Short-term effect of an aqueous Fraxinus excelsior L. seed extract in spontaneously hypertensive rats

López-Carreras, Noemi; Fernández-Vallinas, Sandra; Hernández, Rosario; Miguel, Marta; Aleixandre, Amaya

doi:10.1016/j.foodres.2013.03.050

Cited by 12 publications

(18 citation statements)

References 34 publications

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“…In particular, the highest dose of SCFP (800 mg/kg/day) caused minimal effect in these animals than the 400 mg/kg/day dose. This paradox of a no dose-dependent antihypertensive effect had been observed earlier by our research group with different polyphenols and polyphenol-rich products, which we have evaluated also in SHR ( 26 , 27 ). Polyphenolic compounds act as natural antioxidants and have interesting benefits to health, but high doses of polyphenols might not always be needed to manifest beneficial biological activities ( 28 ).…”

Section: Discussionsupporting

confidence: 60%

Long-term antihypertensive effect of a soluble cocoa fiber product in spontaneously hypertensive rats

Fernández-Vallinas

Miguel

Aleixandre

2016

Food & Nutrition Research

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Background and MethodsThis study evaluates the antihypertensive effect of long-term intake of a soluble cocoa fiber product (SCFP). Different doses of SCFP were evaluated (200, 400, and 800 mg/kg/day) and a dose of 800 mg/kg/day of beta-glucan 0.75 (BETA-G) was used as a standard fiber. Water, a neutral vehicle, was used as negative control, and 50 mg/kg/day captopril was used as positive control. Systolic blood pressure (SBP) was measured weekly by the tail cuff method. Body weight, food, and liquid intake were also registered weekly in the rats from 10 to 24 weeks of life. Glucose, total cholesterol, and triglyceride levels; redox status; and the angiotensin-converting enzyme activity were also studied in the plasma samples of these animals.ResultsThroughout the 10 weeks of treatment, captopril and SCFP (400 mg/kg/day) demonstrated blood pressure lowering effects in the spontaneously hypertensive rats (p<0.05; n=8). Paradoxically, neither the highest dose (800 mg/kg/day) of SCFP decreased SBP nor 800 mg/kg/day BETA-G (p>0.05; n=8). When the corresponding antihypertensive treatment, was disrupted the SBP values of the 400 mg/kg/day SCFP treated animals returned to control values (p>0.05; n=8). In addition, the SCFP significantly decreased (p<0.05; n=4) the glucose, cholesterol, and triglyceride levels and also the liver and plasma malondaldehyde levels. Moreover, the SCFP slightly increased the reduced glutathione levels in the liver.ConclusionThe SCFP could be used to control the blood pressure of hypertensive subjects for a long period of time and could improve metabolic complications associated to cardiovascular diseases.

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Section: Discussionsupporting

confidence: 60%

Long-term antihypertensive effect of a soluble cocoa fiber product in spontaneously hypertensive rats

Fernández-Vallinas

Miguel

Aleixandre

2016

Food & Nutrition Research

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“…We used spontaneously hypertensive rats, a well-known animal model of hypertension. These rats are considered suitable for studying the antihypertensive properties of drugs or dietary supplements as the development of hypertension is very similar to that in humans [24].…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that tomato Gs supplement can be used as continuous preventive treatment to prevent an increase in blood pressure. If the supplement is suspended, it is plausible that blood pressure slowly recover, as happens after suspending Fraxinus excelsior L. seed extract treatments [24].…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum of Lycopersicum esculentum L. var. “Camone” Tomato in Spontaneously Hypertensive Rats

et al. 2020

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Blood pressure control in hypertensive subjects calls for changes in lifestyle, especially diet. Tomato is widely consumed and rich in healthy components (i.e., carotenoids, vitamins and polyphenols). The aim of this study was to evaluate the chemical composition and antihypertensive effects of locular gel reconstituted in serum of green tomatoes of “Camone” variety. Tomato serum and locular gel were chemically characterised. The antihypertensive effects of the locular gel in serum, pure tomatine, and captopril, administered by oral gavage, were investigated for 4 weeks in male spontaneously hypertensive and normotensive rats. Systolic blood pressure and heart rate were monitored using the tail cuff method. Body and heart weight, serum glucose, triglycerides and inflammatory cytokines, aorta thickness and liver metabolising activity were also assessed. Locular gel and serum showed good tomatine and polyphenols content. Significant reductions in blood pressure and heart rate, as well as in inflammatory blood cytokines and aorta thickness, were observed in spontaneously hypertensive rats treated both with locular gel in serum and captopril. No significant effects were observed in normotensive rats. Green tomatoes locular gel and serum, usually discarded during tomato industrial processing, are rich in bioactive compounds (i.e., chlorogenic acid, caffeic acid and rutin, as well as the glycoalkaloids, α-tomatine and dehydrotomatine) that can lower in vivo blood pressure towards healthier values, as observed in spontaneously hypertensive rats.

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“…TRP was determined using a previously published method [ 23 ]. Briefly, 500 μ L of each sample was treated with 2.5 mL of sodium phosphate buffer (0.2 mol/L, pH 6.6) and 2.5 mL of 1% potassium ferricyanide, and the resulting mixture was incubated at 50°C for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Tyrosinase Inhibitory Activities of Seed Oils from Torreya grandis Fort. ex Lindl.

Cui

Duan

Jia

et al. 2018

BioMed Research International

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Torreya grandis Fort. ex Lindl. is a plant belonging to the Taxaceae family and Torreya grandis cv. Merrillii is the only grafted and thoroughbred species belonging to this species. In this study, we extracted five different seed oils, including T. grandis seed oil (TGSO), T. grandis “Xiangyafei” seed oil (XYSO), T. grandis “Zhimafei” seed oil (ZMSO), T. grandis “Majus”seed oil (TGMSO), and T. grandis “cunguangfei” seed oil (CGSO) using physical pressure. The resulting extracts were analyzed to determine their fatty acid composition, antioxidant activity, and inhibitory activity towards tyrosinase. The results of the antioxidant activity assays revealed that XYSO and ZMSO exhibited much greater DPPH radical scavenging activity and ferric reducing power than TGSO. Notably, all five of the seed oils showed dose-dependent inhibitory activity towards tyrosinase. XYSO and TGSO gave the highest activities of all of the seed oils tested in the current study against monophenolase and diphenolase, with IC50 values of 227.0 and 817.5μg/mL, respectively. The results of this study show that wild TGSOs exhibit strong antioxidant and tyrosinase inhibition activities. These results therefore suggest that wild TGSOs could be used as a potential source of natural antioxidant agents and tyrosinase inhibitors.

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Short-term effect of an aqueous Fraxinus excelsior L. seed extract in spontaneously hypertensive rats

Cited by 12 publications

References 34 publications

Long-term antihypertensive effect of a soluble cocoa fiber product in spontaneously hypertensive rats

Long-term antihypertensive effect of a soluble cocoa fiber product in spontaneously hypertensive rats

Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum of Lycopersicum esculentum L. var. “Camone” Tomato in Spontaneously Hypertensive Rats

Antioxidant and Tyrosinase Inhibitory Activities of Seed Oils from Torreya grandis Fort. ex Lindl.

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