Short-Term Dynamic Observation of the Color Change and Enhancement Effect of Polyethylenimine-Entrapped Gold Nanoparticles Used for Indirect Lymphography

Yang, Yue; Shi, Fang; Zhou, Ji; Shi, Xiangyang; Sha, Yan; Wu, Haitao

doi:10.1159/000446190

Cited by 6 publications

(9 citation statements)

References 27 publications

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“…For reviewing the application of CT lymphography in early-stage OSCC, the systematic literature search led to retrieval of 112 PubMed indexed articles for CT lymphography, of which 17 were considered relevant [ 26 , 27 , 28 , 29 , 30 , 31 , 40 , 41 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. Of these 17 articles, 11 were animal studies [ 40 , 41 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. Cross-reference did not lead to any additional relevant articles.…”

Section: Resultsmentioning

confidence: 99%

“…For reviewing the application of CT lymphography in early-stage OSCC, the systematic literature search led to retrieval of 112 PubMed indexed articles for CT lymphography, of which 17 were considered relevant [26][27][28][29][30][31]40,41,[64][65][66][67][68][69][70][71][72]. Of these 17 articles, 11 were animal studies [40,41,[64][65][66][67][68][69][70][71][72].…”

Section: Ct Lymphographymentioning

confidence: 99%

“…Consequently, PET could be highly suitable for lymphoscintigraphy and may identify SLNs with higher precision than conventional lymphoscintigraphy with SPECT. Instead of a γ-emitter (e.g., [ 99m Tc], [ 60 Co])-labelled radiotracer, generally used for conventional lymphoscintigraphy, PET lymphoscintigraphy requires a positron emitting isotope (e.g., [ 89 Zr], [ 68 Ga], [ 18 F])-labelled radiotracer [74].…”

Section: Pet Lymphoscintigraphymentioning

confidence: 99%

“…Whereas labelling of nanocolloids with [ 68 Ga] is complicated, mainly due to instability of the bond between [ 68 Ga] and nanocolloids [106], [ 68 Ga] has been successfully labelled to tilmanocept [107]. Moreover, fluorescent (IRD-800CW)-labelled tilmanocept can be radiolabelled with both [ 68 Ga] and [ 99m Tc].…”

Section: Pet Lymphoscintigraphymentioning

confidence: 99%

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New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma

Mahieu

Maar

Nieuwenhuis

et al. 2020

Cancers

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Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure that aims to identify the first draining lymph node(s) from the primary tumor, the sentinel lymph nodes (SLN), as their histopathological status reflects the histopathological status of the rest of the nodal basin. The routine SLNB procedure consists of peritumoral injections with a technetium-99m [99mTc]-labelled radiotracer followed by lymphoscintigraphy and SPECT-CT imaging. Based on these imaging results, the identified SLNs are marked for surgical extirpation and are subjected to histopathological assessment. The routine SLNB procedure has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). However, an infamous limitation arises in situations where SLNs are located in close vicinity of the tracer injection site. In these cases, the hotspot of the injection site can hide adjacent SLNs and hamper the discrimination between tracer injection site and SLNs (shine-through phenomenon). Therefore, technical developments are needed to bring the diagnostic accuracy of SLNB for early-stage OSCC to a higher level. This review evaluates novel SLNB imaging techniques for early-stage OSCC: MR lymphography, CT lymphography, PET lymphoscintigraphy and contrast-enhanced lymphosonography. Furthermore, their reported diagnostic accuracy is described and their relative merits, disadvantages and potential applications are outlined.

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Section: Resultsmentioning

confidence: 99%

“…For reviewing the application of CT lymphography in early-stage OSCC, the systematic literature search led to retrieval of 112 PubMed indexed articles for CT lymphography, of which 17 were considered relevant [26][27][28][29][30][31]40,41,[64][65][66][67][68][69][70][71][72]. Of these 17 articles, 11 were animal studies [40,41,[64][65][66][67][68][69][70][71][72].…”

Section: Ct Lymphographymentioning

confidence: 99%

Section: Pet Lymphoscintigraphymentioning

confidence: 99%

Section: Pet Lymphoscintigraphymentioning

confidence: 99%

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New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma

Mahieu

Maar

Nieuwenhuis

et al. 2020

Cancers

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“…Therefore, Au NPs are potentially excellent CT contrast agents for indirect LG imaging to identify SLNs in the head and neck. There have been few studies of indirect LG using Au NPs as CT contrast [ 27 ] and it identified the enhanced SLNs 100% in all rabbits by indirect CT-LG. But it did not have controlled trials with Omnipaque and lymphatic tracer.…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model

Shi

Yang

Chen

et al. 2018

BioMed Research International

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Objective To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa. CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively. In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa. CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively. Then, SLN identification and enhancement characteristics were evaluated. Results Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN. SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye). At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively (P < 0.05). Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection (P < 0.05). The detection rate of SLN was 100%. Conclusions Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye. It is helpful for SLNs identification during the operation.

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Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta-analysis

Yang

Zhou

2017

Eur Arch Otorhinolaryngol

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The aim of this study was to systematically evaluate the diagnostic value of the sentinel lymph node biopsy (SLNB) for cT1/T2N0 tongue squamous cell carcinoma (TSCC) patients. A comprehensive and systematic literature review was performed by searching the Embase and PubMed databases for English language articles published up to December 2016. The pooled overall sentinel lymph node (SLN) detection rate, sensitivity and negative predictive value (NPV) were used to evaluate the diagnostic value of SLNB which used neck dissection or follow-up as a reference test. The Q test and I statistic were used to assess the heterogeneity across the studies. Subgroup analyses were performed in consideration of higher contribution of different clinical characteristics on the SLNB diagnostic value. Begg's linear regression and Egger's regression tests were conducted to evaluate the publication bias. Thirty-five studies (with 1084 patients) were included. The pooled SLN detection rate was 98% (95% CI 97-100%). The pooled overall sensitivity and NPV of SLNB were 0.92 (95% CI 0.88-0.95) and 0.96 (95% CI 0.94-0.97), respectively. The subgroup analyses demonstrated that higher extracted number of patients (n ≥ 30) from the included studies achieved a more stable NPV than lower number of patients. SLNB can effectively predict the status of regional lymph nodes in cT1/T2N0 TSCC patients. With high sensitivity and NPV, SLNB can guide the treatment of SLNB-positive patients with neck dissections and those with negative SLNBs with follow-ups in order to avoid unnecessary surgical morbidity.

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Short-Term Dynamic Observation of the Color Change and Enhancement Effect of Polyethylenimine-Entrapped Gold Nanoparticles Used for Indirect Lymphography

Cited by 6 publications

References 27 publications

New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma

New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma

Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model

Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta-analysis

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