Short-term Dehydroepiandrosterone Intake and Supramaximal Exercise in Young Recreationally-trained Women

Gravisse, Nicolas; Vibarel-Rebot, N.; Labsy, Z.; Do, Manh-Cuong; Gagey, Olivier; Dubourg, Céline; Audran, Michel; Collomp, K.

doi:10.1055/a-0631-3008

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…35,41 Forty-seven studies were finally included in the meta-analyses: 10 controlled studies and 49 pre-post intervention groups (i.e., 10 intervention groups from controlled studies plus 39 pre-post intervention groups). Six studies collected only one sample at 5 min, 42,54,77,78 10 min, 44 and 300 min 43 after HIIT. Because of the reduced number of studies with samples collected at these minutes, a meta-analysis was not able to be conducted.…”

Section: Search Resultsmentioning

confidence: 99%

“…The reasons for exclusion based on full‐text documents were: (i) other exercise interventions or sports (142 studies); (ii) HIIT and other exercise (13 studies); (iii) HIIT intervention (11 studies); (iv) duplicate participants (7 studies); (v) high‐intensity resistance training (6 studies); (vi) impossible to contact authors and extract data (1 article); (vii) full text not available (1 article); (viii) obese (1 article). Finally, 53 studies meeting our inclusion criteria were included in this systematic review: 13 controlled studies 34‐46 and 55 pre‐post intervention groups (13 intervention groups from controlled studies +42 pre‐post intervention groups) 35,41,47‐86 . Two studies involved both controlled studies and pre‐post intervention groups 35,41 .…”

Section: Resultsmentioning

confidence: 99%

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Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta‐analysis

Dote-Montero

Carneiro‐Barrera

Vizcaíno

et al. 2021

Scandinavian Med Sci Sports

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To determine the acute effect of a single high‐intensity interval training (HIIT) session on testosterone and cortisol levels in healthy individuals, a systematic search of studies was conducted in MEDLINE and Web of Science databases from inception to February 2020. Meta‐analyses were performed to establish the acute effect of HIIT on testosterone and cortisol levels immediately after a single HIIT session; after 30 min and 60 min (primary outcomes); and after 120 min, 180 min, and 24 h (secondary outcomes, only for pre‐post intervention groups). Potential effect‐size modifiers were assessed by meta‐regression analyses and analyses of variance. Study quality was assessed using the Cochrane's risk of bias tool and the Physiotherapy Evidence Database scale. The meta‐analyses of 10 controlled studies (213 participants) and 50 pre‐post intervention groups (677 participants) revealed a significant increase in testosterone immediately after a single HIIT session (d = 0.92 and 0.52, respectively), which disappeared after 30 min (d = 0.18 and −0.04), and returned to baseline values after 60 min (d = −0.37 and −0.16). Significant increases of cortisol were found immediately after (d = 2.17 and 0.64), after 30 min (d = 1.62 and 0.67) and 60 min (d = 1.32 and 0.27). Testosterone and cortisol levels decreased significantly after 120 min (d = −0.48 and −0.95, respectively) and 180 min (d = −0.29 and −1.08), and returned to baseline values after 24 h (d = 0.14 and −0.02). HIIT components and participant's characteristics seem to moderate the effect sizes. In conclusion, testosterone and cortisol increase immediately after a single HIIT session, then drop below baseline levels, and finally return to baseline values after 24 h. This meta‐analysis provides a better understanding of the acute endocrine response to a single HIIT session, which would certainly be valuable for both clinicians and coaches in the prescription of exercise programs to improve health and performance. Testosterone and cortisol may be used as sensitive biomarkers to monitor the anabolic and catabolic response to HIIT.

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Section: Search Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta‐analysis

Dote-Montero

Carneiro‐Barrera

Vizcaíno

et al. 2021

Scandinavian Med Sci Sports

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“…There is a consensus that the use of classic AAS such as testosterone and nandrolone esters is associated with greater physiological adverse effects in females than male athletes, with hirsutism, voice deepening, and menstrual disturbances, though this depends on the molecule (Franke and Berendonk, 1997 ; Fitch, 2008 ; Huang and Basaria, 2018 ). Use of other AAS considered to be steroid precursors, such as DHEA, has been less documented in a young healthy population but seems to induce fewer ergogenic, physiological and psychological side effects in recreationally trained female athletes (Gravisse et al, 2018 ). However, the physiological side effects of other non-androgenic anabolic agents such as clenbuterol appear to be more limited than those of AAS in female athletes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Prohibited Substance Use and Methods by Female Athletes: Evidence of Gender-Related Differences

Collomp¹,

Ericsson²,

Bernier³

et al. 2022

Front. Sports Act. Living

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To achieve optimal sports performances, women and men may show specific doping practices because of the physiological and psychological gender differences, but there are few data on this topic. Here, we report the apparent use of prohibited substances and methods by female athletes based on analyses of the doping tests collected by the French Anti-Doping Agency from 2013 to 2019. We compared the frequency of use and the ergogenic and side effects to those of their male counterparts. The results revealed lower use of prohibited substances in female vs. male athletes, with significantly fewer anabolic agents, hormone and metabolic modulators, and cannabinoids. Gender specificity in utilization of substance classes was also shown. Relatively lower use of hormone modulators and cannabinoids and higher use of beta-2 agonists, diuretics and glucocorticoids were found in the woman cohort compared with men cohort, combined with the different choice of substances, possibly because of the altered ergogenic and/or side effects. However, no impact due to gender regarding the sports disciplines was observed, with both women and men showing similar use of anabolic agents, mainly in the anaerobic sports, and EPO and corticoids, mainly in endurance or mixed sports. Further studies are needed to put these French data into a global perspective, comparing uses across countries and exploring possible new developments in the fight against doping in women.

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“…3 The subjects had been training an average of 60-90 minutes, 3 to 5 times per week, for at least 3 years.…”

Section: Experimental Designmentioning

confidence: 99%

“…The cohort of subjects was the same as that of a series of studies investigating the effects of DHEA on young healthy volunteers. 3,30 This doubleblind, placebo-controlled, randomized crossover study consisted of two, 4-week periods of treatment for each subject: placebo (Pla) and DHEA, separated by a wash-out period of 4 weeks. For each treatment, the subjects took one capsule of either Pla (lactose) or DHEA (100 mg) at home every morning between 06:30 and 07:00 for 28 days.…”

Section: Experimental Designmentioning

confidence: 99%

Metabolic and isotopic signature of short‐term DHEA administration in women: Comparison with findings in men

Buisson

Frelat

Privat

et al. 2018

Drug Testing and Analysis

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The impact of dehydroepiandrosterone (DHEA) administration has been widely studied for anti-doping purposes in men, whereas only a few studies have been performed in women. In the present study, the impact of DHEA on the steroid profile parameters and their carbon isotopic ratios was explored. Eleven healthy young women and 10 healthy young men received two treatments: One with 100 mg/day of DHEA for 28 days and one with a placebo according to a double-blind crossover protocol. Urine and saliva (only in females) samples were collected before and for 72 hours after each short-term treatment. In all female subjects, concentrations of the urinary parameters of the steroid profile were highly impacted by short-term DHEA administration including epitestosterone (E). Gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) analysis was performed and positive results were observed for E in the four female subjects where E concentration was adequate for such analysis, whereas men results remained negative for E. Last, the ability of the Anti-Doping Administration and Management System (ADAMS) software used for the athlete biological passport to identify such doping was assessed. Of the 11 passports generated for female subjects, 10 were automatically classified as an atypical passport finding (ATPF). For the remaining passport with normal status in one woman, the variability of the concentrations prevented the ADAMS software from adjusting individual limits. The most impacted markers in women were T/E and 5αAdiol/E, with a detection window of 36 hours for 5αAdiol/E. In addition, good correlations were observed for DHEA and T concentrations in urine and saliva in females.

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Short-term Dehydroepiandrosterone Intake and Supramaximal Exercise in Young Recreationally-trained Women

Cited by 8 publications

References 42 publications

Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta‐analysis

Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta‐analysis

Prevalence of Prohibited Substance Use and Methods by Female Athletes: Evidence of Gender-Related Differences

Metabolic and isotopic signature of short‐term DHEA administration in women: Comparison with findings in men

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