, regression of LS was noted, from an average of 12.65 kPa prior to therapy to 8.55 kPa 40 weeks after achieving an SVR, which is a reduction of 32% ( p < 0.001); meanwhile, the FIB4 score regressed from 2.5 to 1.8 [ 20 ].…”
Section: Cirrhosis Reversibility By Direct-acting Antiviralsmentioning
confidence: 99%
“…For these reasons, current data on cirrhosis reversibility after DAA therapy are of limited value, since they are based mostly on indirect indicators of liver fibrosis, such as LS measurements. For example, in a study by Pineda et al ., among 49 patients with pre-therapeutic LS values indicating cirrhosis (> 12.5 kPa), LS decreased to values that would indicate cirrhosis reversal (< 12.5 kPa) in 12 (24%) patients after reaching an SVR12 following DAA therapy [ 19 ]. In another study in which 392 patients with chronic hepatitis C were treated with DAA, regression of LS was noted, from an average of 12.65 kPa prior to therapy to 8.55 kPa 40 weeks after achieving an SVR, which is a reduction of 32% ( p < 0.001); meanwhile, the FIB4 score regressed from 2.5 to 1.8 [ 20 ].…”
Section: Cirrhosis Reversibility By Direct-acting Antiviralsmentioning
confidence: 99%