Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson’s disease

Naranjo, Claudia Carricarte; Marras, Connie; Visanji, Naomi P.; Cornforth, David; Sanchez-Rodriguez, Lazaro M.; Schüle, Birgitt; Goldman, Samuel; Estévez, Mario; Stein, Phyllis K.; Lang, Anthony E.; Jelinek, Herbert F.; Machado, Andrés

doi:10.1007/s10286-021-00815-4

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…Beyond HRV, which is a commonly used objective measure of autonomic nerve tension, DC of heart rate also offers a non-invasive and straightforward assessment. DC is derived from the periodic changes in RR intervals of sinus rhythm, where an increased DC value indicates enhanced vagal excitability and vice versa 29 , 30 . Zheng L 31 found that in patients without recurrence, DC values decreased rapidly one day post-ablation and remained below baseline levels throughout the first postoperative year, suggesting that CNA may prevent recurrence by reducing vagal nerve tension.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study

Han,

Shao,

Yang

et al. 2024

Sci Rep

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Cardioneuroablation (CNA) is currently considered as a promising treatment option for patients with symptomatic bradycardia caused by vagotonia. This study aims to further investigate its safety and efficacy in patients suffering from vagal bradycardia. A total of 60 patients with vagal bradycardia who underwent CNA in the First Affiliated Hospital of Xinjiang Medical University from November 2019 to June 2022. Preoperative atropine tests revealed abnormal vagal tone elevation in all patients. First, the electroanatomic structures of the left atrium was mapped out by using the Carto 3 system, according to the protocol of purely anatomy-guided and local fractionated intracardiac electrogram-guided CNA methods. The upper limit of ablation power of superior left ganglion (SLGP) and right anterior ganglion (RAGP) was not more than 45W with an ablation index of 450.Postoperative transesophageal cardiac electrophysiological examination was performed 1 to 3 months after surgery. The atropine test was conducted when appropriate. Twelve-lead electrocardiogram, Holter electrocardiogram, and skin sympathetic nerve activity were reviewed at 1, 3, 6 and 12 months after operation. Adverse events such as pacemaker implantation and other complications were also recorded to analyze the safety and efficacy of CNA in the treatment of vagus bradycardia. Sixty patients were enrolled in the study (38 males, mean age 36.67 ± 9.44, ranging from 18 to 50 years old). None of the patients had a vascular injury, thromboembolism, pericardial effusion, or other surgical complications. The mean heart rate, minimum heart rate, low frequency, low/high frequency, acceleration capacity of rate, and skin sympathetic nerve activity increased significantly after CNA. Conversely, SDNN, PNN50, rMSSD, high frequency, and deceleration capacity of rate values decreased after CNA (all P < 0.05). At 3 months after ablation, the average heart rate, maximum heart rate, and acceleration capacity of heart rate remained higher than those before ablation, and the deceleration capacity of heart rate remained lower than those before ablation and the above results continued to follow up for 12 months after ablation (all P < 0.05). There was no significant difference in other indicators compared with those before ablation (all P > 0.05). The remaining 81.67% (49/60) of the patients had good clinical results, with no episodes of arrhythmia during follow-up. CNA may be a safe and effective treatment for vagal-induced bradycardia, subject to confirmation by larger multicenter trials.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study

Han,

Shao,

Yang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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Potential for heart rate deceleration capacity in assessing perioperative autonomic function and predicting adverse cardiovascular events

Sun,

Xu,

et al. 2024

British Journal of Anaesthesia

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Cardiac deceleration capacity as an indicator for cardioneuroablation in patients with refractory vasovagal syncope

et al. 2022

Heart Rhythm

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Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson’s disease

Cited by 5 publications

References 56 publications

Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study

Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study

Potential for heart rate deceleration capacity in assessing perioperative autonomic function and predicting adverse cardiovascular events

Cardiac deceleration capacity as an indicator for cardioneuroablation in patients with refractory vasovagal syncope

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