Short-term Dietary Interventions for the Management of Nonalcoholic Fatty Liver

Stokes, Caroline S.; Lammert, Frank; Krawczyk, Marcin

doi:10.2174/0929867324666170508144409

Cited by 3 publications

(3 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, overconsumption of simple sugars increased the intrahepatic TG content (+ 33%) by stimulating DNL (+ 98%). In a review by Stokes et al [ 84 ], short-term hypocaloric diets (up to 16 wk) have shown beneficial effects in reducing intrahepatic lipid content. Also, research supports that carbohydrate restriction and consumption of unsaturated fatty acids have efficacious metabolic effects in NAFLD[ 12 , 81 , 84 ].…”

Section: Dietary Intervention Studies In Nafld Patientsmentioning

confidence: 99%

“…In a review by Stokes et al [ 84 ], short-term hypocaloric diets (up to 16 wk) have shown beneficial effects in reducing intrahepatic lipid content. Also, research supports that carbohydrate restriction and consumption of unsaturated fatty acids have efficacious metabolic effects in NAFLD[ 12 , 81 , 84 ]. Obesity is closely related to low levels of n-3 PUFA in plasma phospholipids[ 85 ].…”

Section: Dietary Intervention Studies In Nafld Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

Ristić‐Medić¹,

Bajerska²,

Vučić³

2022

WJG

View full text Add to dashboard Cite

The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions’ impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.

show abstract

Section: Dietary Intervention Studies In Nafld Patientsmentioning

confidence: 99%

Section: Dietary Intervention Studies In Nafld Patientsmentioning

confidence: 99%

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

Ristić‐Medić¹,

Bajerska²,

Vučić³

2022

WJG

View full text Add to dashboard Cite

show abstract

“…onalcoholic fatty liver disease (NAFLD), one of the most prevalent liver diseases worldwide, is closely associated with metabolic diseases, such as obesity, dyslipidemia and type 2 diabetes (T2D) (1,2). It is well recognized that chronic intake of Western-style diet rich in fat and sugar is a major factor responsible for the development of NAFLD (1)(2)(3). However, the mechanisms contributing to the development and progression of NAFLD under high-fat (Western) diet condition have never been fully clarified.…”

mentioning

confidence: 99%

Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice

Su¹,

Zhang²,

Chen³

et al. 2020

Food & Nutrition Research

View full text Add to dashboard Cite

Background: Recent evidence indicates that the inhibition of hepatocyte apoptosis is possible to develop a potential therapeutic strategy for nonalcoholic fatty liver disease (NAFLD). Our previous work suggested that purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, effectively improved many features of high-fat diet (HFD)-induced NAFLD. However, whether PSPC ameliorates HFD-induced hepatocyte apoptosis has never been investigated. Objective: Here we investigated the effects of PSPC on HFD-induced hepatic apoptosis and the mechanisms underlying these effects. Design: Mice were divided into four groups: Control group, HFD group, HFD + PSPC group and PSPC group. PSPC was administered by daily oral gavage at doses of 700 mg/kg/day for 20 weeks. EX-527 (a SirT1-selective inhibitor) and Sirt1 siRNA were used to demonstrate the Sirt1 dependence of PSPC-mediated effects on apoptotic and survival signaling pathways in vivo and in vitro. Results: Our results showed that PSPC reduced body weights, hepatic triglyceride contents, histopathological lesions and serum ALT levels in a mouse model of NAFLD induced by HFD. Furthermore, PSPC attenuated HFD-induced hepatocyte apoptosis ratio from 7.27 ± 0.92% to 1.79 ± 0.27% in mouse livers, which is insignificant compared with that of controls. Moreover, PSPC activated Sirt1 by boosting NAD + level in HFD-treated mouse livers. Furthermore, PSPC promoted Sirt1-dependent suppression of P53-mediated apoptotic signaling and activation of Akt survival signaling pathway in HFD-treated mouse livers, which was confirmed by EX527 treatment. Moreover, Sirt1 knockdown abolished these ameliorative effects of PSPC on apoptosis and P53 acetylation and protein expression in PA-treated L02 cells. Ultimately, PSPC reduced Caspase-3 activation and Bax level, and elevated the Bcl-2 level in HFD-treated mouse livers. Conclusion: PSPC protected against HFD-induced hepatic apoptosis by promoting Sirt1-dependent inhibition of p53-apoptotic pathway and facilitation of Akt survival pathway. This study indicates that PSPC is a candidate for nutritional intervention of NAFLD.

show abstract

Fructose and Non-Alcoholic Steatohepatitis

Roeb

Weiskirchen

2021

Front. Pharmacol.

View full text Add to dashboard Cite

Background: The excessive consumption of free sugars is mainly responsible for the high prevalence of obesity and metabolic syndrome in industrialized countries. More and more studies indicate that fructose is involved in the pathophysiology and also in the degree of disease of non-alcoholic fatty liver disease (NAFLD). In epidemiologic studies, energy-adjusted higher fructose consumption correlates with NAFLD in overweight adults. In addition to glucose, fructose, as an equivalent component of conventional household sugar, appears to have negative metabolic effects in particular due to its exclusive hepatic metabolism. Liver-related mortality is strictly associated with the degree of fibrosis, whereas the most common cause of death in patients suffering from NAFLD and non-alcoholic steatohepatitis (NASH) are still cardiovascular diseases. In this review article, we have summarized the current state of knowledge regarding a relationship between fructose consumption, liver fibrosis and life expectancy in NASH.Method: Selective literature search in PubMed using the keywords ‘non-alcoholic fatty liver’, ‘fructose’, and ‘fibrosis’ was conducted.Results: The rate of overweight and obesity is significantly higher in both, adult and pediatric NASH patients. The consumption of free sugars is currently three times the maximum recommended amount of 10% of the energy intake. The current literature shows weight gain, negative effects on fat and carbohydrate metabolism and NASH with hypercaloric intake of fructose.Conclusions: Excessive fructose consumption is associated with negative health consequences. Whether this is due to an excess of energy or the particular metabolism of fructose remains open with the current study situation. The urgently needed reduction in sugar consumption could be achieved through a combination of binding nutritional policy measures including taxation of sugary soft drinks. Previous studies suggest that diet-related fructose intake exceeding the amount contained in vegetables and fruits lead to an increase of hepatic lipogenesis. Thus, further studies to clarify the protective contribution of low-fructose intake to positively influence NAFLD in industrial population are urgently required.

show abstract

Short-term Dietary Interventions for the Management of Nonalcoholic Fatty Liver

Cited by 3 publications

References 73 publications

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice

Fructose and Non-Alcoholic Steatohepatitis

Contact Info

Product

Resources

About