Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans

Bavel

et al. 2014

Nutr J

BackgroundDietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals.MethodsThis open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS.ResultsCrS did not alter plasma levels of homocysteine, although CrS increased creatinine (p = 0.0001) and decreased uric acid (p = 0.0004) plasma levels. Significant changes in total cholesterol (p = 0.0486) and LDL-cholesterol (p = 0.0027) were also observed along with a reduction in plasma levels of T3 (p = 0.0074) and an increase in T4 levels (p = 0.0003). Skin functional capillary density (p = 0.0496) and capillary recruitment during post-occlusive reactive hyperemia (p = 0.0043) increased after CrS. Increases in cutaneous microvascular vasodilation induced by post-occlusive reactive hyperemia (p = 0.0078) were also observed.ConclusionsOral supplementation with creatine in healthy, moderately physically active young adults improves systemic endothelial-dependent microvascular reactivity and increases skin capillary density and recruitment. These effects are not concurrent with changes in plasma homocysteine levels.

Section: Introductionmentioning

confidence: 99%

Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Bavel

et al. 2014

Nutr J

“…Other factors that may influence these differences are linked to distinct study protocols along with different dosages, age, and gender of populations and especially to studies with reduced numbers of participants . Yet, some studies in humans suggest that oral CrS does not alter vascular reactivity but instead causes significant elevations of plasma homocysteine levels in normohomocysteinemic subjects, despite that it causes significant reductions in hyperhomocysteinemic individuals .…”

Section: Discussionmentioning

confidence: 99%

“…In this context, creatine supplementation has been suggested to be capable of reducing homocysteine blood levels, exerting positive influences on vascular endothelial function . In contradiction, some studies in humans suggest that creatine supplementation does not alter vascular reactivity but instead causes significant elevation of serum homocysteine in normohomocysteinemic subjects, despite that it causes significant reductions in hyperhomocysteinemic individuals .…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets

Bavel

Fundamemntal Clinical Pharma

Tibiriçá

2019

“…In physically active subjects, erythrocyte folate and serum vitamin B 12 were stable in both a normoxia- and hypoxia-training for 4 weeks [ 28 ]. In soccer players, plasma folate concentrations before and after acute high-intensity sprint exercise were similar, but vitamin B 12 concentration after exercise was significantly higher than that before exercise [ 29 ]. Individuals involved in high intensity physical activity for at least 5 years had slightly higher plasma vitamin B 12 concentrations than sedentary individuals [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of exercise training and acute exercise duration on plasma folate and vitamin B₁₂

2016

BACKGROUND/OBJECTIVESEnergy production and the rebuilding and repair of muscle tissue by physical activity require folate and vitamin B12 as a cofactor. Thus, this study investigated the effects of regular moderate exercise training and durations of acute aerobic exercise on plasma folate and vitamin B12 concentrations in moderate exercise trained rats.MATERIALS/METHODSFifty rats underwent non-exercise training (NT, n = 25) and regular exercise training (ET, n = 25) for 5 weeks. The ET group performed moderate exercise on a treadmill for 30 min/day, 5 days/week. At the end of week 5, each group was subdivided into 4 groups: non-exercise and 3 exercise groups. The non-exercise group (E0) was sacrificed without exercising and the 3 exercise groups were sacrificed immediately after exercising on a treadmill for 0.5 h (E0.5), 1 h (E1), and 2 h (E2). Blood samples were collected and plasma folate and vitamin B12 were analyzed.RESULTSAfter exercise training, plasma folate level was significantly lower and vitamin B12 concentration was significantly higher in the ET group compared with the NT group (P < 0.05). No significant associations were observed between plasma folate and vitamin B12 concentrations. In both the NT and ET groups, plasma folate and vitamin B12 were not significantly changed by increasing duration of aerobic exercise. Plasma folate concentration of E0.5 was significantly lower in the ET group compared with that in the NT group. Significantly higher vitamin B12 concentrations were observed in the E0 and E0.5 groups of the ET group compared to those of the NT group.CONCLUSIONRegular moderate exercise training decreased plasma folate and increased plasma vitamin B12 levels. However, no significant changes in plasma folate and vitamin B12 concentrations were observed by increasing duration of acute aerobic exercise.