Short term dietary propylene glycol supplementation affects circulating metabolic hormones, progesterone concentrations and follicular growth in dairy heifers

Gamarra, G.; Ponsart, Claire; Lacaze, S.; Guienne, Brigitte Le; Deloche, Marie-Christine; Monniaux, Danielle; Ponter, Andrew

doi:10.1016/j.livsci.2014.01.015

Cited by 9 publications

(6 citation statements)

References 41 publications

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“…Gamarra et al (2014) mentioned that PG supplementation to dairy cows may be effective in improving oocyte production when combined with hormonal treatments to stimulate follicular growth for superovulation or ovum pick up. Plasma concentrations of glucose and insulin are known to increase in response to dietary PG (Miyoshi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Preliminary study of factors affecting the superovulatory response of high producing dairy cows superstimulated regardless of the stage of estrous cycle in Egypt

Hussein

Aziz

Abdel‐Wahab

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

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ParityPropylene glycol a b s t r a c t This work was conducted as a first time commercial production of embryos from lactating Holstein and Brown Swiss cows using multiple ovulation embryo transfer (MOET) technology in Egypt. We studied factors affecting the superovulatory response (SR) in superovulated cows and effects of propylene glycol (PG) on embryo quality. Daily milk production at flushing had significantly negative effects on SR and embryo yields in superovulated cows. In addition, Brown Swiss cows had better SR than Holstein cows.Moreover, cows having more than 3 parities yielded better response, compared to cows in the first three parities. However, factors such as body weight at flushing, body condition score (BCS) at flushing and days in milk (DIM) at flushing did not have any association with SR in cows. In addition, drenching of PG prior to and during the superovulatory treatment improved SR (Right CL number, P < 0.05; Left CL number, P < 0.05), total embryos per flush (P < 0.05), first grade embryos per flush (P < 0.01) and tended to improve transferable embryos (P ¼ 0.13) and second grade embryos per flush (P ¼ 0.11). However, it tended to increase the number of degenerated embryos per flush (0.06). In conclusion, commercial production of embryos from lactating Holstein and Brown Swiss cows regardless of stage of estrous cycle by MOET proved successful under Egyptian conditions. Milk yield was negatively associated with SR and embryo yields in superovulated cows. Moreover, drenching of PG prior to and during the superovulatory treatment improved SR and embryo yields.

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Section: Discussionmentioning

confidence: 99%

Preliminary study of factors affecting the superovulatory response of high producing dairy cows superstimulated regardless of the stage of estrous cycle in Egypt

Hussein

Aziz

Abdel‐Wahab

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

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“…They also found that when insulin was injected before mating, a strong relationship between ovulations and number of transferable embryos was found. However, it has been shown that feeding regimens which increase insulin (hyperinsulinemia) stimulate follicular growth and increase follicular recruitment in heifers [19] and mares [20]. The increase in insulin and IGF-1 levels had a stimulatory effect on follicular growth (small follicle) before superovulation [21].…”

Section: Discussionmentioning

confidence: 99%

Effect of insulin or insulin-like growth factor-I administration at mid-luteal phase of the estrous cycle during superovulation on hormonal profile of Sahiwal cows

2018

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Aim:The present study was designed to study the effect of insulin and insulin-like growth factor-1 (IGF-I) administration during luteal phase of the estrous cycle on the hormonal profile of Sahiwal embryo donor cows during superovulation.Materials and Methods:Cows (n=18) were selected and divided into three groups; control (n=6, untreated), T-I (n=6, insulin-treated), and T-II (n=6, IGF-I treated). Insulin and IGF-I were given S/C on 5th, 6th, 7th, and 8th days of estrous cycle. Superovulatory treatment was started on day 9th of the estrous cycle. With the sixth dose of follicle-stimulating hormone, prostaglandin was injected to induce superovulatory heat. The superovulated cows were bred, and superovulatory response of each animal was recorded. The embryos were collected non-surgically on the 7th day of superovulatory estrus. About 15 ml blood without anticoagulant was collected on days 5, 7, 9, 11, 13, 15, 17, 19, and 21 or day of embryo recovery where day 0 of estrous cycle was taken as day of estrus. Serum was separated, centrifuged, and transferred into sterilized serum vials. All samples were stored at −20°C till analysis. Progesterone, insulin, and IGF-I were estimated in blood serum by radioimmunoassay using radioimmunoassay kits.Results and Discussion:The mean concentration of progesterone on days 7 and 11, insulin on days 7 and 9, and IGF-I on days 5, 7, 9, 11, and 15 was significantly higher in insulin-treated T-I groups as compared to untreated control.Conclusion:It may be concluded that exogenous insulin administration during mid-luteal phase may be helpful in follicular and embryonic development through modulation of progesterone, insulin, and IGF-I in indigenous (Bos indicus) Sahiwal embryo donor cows.

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“…The results of Gamarra et al [56] indicated that short-term dietary PG supplementation affected circulating concentrations of metabolites and metabolic hormones, increased progesterone concentrations, and the number of small follicles. The embryo losses were related to the reduced progesterone and the increase in progesterone stimulates and sustains endometrial functions essential for embryonic survival, implantation, and growth [72].…”

Section: The Effects Of Pg On Reproductive Performancementioning

confidence: 99%

“…In addition, insulin resistance is an adaptation to the very high glucose requirements for lactation, thereby conserving glucose for lactation by limiting its use by insulin-sensitive tissues (muscle, adipose tissue etc.) [56]. The insulin resistance can hence be attributed to a decrease in insulin responsiveness and a decrease in insulin sensitivity [57].…”

Section: The Anti-ketogenic Properties Of Pg and The Mechanism Of Inhmentioning

confidence: 99%

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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With the improvement in the intense genetic selection of dairy cows, advanced management strategies, and improved feed quality and disease control, milk production level has been greatly improved. However, the negative energy balance (NEB) is increasingly serious at the postpartum stage because the intake of nutrients cannot meet the demand of quickly improved milk production. The NEB leads to a large amount of body fat mobilization and consequently the elevated production of ketones, which causes metabolic diseases such as ketosis and fatty liver. The high milk production of dairy cows in early lactation aggravates NEB. The metabolic diseases lead to metabolic disorders, a decrease in reproductive performance, and lactation performance decline, seriously affecting the health and production of cows. Propylene glycol (PG) can alleviate NEB through gluconeogenesis and inhibit the synthesis of ketone bodies. In addition, PG improves milk yield, reproduction, and immune performance by improving plasma glucose and liver function in ketosis cows, and reduces milk fat percentage. However, a large dose of PG (above 500 g/d) has toxic and side effects in cows. The feeding method used was an oral drench. The combination of PG with some other additives can improve the effects in preventing ketosis. Overall, the present review summarizes the recent research progress in the impacts of NEB in dairy cows and the properties of PG in alleviating NEB and reducing the risk of ketosis.

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Short term dietary propylene glycol supplementation affects circulating metabolic hormones, progesterone concentrations and follicular growth in dairy heifers

Cited by 9 publications

References 41 publications

Preliminary study of factors affecting the superovulatory response of high producing dairy cows superstimulated regardless of the stage of estrous cycle in Egypt

Preliminary study of factors affecting the superovulatory response of high producing dairy cows superstimulated regardless of the stage of estrous cycle in Egypt

Effect of insulin or insulin-like growth factor-I administration at mid-luteal phase of the estrous cycle during superovulation on hormonal profile of Sahiwal cows

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

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