Short-term dietary restriction in old mice rejuvenates the aging-induced structural imbalance of gut microbiota

Zeng, Ting; Cui, Hui; Tang, Duozhuang; Garside, George B.; Wang, Yiting; Wu, Jianying; Tao, Zhendong; Zhang, Liu; Si, Ting

doi:10.1007/s10522-019-09830-5

Cited by 30 publications

(16 citation statements)

References 47 publications

(65 reference statements)

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“…6f). The ratio between these species have been suggested to be altered in obesity [41][42][43] and aging 44 . Despite the changes in body composition, glycemic control, and exercise capacity observed in the current study, we did not see any effects of housing temperature or ET in the abundance of Bacteroidetes (Fig.…”

Section: Resultsmentioning

confidence: 99%

Housing temperature influences exercise training adaptations in mice

et al. 2020

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Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.

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Section: Resultsmentioning

confidence: 99%

Housing temperature influences exercise training adaptations in mice

et al. 2020

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“…Imbalance of the intestinal flora can lead to increased permeability of the intestinal wall and dysfunction of the intestinal mucosal barrier ( Zeng et al., 2019 ). In Figure 7 , lower expression of tight junction protein ZO-1 and occludin accompanied with the intestinal mucosal barrier disorder were observed in the aged group which might explain why their serum LPS concentrations were remarkably increased.…”

Section: Discussionmentioning

confidence: 99%

The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis

Sun

Zeng

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundAging induced chronic systemic inflammatory response is an important risk factor for atherosclerosis (AS) development; however, the detailed mechanism is yet to be elucidated.ObjectiveTo explore the underlying mechanism of how aging aggravates AS advancement.MethodsA young (five-week-old, YM) and aged group (32-week-old, OM) male apoE-/- mice with a high fat diet were used as models, and age-matched male wild-type C57BL/6J (WT) mice were used as controls. AS lesion size, serum lipid profile, cytokines, and gut microbiota-derived LPS were analyzed after 32 weeks of diet intervention. A correlation analysis between the 16S rRNA sequencing of the feces and serum metabolomics profiles was applied to examine the effect of their interactions on AS.ResultsApoE-/- mice developed severe atherosclerosis and inflammation in the aorta compared to the WT groups, and aged apoE-/- mice suffered from a more severe AS lesion than their younger counterparts and had low-grade systemic inflammation. Furthermore, increased levels of serum LPS, decreased levels of SCFAs production, as well as dysfunction of the ileal mucosal barrier were detected in aged mice compared with their younger counterparts. There were significant differences in the intestinal flora composition among the four groups, and harmful bacteria such as Lachnospiraceae_FCS020, Ruminococcaceae_UCG-009, Acetatifactor, Lachnoclostridium and Lactobacillus_gasseri were significantly increased in the aged apoE-/- mice compared with the other groups. Concurrently, metabolomics profiling revealed that components involved in the arachidonic acid (AA) metabolic pathway such as 20-HETE, PGF2α, arachidonic acid, and LTB4 were significantly higher in the aged AS group than in the other groups. This suggested that metabolic abnormalities and disorders of intestinal flora occurred in AS mice.ConclusionsAging not only altered the gut microbiome community but also substantially disturbed metabolic conditions. Our results confirm that AA metabolism is associated with the imbalance of the intestinal flora in the AS lesions of aged mice. These findings may offer new insights regarding the role of gut flora disorders and its consequent metabolite changed in inflammaging during AS development.

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“…[17][18][19][20][21][22], Erysipelotrichaceae [16,94], and Ruminococcaceae [94] in CR rodents compared with normal-diet rodents. Conversely, a decrease of Lactococcus spp., [22], Lachnospiraceae [22,95] and Clostridiales [94,95] was found in CR rodents compared with controls.…”

Section: Caloric Restriction (Cr) and Gut Microbiota Variationsmentioning

confidence: 87%

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Rinninella

Cintoni²,

Raoul

et al. 2020

Microorganisms

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In recent decades, there has been a growing interest in dietary restrictions for their promising effects on longevity and health span. Indeed, these strategies are supposed to delay the onset and burden of non-communicable diseases (NCDs) such as obesity, diabetes, cancer and neurological and gastrointestinal inflammatory diseases. At the same time, the gut microbiota has been shown to play a crucial role in NCDs since it is actively involved in maintaining gut homeostasis through its impact on nutrients metabolism, gut barrier, and immune system. There is evidence that dietary restrictions could slow down age-related changes in the types and numbers of gut bacteria, which may counteract gut dysbiosis. The beneficial effects on gut microbiota may positively influence host metabolism, gut barrier permeability, and brain functions, and subsequently, postpone the onset of NCDs prolonging the health span. These new insights could lead to the development of novel strategies for modulating gut microbiota with the end goal of treating/preventing NCDs. This review provides an overview of animal and human studies focusing on gut microbiota variations during different types of dietary restriction, in order to highlight the close relationship between gut microbiota balance and the host’s health benefits induced by these nutritional regimens.

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Short-term dietary restriction in old mice rejuvenates the aging-induced structural imbalance of gut microbiota

Cited by 30 publications

References 47 publications

Housing temperature influences exercise training adaptations in mice

Housing temperature influences exercise training adaptations in mice

The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

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